Skip to main content
×
Home
    • Aa
    • Aa

Glycaemic index, glycaemic load and ovarian cancer risk: a prospective cohort study

  • Stephanie AN Silvera (a1), Meera Jain (a2), Geoffrey R Howe (a3), Anthony B Miller (a2) and Thomas E Rohan (a4)...
Abstract
AbstractBackground

There is some evidence that plasma insulin levels might influence ovarian cancer risk. Glyacemic index (GI) and glycaemic load (GL) are measures that allow the carbohydrate content of individual foods to be classified according to their postprandial glycaemic effects and hence their effects on circulating insulin levels. Therefore, we examined ovarian cancer risk in association with GI and GL, and intake of dietary carbohydrate and sugar.

Methods

The study was conducted in a prospective cohort of 49 613 Canadian women enrolled in the National Breast Screening Study (NBSS) who completed a self-administered food-frequency questionnaire (FFQ) between 1980 and 1985. Linkages to national mortality and cancer databases yielded data on deaths and cancer incidence, with follow-up ending between 1998 and 2000. Data from the FFQ were used to estimate overall GI and GL, and Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between energy-adjusted quartile levels of GL, overall GI, total carbohydrates, total sugar and ovarian cancer risk.

Results

During a mean 16.4 years of follow-up, we observed 264 incident ovarian cancer cases. GI and total carbohydrate and sugar intakes were not associated with ovarian cancer risk in the total cohort. GL was positively associated with a 72% increase in risk of ovarian cancer (HR = 1.72, 95% CI = 1.13–2.62, Ptrend = 0.01) and the magnitude of the association was slightly greater among postmenopausal (HR = 1.89, 95% CI = 0.98–3.65, Ptrend = 0.03) than among premenopausal women (HR = 1.64, 95% CI = 0.95–2.88, Ptrend = 0.07).

Conclusions

Our data suggest that consumption of diets with high GL values may be associated with increased risk of ovarian cancer.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Glycaemic index, glycaemic load and ovarian cancer risk: a prospective cohort study
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Glycaemic index, glycaemic load and ovarian cancer risk: a prospective cohort study
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Glycaemic index, glycaemic load and ovarian cancer risk: a prospective cohort study
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Email silveras@mail.montclair.edu
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1HA Risch . Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. Journal of the National Cancer Institute 1998; 90: 1774–86.

4L Poretsky , MF Kalin . The gonadotropic function of insulin. Endocrine Reviews 1987; 8: 132–41.

5JE Nestler , DJ Jakubowicz . Decreases in ovarian cytochrome P450c17-alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome. New England Journal of Medicine 1996; 335: 617–23.

6A Lukanova , E Lundin , A Micheli , A Akhmedkhanov , S Rinaldi , P Muti , . Risk of ovarian cancer in relation to prediagnostic levels of C-peptide, insulin-like growth factor binding proteins-1 and -2 (USA, Sweden, Italy). Cancer Causes & Control 2003; 14: 285–92.

7L Dal Maso , LS Augustin , S Franceschi , R Talamini , J Polesel , CW Kendal , . Association between components of the insulin-like growth factor system and epithelial ovarian cancer risk. Oncology 2004; 67: 225–30.

8A Flyvbjerg , O Mogensen , B Mogensen , OS Nielsen . Elevated serum insulin-like growth factor-binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: correlation with cancer antigen 125 and tumor-associated trypsin inhibitor. Journal of Clinical Endocrinology 1997; 82: 2308–13.

9A Lukanova , E Lundin , P Toniolo , A Micheli , A Akhmedkhanov , S Rinaldi , . Circulating levels of insulin-like growth factor-1 and risk of ovarian cancer. International Journal of Cancer 2002; 101: 549–54.

10EJ Lee , C Mircean , I Shmulevich , H Wang , J Liu , A Niemisto , . Insulin-like growth factor binding protein 2 promotes ovarian cancer cell invasion. Molecular Cancer 2005; 4: 7.

12C Ionescu-Tirgoviste , E Popa , E Sintu , N Mihalache , D Cheta , I Mincu . Blood glucose and plasma insulin responses to various carbohydrates in type 2 (non-insulin-dependent diabetes). Diabetologia 1983; 24: 80–4.

17LS Augustin , J Polesel , C Bosetti , CWC Kendall , C La Vecchia , M Parpinel , . Dietary glycemic index, glycemic load and ovarian cancer risk: a case–control study in Italy. Annals of Oncology 2003; 14: 78–84.

18D Trout , KM Behall . Prediction of glycemic index among high-sugar, low-starch foods. International Journal of Food Sciences and Nutrition 1999; 50: 135–44.

20PD Terry , AB Miller , JG Jones , TE Rohan . Cigarette smoking and the risk of invasive epithelial ovarian cancer in a prospective cohort study. European Journal of Cancer 2003; 39: 1157–64.

23TE Rohan , W Hartwick , AB Miller , RA Kandel . Immunohistochemical detection of c-erbB-2 and p-53 in benign breast disease and breast cancer risk. Journal of the National Cancer Institute 1998; 90: 1262–9.

26M Lajous , W Willett , E Lazcano-Ponce , LM Sanchez-Zamorano , M Hernandez-Avila , I Romieu . Glycemic load, glycemic index, and the risk of breast cancer among Mexican women. Cancer Causes & Control 2005; 16: 1165–9.

28KJ Rothman , S Greenland . Modern Epidemiology. Philadelphia, PA: Lippincott-Raven, 1998.

30E Salazar-Martinez , EC Lazcano-Ponce , G Gonzalez Lira-Lira , P Escuerdo-De los Rios , M Hernandez-Avila . Nutritional determinants of epithelial ovarian cancer risk: a case–control study in Mexico. Oncology 2002; 63: 151–7.

31LH Kushi , PJ Mink , AR Folsom , KE Anderson , W Zheng , D Lazovich , . Prospective study of diet and ovarian cancer. American Journal of Epidemiology 1999; 149: 21–31.

32E Bidoli , C La Vecchia , M Montella , L Dal Maso , E Conti , E Negri , . Nutrient intake and ovarian cancer: an Italian case–control study. Cancer Causes & Control 2002; 13: 255–61.

33C Bosetti , E Negri , S Franceschi , C Pelucchi , R Talamini , M Montella , . Diet and ovarian cancer risk: a case–control study in Italy. International Journal of Cancer 2001; 93: 911–5.

34WC Willett , MJ Stampfer . Nutritional Epidemiology. New York: Oxford Univeristy Press, 1998.

35S Dickinson , JC Brand-Miller . Glycemic index, postprandial glycemia and cardiovascular disease. Current Opinion in Lipidology 2005; 16: 69–75.

36PC Colombani . Glycemic index and load – dynamic dietary guidelines in the context of diseases. Physiology & Behavior 2004; 83: 603–10.

37JC Brand-Miller . Glycemic load and chronic disease. Nutrition Reviews 2003; 61: S49–55.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: