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Fruit and vegetable consumption and risk of colorectal cancer in Japan: The Miyagi Cohort Study

Published online by Cambridge University Press:  02 January 2007

Yuki Sato ,
Yoshitaka Tsubono ,
Naoki Nakaya ,
Keiko Ogawa ,
Kayoko Kurashima ,
Shinichi Kuriyama ,
Atsushi Hozawa ,
Yoshikazu Nishino ,
Daisuke Shibuya  and
Ichiro Tsuji
Yuki Sato*
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
Yoshitaka Tsubono
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
Naoki Nakaya
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
Keiko Ogawa
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
Kayoko Kurashima
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
Shinichi Kuriyama
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
Atsushi Hozawa
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
Yoshikazu Nishino
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
Daisuke Shibuya
Affiliation:
Miyagi Cancer Society, Sendai, Japana
Ichiro Tsuji
Affiliation:
Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan:
*
*Corresponding author: Email syukiki@mail.tains.tohoku.ac.jp
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Abstract

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Objective

Adequate fruit and vegetable intake has been suggested to protect against colorectal cancer. However, several recent prospective studies have reported no association. We therefore examined the association between fruit and vegetable intakes and the risk of colorectal cancer in a prospective cohort study in Japan.

Design

Between June and August 1990, 47 605 Japanese men and women completed a self-administered questionnaire, including a food-frequency questionnaire. We divided the subjects into quartiles based on their self-reported fruit and vegetable consumption. There were 165 colon cancer and 110 rectal cancer incidences identified during 7 years of follow-up, to the end of December 1997. We used Cox proportional hazards models to estimate the relative risk (RR) of developing colorectal cancer according to the level of fruit and vegetable consumption, applying adjustments for potential confounders.

Results

No statistically significant association was observed between fruit and vegetable consumption and the risk of colorectal cancer. The multivariate RR of colon cancer in the highest quartile of fruit and vegetable intake compared with the lowest was 1.13 (95% confidence interval (CI) 0.73–1.75), the RR for vegetables alone was 1.24 (95% CI 0.79–1.95) and that for fruit alone was 1.45 (95% CI 0.85–2.47). The corresponding multivariate RRs for rectal cancer were 1.12 (95% CI 0.67–1.89), 1.14 (95% CI 0.67–1.93) and 1.41 (95% CI 0.73–2.73).

Conclusions

We found no association between the consumption of fruit and vegetables and the risk of colorectal cancer among the Japanese population.

Keywords

Colorectal cancerFood-frequency questionnaireProspective cohort studyVegetablesFruit
Type
Research Article
Information
Public Health Nutrition , Volume 8 , Issue 3 , May 2005 , pp. 309 - 314
Copyright
Copyright © The Authors 2005

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