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Legume consumption and CVD risk: a systematic review and meta-analysis

  • Stefano Marventano (a1), Maria Izquierdo Pulido (a2) (a3), Claudia Sánchez-González (a4), Justyna Godos (a5), Attilio Speciani (a6), Fabio Galvano (a5) and Giuseppe Grosso (a7)...
Abstract
Abstract Objective

The aim of the present study was to systematically review and perform a meta-analysis of prospective cohort studies exploring the association between dietary legume consumption and CVD risk, including CHD and stroke.

Design

The PubMed and EMBASE databases were searched up to December 2015. A meta-analysis of the highest v. lowest (reference) category of dietary legume consumption was performed through random-effects models.

Results

Fourteen studies conducted on eleven cohorts and accounting for a total of 367 000 individuals and 18 475 cases of CVD (7451 CHD and 6336 stroke cases) were considered for the analyses. Compared with lower legume consumption, the highest category of exposure was associated with a decreased risk of 10 % in both CVD and CHD (relative risk=0·90; 95 % CI 0·84, 0·97) with no or little evidence of heterogeneity and no publication bias. Null results were found regarding legume consumption and stroke risk. No substantial confounding factors were evident in stratified analyses.

Conclusions

Legume consumption was associated with lower risk of CVD. Legumes’ intrinsic characteristics, because they are often part of an overall healthy diet, or because they are a substitute for unhealthy sources of protein may potentially explain the current findings.

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Copyright
Corresponding author
* Corresponding author: Email stefano.marventano@studium.unict.it
References
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1. WongND (2014) Epidemiological studies of CHD and the evolution of preventive cardiology. Nat Rev Cardiol 11, 276289.
2. SalomonJA, WangH, FreemanMK et al. (2012) Healthy life expectancy for 187 countries, 1990–2010: a systematic analysis for the Global Burden Disease Study 2010. Lancet 380, 21442162.
3. FormanD & BulwerBE (2006) Cardiovascular disease: optimal approaches to risk factor modification of diet and lifestyle. Curr Treat Options Cardiovasc Med 8, 4757.
4. GrossoG, MistrettaA, FrigiolaA et al. (2014) Mediterranean diet and cardiovascular risk factors: a systematic review. Crit Rev Food Sci Nutr 54, 593610.
5. SofiF, MacchiC, AbbateR et al. (2014) Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public Health Nutr 17, 27692782.
6. GrossoG, MistrettaA, MarventanoS et al. (2014) Beneficial effects of the Mediterranean diet on metabolic syndrome. Curr Pharm Des 20, 50395044.
7. HirotaniY, OzakiN, TsujiY et al. (2015) Effects of eicosapentaenoic acid on hepatic dyslipidemia and oxidative stress in high fat diet-induced steatosis. Int J Food Sci Nutr 66, 569573.
8. BahadoranZ, MirmiranP, TohidiM et al. (2015) Dietary phytochemical index and the risk of insulin resistance and β-cell dysfunction: a prospective approach in Tehran lipid and glucose study. Int J Food Sci Nutr 66, 950955.
9. StedileN, CanutoR, de ColCD et al. (2016) Dietary total antioxidant capacity is associated with plasmatic antioxidant capacity, nutrient intake and lipid and DNA damage in healthy women. Int J Food Sci Nutr 67, 479488.
10. BouchenakM & Lamri-SenhadjiM (2013) Nutritional quality of legumes, and their role in cardiometabolic risk prevention: a review. J Med Food 16, 185198.
11. GuineRP, FerreiraM, CorreiaP et al. (2016) Knowledge about dietary fibre: a fibre study framework. Int J Food Sci Nutr 67, 707714.
12. BercianoS & OrdovasJM (2014) Nutrition and cardiovascular health. Rev Esp Cardiol (Engl Ed) 67, 738747.
13. AfshinA, MichaR, KhatibzadehS et al. (2014) Consumption of nuts and legumes and risk of incident ischemic heart disease, stroke, and diabetes: a systematic review and meta-analysis. Am J Clin Nutr 100, 278288.
14. ShiZQ, TangJJ, WuH et al. (2014) Consumption of nuts and legumes and risk of stroke: a meta-analysis of prospective cohort studies. Nutr Metab Cardiovasc Dis 24, 12621271.
15. GrossoG, MarventanoS, YangJ et al. (2015) A comprehensive meta-analysis on evidence of Mediterranean diet and cardiovascular disease: are individual components equal? Crit Rev Food Sci Nutr (Epublication ahead of print version).
16. WellsGA, SheaB, O’ConnellD et al. (1999) The Newcastle–Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Ottawa: Ottawa Health Research Institute.
17. BazzanoLA, HeJ, OgdenLG et al. (2001) Legume consumption and risk of coronary heart disease in US men and women: NHANES I Epidemiologic Follow-up Study. Arch Intern Med 161, 25732578.
18. KelemenLE, KushiLH, JacobsDRJr et al. (2005) Associations of dietary protein with disease and mortality in a prospective study of postmenopausal women. Am J Epidemiol 161, 239249.
19. KokuboY, IsoH, IshiharaJ et al. (2007) Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I. Circulation 116, 25532562.
20. BucklandG, GonzalezCA, AgudoA et al. (2009) Adherence to the Mediterranean diet and risk of coronary heart disease in the Spanish EPIC cohort study. Am J Epidemiol 170, 15181529.
21. MizrahiA, KnektP, MontonenJ et al. (2009) Plant foods and the risk of cerebrovascular diseases: a potential protection of fruit consumption. Br J Nutr 102, 10751083.
22. NaguraJ, IsoH, WatanabeY et al. (2009) Fruit, vegetable and bean intake and mortality from cardiovascular disease among Japanese men and women: the JACC Study. Br J Nutr 102, 285292.
23. BernsteinAM, SunQ, HuFB et al. (2010) Major dietary protein sources and risk of coronary heart disease in women. Circulation 122, 876883.
24. Martinez-GonzalezMA, Garcia-LopezM, Bes-RastrolloM et al. (2011) Mediterranean diet and the incidence of cardiovascular disease: a Spanish cohort. Nutr Metab Cardiovasc Dis 21, 237244.
25. DilisV, KatsoulisM, LagiouP et al. (2012) Mediterranean diet and CHD: the Greek European Prospective Investigation into Cancer and Nutrition cohort. Br J Nutr 108, 699709.
26. BernsteinAM, PanA, RexrodeKM et al. (2012) Dietary protein sources and the risk of stroke in men and women. Stroke 43, 637644.
27. MisirliG, BenetouV, LagiouP et al. (2012) Relation of the traditional Mediterranean diet to cerebrovascular disease in a Mediterranean population. Am J Epidemiol 176, 11851192.
28. HaringB, GronroosN, NettletonJA et al. (2014) Dietary protein intake and coronary heart disease in a large community based cohort: results from the Atherosclerosis Risk in Communities (ARIC) study [corrected]. PLoS One 9, e109552.
29. HaringB, MisialekJR, RebholzCM et al. (2015) Association of dietary protein consumption with incident silent cerebral infarcts and stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Stroke 46, 34433450.
30. NouriF, SarrafzadeganN, MohammadifardN et al. (2016) Intake of legumes and the risk of cardiovascular disease: frailty modeling of a prospective cohort study in the Iranian middle-aged and older population. Eur J Clin Nutr 70, 217221.
31. SinghalP, KaushikG & MathurP (2014) Antidiabetic potential of commonly consumed legumes: a review. Crit Rev Food Sci Nutr 54, 655672.
32. SouzaRG, GomesAC, NavesMM et al. (2015) Nuts and legume seeds for cardiovascular risk reduction: scientific evidence and mechanisms of action. Nutr Rev 73, 335347.
33. AndersonJW & BushHM (2011) Soy protein effects on serum lipoproteins: a quality assessment and meta-analysis of randomized, controlled studies. J Am Coll Nutr 30, 7991.
34. YangB, ChenY, XuT et al. (2011) Systematic review and meta-analysis of soy products consumption in patients with type 2 diabetes mellitus. Asia Pac J Clin Nutr 20, 593602.
35. SchonfeldG (2010) Plant sterols in atherosclerosis prevention. Am J Clin Nutr 92, 34.
36. YangY, ZhaoLG, WuQJ et al. (2015) Association between dietary fiber and lower risk of all-cause mortality: a meta-analysis of cohort studies. Am J Epidemiol 181, 8391.
37. SatijaA & HuFB (2012) Cardiovascular benefits of dietary fiber. Curr Atheroscler Rep 14, 505514.
38. MarventanoS, KolaczP, CastellanoS et al. (2015) A review of recent evidence in human studies of n-3 and n-6 PUFA intake on cardiovascular disease, cancer, and depressive disorders: does the ratio really matter? Int J Food Sci Nutr 66, 611622.
39. RebelloCJ, GreenwayFL & FinleyJW (2014) A review of the nutritional value of legumes and their effects on obesity and its related co-morbidities. Obes Rev 15, 392407.
40. MalagutiM, DinelliG, LeonciniE et al. (2014) Bioactive peptides in cereals and legumes: agronomical, biochemical and clinical aspects. Int J Mol Sci 15, 2112021135.
41. EstruchR, RosE, Salas-SalvadoJ et al. (2013) Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 368, 12791290.
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