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Milk as a food for growth? The insulin-like growth factors link

  • Imogen Rogers (a1), Pauline Emmett (a1), David Gunnell (a2), David Dunger (a3) and Jeff Holly (a4)
  • DOI: http://dx.doi.org/10.1079/PHN2006853
  • Published online: 01 January 2007
Abstract
AbstractObjective

The mechanisms underlying the association of insulin-like growth factor-I (IGF-I) and leg length (a marker of prepubertal growth) with cancer risk are uncertain. One hypothesis is that diet in early childhood might provide the link. The aim of the present study was to examine the association between early diet – in particular, the intakes of cows' milk and dairy products – and height, leg length and IGF-I levels at age 7–8 years.

Subjects

Children participating in the Avon Longitudinal Study of Parents and Children.

Design

Diet was assessed using a 3-day unweighed food record. Anthropometry, IGF-I and insulin-like growth factor-binding protein-3 (IGFBP-3) were measured by standard methods.

Results

Data on both diet and height were available for 744 children (404 boys) and on diet and IGF for 538 (295 boys). After adjusting for energy, both cows' milk and dairy product intakes were positively associated with IGF-I (P=0.040 and 0.027, respectively) and IGFBP-3 levels (P=0.082 and 0.067, respectively). These associations persisted on adjustment for potential confounders, but were abolished on controlling for protein intake. In energy-adjusted models there was only weak evidence of associations of milk and dairy product intakes with anthropometry. In boys only, dairy product intake was positively associated with leg length (equivalent to a 0.058 (0.002, 0.114) standard deviation score increase in leg length per 100 g increase in daily intake).

Conclusions

These data provide some evidence that variation in childhood milk and dairy product intakes underlies associations of leg length, IGF-I and cancer risk. The association appears to be due to the protein content of milk.

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*Corresponding author: Email Imogen.Rogers@bristol.ac.uk
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1D Gunnell , M Okasha , G Davey Smith , S Oliver , J Sandhu , J Holly . Height, leg length, and cancer risk: a systematic review. Epidemiologic Reviews 2001; 23: 313–42.

2W Gerver , R Bruin . Relationship between height, sitting height and subischial leg length in Dutch children: presentation of normal values. Acta Paediatrica 1995; 84: 532–5.

3D Gunnell , G Davey Smith , J Holly , S Frankel . Leg length and risk of cancer in the Boyd Orr cohort. British Medical Journal 1998; 317: 1350–1.

4D Gunnell . Commentary: Can adult anthropometry be used as a ‘biomarker’ for prenatal and childhood exposures? International Journal of Epidemiology 2002; 31: 390–4.

5A Butler , D Le Roith . Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles. Annual Review of Physiology 2001; 63: 141–64.

6A Juul , P Dalgaard , W Blum . Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index and pubertal maturation. Journal of Clinical Endocrinology and Metabolism 1995; 80: 2534–42.

7J Chan , M Stampfer , E Giovannucci , PH Gann , J Ma , P Wilkinson , Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study. Science 1998; 279: 563–6.

8A Wolk , CS Mantzoros , SO Andersson , R Bergstrom , LB Signorello , P Lagiou , Insulin-like growth factor I and prostate cancer risk: a population-based case-control study. Journal of the National Cancer Institute 1998; 90: 911–5.

9S Hankinson , W Willett , G Colditz , D Hunter , D Michaud , B Deroo , Circulating concentrations of insulin-like growth factor I and risk of breast cancer. Lancet 1998; 351: 1393–6.

10J Ma , E Giovannucci , M Pollak , J Chan , J Gaziano , W Willett , Milk intake, circulating levels of insulin-like growth factor-I, and risk of colorectal cancer in men. Journal of the National Cancer Institute 2001; 93: 1330–6.

11H Yu , T Rohan . Role of the insulin-like growth factor family in cancer development and progression. Journal of the National Cancer Institute 2000; 92: 1472–89.

13A Renehan , M Zwahler , C Minder , S O'Dwyer , S Shalet , M Egger . Insulin-like growth factor (IGF)-I, IGF binding protein 3 and cancer risk: systematic review and meta-regression analysis. Lancet 2004; 363: 1346–53.

16L Kolonel . Fat, meat and prostate cancer. Epidemiologic Reviews 2001; 23: 7281.

17J Chan , E Giovannucci . Dairy products, calcium, vitamin D and risk of prostate cancer. Epidemiologic Reviews 2001; 23: 8792.

19A Trichopoulou , K Katsouyanni , S Stuver , L Tzala , C Gnardellis , E Rimm , Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece. Journal of the National Cancer Institute 1995; 87: 110–6.

20J Chan , E Giovannucci . Vegetables, fruits, associated micronutrients and risk of prostate cancer. Epidemiologic Reviews 2001; 23: 82–6.

21JL Freudenheim , J Marshall , J Vena , J Laughlin , J Brasure , M Swanson , Premenopausal breast cancer risk and intake of vegetables, fruits and related nutrients. Journal of the National Cancer Institute 1996; 88: 340–8.

22T Key , N Allen , E Spencer , R Travis . The effect of diet on risk of cancer. Lancet 2002; 360: 861–8.

24D Gunnell , S Oliver , T Peters , J Donovan , R Persad , M Maynard , Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-I and IGFBP-3 in middle-aged men. British Journal of Cancer 2003; 88: 1682–6.

27L Signorello , H Kuper , P Lagiou , L Mucci , D Trichopoulos , HO Adami . Lifestyle factors and insulin-like growth factor I levels among elderly men. European Journal of Cancer Prevention 2000; 9: 173–8.

28L Mucci , R Tamimi , P Lagiou , A Trichopoulou , V Benetou , E Spanos , Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system? BJU International 2001; 87: 814–20.

29RP Heaney , D McCarron , B Dawson-Huges , S Oparil , S Berga , J Stern , Dietary changes favorably affect bone remodeling in older adults. Journal of the American Dietetic Association 1999; 99: 1228–33.

30J Cadogan , R Eastell , N Jones , M Barker . Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial. British Medical Journal 1997; 315: 1255–60.

31C Hoppe , C Mølgaard , A Juul , K Michaelsen . High intakes of skimmed milk, but not meat, increase serum IGF-I and IGFBP-3 in eight-year-old boys. European Journal of Clinical Nutrition 2004; 58: 1211–6.

32S Frankel , DJ Gunnell , TJ Peters , M Maynard , G Davey Smith . Childhood energy intake and adult mortality from cancer: the Boyd Orr Cohort Study. British Medical Journal 1998; 316: 499504.

34J Golding , M Pembrey , R Jones . ALSPAC Study Team. ALSPAC – The Avon Longitudinal Study of Parents and Children. I. Study methodology. Paediatric and Perinatal Epidemiology 2001; 15: 7487.

36GM Price , AA Paul , FB Key , AC Harter , TJ Cole , KC Day , Measurement of diet in a large national survey: comparison of computerised and manual coding of records in household measures. Journal of Human Nutrition and Dietetics 1995; 8: 417–28.

50S Garnett , C Cowell , D Bradford , J Lee , C Tao , V Petrauskas , Effects of gender, body composition and birth size on IGF-I in 7- and 8-year-old children. Hormone Research 1999; 52: 221–9.

52JV Freeman , TJ Cole , S Chinn , PRM Jones , EM White , MA Preece . Cross sectional stature and weight reference curves for the UK, 1990. Archives of Disease in Childhood 1995; 73: 1724.

53D Gunnell , SE Oliver , JL Donovan , TJ Peters , D Gillatt , R Persad , Do height-related variations in insulin-like growth factors underlie the associations of stature with adult chronic disease? Journal of Clinical Endocrinology and Metabolism 2004; 89: 213–8.

56J Thissen , J Ketelslegers , L Underwood . Nutritional regulation of the insulin-like growth factors. Endocrine Reviews 1994; 15: 80101.

57A Juul , F Scheike , M Davidsen , J Gyllenborg , T Jorgensen . Low serum insulin-like growth factor I is associated with increased risk of ischaemic heart disease. Circulation 2002; 106: 939–44.

58M Sandhu , A Heald , J Gibson , J Cruickshank , DB Dunger , N Wareham . Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study. Lancet 2002; 359: 1740–5.

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