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    Bosse, John D and Dixon, Brian M 2012. Dietary protein in weight management: a review proposing protein spread and change theories. Nutrition & Metabolism, Vol. 9, Issue. 1, p. 81.


    Hashimoto, Y. Fukuda, T. Oyabu, C. Tanaka, M. Asano, M. Yamazaki, M. and Fukui, M. 2016. Impact of low-carbohydrate diet on body composition: meta-analysis of randomized controlled studies. Obesity Reviews, Vol. 17, Issue. 6, p. 499.


    Rietman, A Schwarz, J Tomé, D Kok, F J and Mensink, M 2014. High dietary protein intake, reducing or eliciting insulin resistance?. European Journal of Clinical Nutrition, Vol. 68, Issue. 9, p. 973.


    Alves, Raquel Duarte Moreira de Oliveira, Fernanda Cristina Esteves Hermsdorff, Helen Hermana Miranda Abete, Itziar Zulet, María Ángeles Martínez, José Alfredo and Bressan, Josefina 2014. Eating carbohydrate mostly at lunch and protein mostly at dinner within a covert hypocaloric diet influences morning glucose homeostasis in overweight/obese men. European Journal of Nutrition, Vol. 53, Issue. 1, p. 49.


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Effectiveness of energy-restricted diets with different protein:carbohydrate ratios: the relationship to insulin sensitivity

Abstract
AbstractObjective

Insulin sensitivity could determine the effectiveness of weight-loss diets with different protein:carbohydrate ratios. Our aim was to evaluate whether or not energy-restricted diets with different protein:carbohydrate ratios in obese individuals with (IR) or without (IS) insulin resistance could lead to differences in weight loss or insulin sensitivity.

Design

Prospective, randomized, clinical intervention study. Thirty-six obese patients, allocated to the IR or IS group after a 75 g oral glucose tolerance test and calculation of the homeostasis model assessment of insulin resistance (HOMA) index, were assigned to follow an energy-restricted diet with either 40 % carbohydrate/30 % protein/30 % fat (diet A) or 55 % carbohydrate/15 % protein/30 % fat (diet B) and followed up to 16 weeks.

Results

Twenty-one IR and fifteen IS patients were randomized to diet A or B. After 16 weeks, there was no difference in weight loss between diets A and B in each group. Glucose and insulin levels and HOMA were significantly reduced at 16 weeks, but no differences related to the type of diet were detected either in the IR or the IS group.

Conclusions

Varying the macronutrient composition of a hypoenergetic diet, regarding the percentage protein:carbohydrate ratio, did not produce different weight loss or result in an improvement in insulin sensitivity in people with or without insulin resistance.

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*Corresponding author: Email mdballesteros@telefonica.net
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2.DM Bravata , L Sanders , J Huang (2003) Efficacy and safety of low-carbohydrate diets. JAMA 289, 18371850.

3.L Stern , N Iqbal , P Seshadri (2004) The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med 140, 778785.

4.GD Foster , HR Wyatt , JO Hill (2003) A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med 348, 20822090.

5.WS Yancy , MK Olsen , JR Guyton (2004) A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia. Ann Intern Med 140, 769777.

6.BJ Brehm , RJ Seeley , SR Daniels (2003) A randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women. J Clin Endocrinol Metab 88, 16171623.

8.AJ Nordmann , A Nordmann , M Briel (2006) Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med 166, 285293.

9.ML Dansinger , JA Gleason , JL Griffith (2005) Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 293, 4353.

10.FM Sacks , GA Bray , VJ Carey (2009) Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med 360, 859873.

11.MA Cornier , WT Donahoo , R Pereira (2005) Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women. Obes Res 13, 703709.

12.JF Ascaso , P Romero , JT Real (2001) Insulin resistance quantification by fasting insulin plasma values and HOMA index in a non-diabetic population. Med Clin (Barc) 117, 530553.

13.T McLaughlin , F Abbasi , M Carantoni (1999) Differences in insulin resistance do not predict weight loss in response to hypocaloric diets in healthy obese women. J Clin Endocrinol Metab 84, 578581.

16.ND Luscombe , PM Clifton , M Noakes (2003) Effect of a high-protein, energy-restricted diet on weight loss and energy expenditure after weight stabilization in hyperinsulinemic subjects. Int J Obes Relat Metab Disord 27, 582590.

18.T McLaughlin , F Abbasi , K Cheal (2003) Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 139, 802809.

21.MS Westerterp-Plantenga (2003) The significance of protein in food intake and body weight regulation. Curr Opin Clin Nutr Metab Care 6, 635638.

22.AR Skov , S Toubro , B Ronn (1999) Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity. Int J Obes Relat Metab Disord 23, 528536.

24.A Pietrobelli , DB Allison , S Heshka (2002) Sexual dimorphism in the energy content of weight change. Int J Obes Relat Metab Disord 26, 13391348.

25.E Ferrannini & A Mari (1998) How to measure insulin sensitivity. J Hypertens 16, 895906.

26.TL McLaughlin & GM Reaven (2003) Beyond type 2 diabetes: the need for a clinically useful way to identify insulin resistance. Am J Med 114, 501502.

27.G Pacini & A Mari (2003) Methods for clinical assessment of insulin sensitivity and β-cell function. Best Pract Res Clin Endocrinol Metab 17, 305322.

28.CB Ebbeling , MM Leidig , HA Feldman (2007) Effects of a low-glycemic load vs low-fat diet in obese young adults. A randomized trial. JAMA 297, 20922102.

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Public Health Nutrition
  • ISSN: 1368-9800
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