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A dose–response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk

  • Nai-Hui Sun (a1), Xuan-Zhang Huang (a2), Shuai-Bo Wang (a3), Yuan Li (a2), Long-Yi Wang (a2), Hong-Chi Wang (a2), Chang-Wang Zhang (a2), Cong Zhang (a2), Hong-Peng Liu (a2) and Zhen-Ning Wang (a2)...
Abstract
Objective

The current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.

Design

The PubMed and EMBASE databases were searched. A dose–response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.

Setting

The meta-analysis included seventeen studies.

Subjects

A total of 10 601 patients.

Results

The non-linear dose–response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose–response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).

Conclusions

Our meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only.

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Corresponding author
* Corresponding author: Email josieon826@sina.cn
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