Skip to main content
×
Home

The duration of obesity and the risk of type 2 diabetes

  • Asnawi Abdullah (a1) (a2), Johannes Stoelwinder (a1), Susan Shortreed (a1), Rory Wolfe (a1), Christopher Stevenson (a1), Helen Walls (a1), Maximilian de Courten (a1) and Anna Peeters (a1)...
Abstract
AbstractObjective

The evidence for the association between obesity and the risk of type 2 diabetes has been derived mainly from the analysis of the degree of obesity. The role of the duration of obesity as an independent risk has not been fully explored. The objective of the present study was to investigate the association between the duration of obesity and the risk of type 2 diabetes.

Design

Prospective cohort study.

Setting

The Framingham Heart Study (FHS), follow-up from 1948 to 1998.

Subjects

A total of 1256 FHS participants who were free from type 2 diabetes at baseline, but were obese on at least two consecutive of the study’s twenty-four biennial examinations, were included. Type 2 diabetes status was collected throughout the 48 years of follow-up of the study. The relationship between duration of obesity and type 2 diabetes was analysed using time-dependent Cox models, adjusting for a number of covariates.

Results

The unadjusted hazard ratio (HR) for the risk of type 2 diabetes for men was 1·13 (95 % CI 1·09, 1·17) and for women was 1·12 (95 % CI 1·08, 1·16) per additional 2-year increase in the duration of obesity. Adjustment for sociodemographic variables, family history of diabetes, health behaviour and physical activity made little difference to these HR. For women the evidence of a dose–response relationship was less clear than for men, particularly for women with an older age at obesity onset.

Conclusions

The duration of obesity is a relevant risk factor for type 2 diabetes, independent of the degree of BMI.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The duration of obesity and the risk of type 2 diabetes
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      The duration of obesity and the risk of type 2 diabetes
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      The duration of obesity and the risk of type 2 diabetes
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Email Asnawi.Abdullah@med.monash.edu.au
References
Hide All
1.World Health Organization (2008) The Global Burden of Disease: 2004 Update. Switzerland: WHO.
2.Lee JM, Pilli S, Gebremariam A et al. (2010) Getting heavier, younger: trajectories of obesity over the life course. Int J Obes 34, 614623.
3.Peto R (1986) Influence of dose and duration of smoking on lung cancer rates. IARC Sci Publ 74, 2333.
4.Doll R & Peto R (1978) Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers. J Epidemiol Community Health 32, 303313.
5.Everhart JE, Pettitt DJ, Bennett PH et al. (1992) Duration of obesity increases the incidence of NIDDM. Diabetes 41, 235240.
6.Pontiroli AE & Galli L (1998) Duration of obesity is a risk factor for non-insulin-dependent diabetes mellitus, not for arterial hypertension or for hyperlipidaemia. Acta Diabetologica 35, 130136.
7.Sakurai Y, Teruya K, Shimada N et al. (1999) Association between duration of obesity and risk of non-insulin-dependent diabetes mellitus. The Sotetsu Study. Am J Epidemiol 149, 256260.
8.Wannamethee SG & Shaper AG (1999) Weight change and duration of overweight and obesity in the incidence of type 2 diabetes. Diabetes Care 22, 12661272.
9.Hekimsoy Z & Oktem IK (2003) Duration of obesity is not a risk factor for type 2 diabetes mellitus, arterial hypertension and hyperlipidemia. Diabetes Obes Metab 5, 432437.
10.Holbrook TL, Barrett-Connor E & Wingard DL (1989) The association of lifetime weight and weight control patterns with diabetes among men and women in an adult community. Int J Obes 13, 723729.
11.Perry GS, Byers TE, Mokdad AH et al. (1995) The validity of self-reports of past body weights by US adults. Epidemiology 6, 6166.
12.Tamakoshi K, Yatsuya H, Kondo T et al. (2003) The accuracy of long-term recall of past body weight in Japanese adult men. Int J Obes Relat Metab Disord 27, 247252.
13.Leach JD (2008) So Go the Pimas, So Go the Rest of Us. General Interest Article. New Orleans, LA: Paleobiotics Lab; available at http://www.paleobioticslab.com/pima_diabetes.htm
14.National Heart Institute (1968) The Framingham Study: An Epidemiological Investigation of Cardiovascular Disease. Bethesda, MD: National Institutes of Health.
15.Dawber TR, Meadors GF & Moore FE Jr (1951) Epidemiological approaches to heart disease: The Framingham Study. Am J Public Health Nations Health 41, 279286.
16.Kannel WB & Sorlie P (1979) Some health benefits of physical activity. The Framingham Study. Arch Intern Med 139, 857861.
17.World Health Organization (2006) Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia: Report of a WHO/IDF Consultation. Geneva: WHO.
18.Fisher LD & Lin DY (1999) Time-dependent covariates in the Cox proportional-hazards regression model. Annu Rev Public Health 20, 145157.
19.StataCorp LP (2007) Stata Survival Analysis and Epidemiological Tables Reference Manual Release 10. College Station, TX: Stata Corporation.
20.Booth ML, Dobbins T, Okely AD et al. (2007) Trends in the prevalence of overweight and obesity among young Australians, 1985, 1997, and 2004. Obesity (Silver Spring) 15, 10891095.
21.Felber JP, Golay A, Jequier E et al. (1988) The metabolic consequences of long-term human obesity. Int J Obes 12, 377389.
22.Groop LC & Eriksson JG (1992) The etiology and pathogenesis of non-insulin-dependent diabetes. Ann Med 24, 483489.
23.Carlsson S, Persson PG, Alvarsson M et al. (1998) Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men. Am J Epidemiol 148, 539545.
24.Geer EB & Shen W (2009) Gender differences in insulin resistance, body composition, and energy balance. Gend Med 6, Suppl. 1, 6075.
25.Blaak E (2001) Gender differences in fat metabolism. Curr Opin Clin Nutr Metab Care 4, 499502.
26.Centers for Disease Control and Prevention, National Center for Health Statistics (2002) National Health and Nutrition Examination Survey. Atlanta, GA: CDC.
27.Centers for Disease Control and Prevention (2008) State-specific prevalence of obesity among adults – United States. MMWR 57, 765768.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 21
Total number of PDF views: 157 *
Loading metrics...

Abstract views

Total abstract views: 395 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 17th November 2017. This data will be updated every 24 hours.