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Haemoconcentration risk at the end of pregnancy: effects on neonatal behaviour

  • Nuria Aranda (a1) (a2), Carmen Hernández-Martínez (a3) (a2), Victoria Arija (a1) (a4) (a2), Blanca Ribot (a1) (a2) and Josefa Canals (a3) (a2)...
Abstract
Abstract Objective

To determine the associations between haemoconcentration at the end of pregnancy (third trimester and delivery) and neonatal behaviour in healthy pregnant women supplemented with moderate doses of Fe.

Design

A prospective longitudinal study in which obstetric and clinical history, maternal toxic habits, maternal anxiety and Hb levels were recorded at the third trimester and delivery. Neonatal behaviour was assessed at 48–72 h of age using the Neonatal Behavioral Assessment Scale.

Setting

Unit of Obstetrics and Gynaecology of the Sant Joan University Hospital in Reus, Tarragona (Spain).

Subjects

A total of 210 healthy and well-nourished pregnant women and their full-term, normal-weight newborns.

Results

The results showed that, after adjusting for confounders, in the third trimester the risk of haemoconcentration (6·2 % of pregnant women) was related to decreased neonatal state regulation (B=−1·273, P=0·006) and alertness (B=−1·848, P=0·006) scores. In addition, the risk of haemoconcentration at delivery (12·0 % of pregnant women) was also related to decreased neonatal state regulation (B=−0·796, P=0·021) and poor robustness and endurance (B=−0·921, P=0·005) scores.

Conclusions

Our results show that the risk of haemoconcentration at the end of pregnancy is related to the neonate’s neurodevelopment (and self-regulation capabilities), suggesting that Fe supplementation patterns and maternal Fe status during pregnancy are important factors for neurodevelopment which may be carefully controlled.

Copyright
Corresponding author
* Corresponding author: Email josefa.canals@urv.cat
Footnotes
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These authors contributed equally to this work.

Footnotes
Linked references
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2. N Aranda , B Ribot , E Garcia et al. (2011) Pre-pregnancy iron reserves, iron supplementation during pregnancy, and birth weight. Early Hum Dev 87, 791797.

4. B Ribot , N Aranda , F Viteri et al. (2012) Depleted iron stores without anaemia early in pregnancy carries increased risk of lower birthweight even when supplemented daily with moderate iron. Hum Reprod 27, 12601266.

6. BA Haider , I Olofin , M Wang et al. (2013) Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis. BMJ 346, f3443.

8. RA Thompson & CA Nelson (2001) Developmental science and the media: early brain development. Am Psychol 56, 515.

9. G Cucó , J Fernandez-Ballart , V Arija et al. (2005) Effect of B1-, B6- and iron intake during pregnancy on neonatal behavior. Int J Vitam Nutr Res 75, 320326.

10. C Hernández-Martínez , J Canals , N Aranda et al. (2011) Effects of iron deficiency on neonatal behavior at different stages of pregnancy. Early Hum Dev 87, 165169.

13. N Aranda , B Ribot , F Viteri et al. (2013) Predictors of haemoconcentration at delivery: association with low birth weight. Eur J Nutr 52, 16311639.

14. V Arija , B Ribot & N Aranda (2013) Prevalence of iron deficiency states and risk of haemoconcentration during pregnancy according to initial iron stores and iron supplementation. Public Health Nutr 16, 13711378.

15. P Aisen , G Cohen & JO Kang (1990) Iron toxicosis. Int Rev Exp Pathol 31, 146.

16. E Casanueva , F Viteri , M Mares-Galindo et al. (2006) Weekly iron as a safe alternative to daily supplementation for nonanemic pregnant women. Arch Med Res 37, 674–668.

17. E Papadopoulou , N Stratakis , T Roumeliotaki et al. (2013) The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother–child cohort study in Crete, Greece (Rhea study). Eur J Nutr 52, 326336.

18. AZ Khambalia , A Aimone , P Nagubandi et al. (2016) High maternal iron status, dietary iron intake and iron supplement use in pregnancy and risk of gestational diabetes mellitus: a prospective study and systematic review. Diabet Med 33, 12111221.

19. B Sandstrom (2001) Micronutrient interactions: effects on absorption and bioavailability. Br J Nutr 85, Suppl. 2, S181S185.

20. S Ziaei , M Norrozi , S Faghihzadeh et al. (2007) A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ≥13.2 g/dl. BJOG 114, 684688.

21. R Gaillard , PH Eilers , S Yassine et al. (2014) Risk factors and consequences of maternal anaemia and elevated haemoglobin levels during pregnancy: a population-based prospective cohort study. Paediatr Perinat Epidemiol 28, 213226.

23. P Steer , MA Alam , J Wadsworth et al. (1995) Relation between maternal haemoglobin concentration and birth weight in different ethnic groups. BMJ 310, 489491.

25. TG Cung , AS Paus , A Aghbar et al. (2014) Stillbirths at a hospital in Nablus, 2010: a cohort study. Glob Health Action 7, 25222.

26. PT Ellison (2010) Fetal programming and fetal psychology. Infant Child Dev 19, 620.

28. T Tamura , RL Goldenberg , J Hou et al. (2002) Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr 140, 165170.

29. S Hanieh , TT Ha , JA Simpson et al. (2013) The effect of intermittent antenatal iron supplementation on maternal and infant outcomes in rural Viet Nam: a cluster randomised trial. PLoS Med 10, e1001470.

30. C Hernández-Martínez , V Arija , A Balaguer et al. (2008) Do the emotional states of pregnant women affect neonatal behavior? Early Hum Dev 84, 745750.

31. C Hernández-Martínez , V Arija , J Escribano et al. (2010) Does maternal anxiety affect neonatal behaviour differently in boys and girls? Early Hum Dev 86, 209211.

32. S Conroy , CM Pariante , MN Marks et al. (2012) Maternal psychopathology and infant development at 18 months: the impact of maternal personality disorder and depression. J Am Acad Child Adolesc Psychiatry 51, 5161.

33. K Koutra , L Chatzi , T Roumeliotaki et al. (2012) Socio-demographic determinants of infant neurodevelopment at 18 months of age: Mother–Child Cohort (Rhea Study) in Crete, Greece. Infant Behav Dev 35, 4859.

34. Y Ding , X Xu , Z Wang et al. (2014) The relation of infant attachment to attachment and cognitive and behavioural outcomes in early childhood. Early Hum Dev 90, 459464.

35. CG Victora , BL Horta , CL de Mola et al. (2015) Association between breastfeeding and intelligence, educational attainment, and income at 30 years of age: a prospective birth cohort study from Brazil. Lancet Glob Health 3, e199e205.

36. RM Angulo-Barroso , L Schapiro , W Liang et al. (2011) Motor development in 9-month-old infants in relation to cultural differences and iron status. Dev Psychobiol 53, 196210.

37. C Hernández-Martínez , V Arija , J Escribano et al. (2012) A longitudinal study on the effects of maternal smoking and secondhand smoke exposure during pregnancy on neonatal neurobehavior. Early Hum Dev 88, 403408.

39. JN Dobbing & J Sands (1973) Quantitative growth and development of human brain. Arch Dis Child 48, 757767.

41. X Chen , TO Scholl & TP Stein (2006) Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women: the Camden study. Diabetes Care 29, 10771082.

42. M Rambod , CP Kovesdy & K Kalantar-Zadeh (2008) Combined high serum ferritin and low iron saturation in hemodialysis patients: the role of inflammation. Clin J Am Soc Nephrol 3, 16911701.

44. F Gomez , JM Simo , J Camps et al. (2000) Evaluation of a particle-enhanced turbidimetric immunoassay for the measurement of ferritin: application to patients participating in an autologous blood transfusion program. Clin Biochem 33, 191196.

51. N Aranda , FE Viteri , C Montserrat et al. (2010) Effects of C282Y, H63D, and S65C HFE gene mutations, diet, and life-style factors on iron status in a general Mediterranean population from Tarragona, Spain. Ann Hematol 89, 767773.

52. N Aranda , FE Viteri , J Fernández-Ballart et al. (2007) Frequency of the hemochromatosis gene (HFE) 282C→Y, 63H→D, and 65S→C mutations in a general Mediterranean population from Tarragona, Spain. Ann Hematol 86, 1721.

53. T Walsh , SD O’Broin , S Cooley et al. (2011) Laboratory assessment of iron status in pregnancy. Clin Chem Lab Med 49, 12251230.

57. M Debnath , G Venkatasubramanian & M Berk (2015) Fetal programming of schizophrenia: select mechanisms. Neurosci Biobehav Rev 49, 90104.

58. D Kingston , S McDonald , M Austin et al. (2015) Association between prenatal and postnatal psychological distress and toddler cognitive development: a systematic review. PLoS One 10, e126929.

59. V Glover (2014) Maternal depression, anxiety and stress during pregnancy and child outcome; what needs to be done. Best Pract Res Clin Obstet Gynaecol 28, 2535.

60. KJ O’Donnell , V Glover , ED Barker et al. (2014) The persisting effect of maternal mood in pregnancy on childhood psychopathology. Dev Psychopathol 26, 393403.

62. J Canals , C Hernández-Martínez , G Esparó et al. (2011) Neonatal Behavioral Assessment Scale as a predictor of cognitive development and IQ in full-term infants: a 6-year longitudinal study. Acta Paediatr 100, 13311337.

63. J Canals , G Esparó & JD Fernández-Ballart (2006) Neonatal behaviour characteristics and psychological problems at 6 years. Acta Paediatr 95, 14121417.

64. DJ Barker (1998) In utero programming of chronic disease. Clin Sci (Lond) 95, 115128.

66. DB Kim-Shapiro , AN Schechter & MT Gladwin (2006) Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics. Arterioscler Thromb Vasc Biol 26, 697705.

67. L Sun , CK Macgowan , JG Sled et al. (2015) Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease. Circulation 131, 13131323.

68. PB Walter , MD Knutson , A Paler-Martinez et al. (2002) Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats. Proc Natl Acad Sci U S A 99, 22642269.

69. FE Viteri , E Casanueva , MC Tolentino et al. (2012) Antenatal iron supplements consumed daily produce oxidative stress in contrast to weekly supplementation in Mexican non-anemic women. Reprod Toxicol 34, 125132.

71. Y Shen , HM Yu , TM Yuan et al. (2007) Intrauterine infection induced oligodendrocyte injury and inducible nitric oxide synthase expression in the developing rat brain. J Perinat Med 35, 203209.

72. B Ribot , N Aranda , M Giralt et al. (2013) Effect of different doses of iron supplementation during pregnancy on maternal and infant health. Ann Hematol 92, 221229.

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Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
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