Skip to main content
×
×
Home

Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study

  • Amy Moore (a1), Hagit Hochner (a2), Colleen M Sitlani (a3), Michelle A Williams (a4), Andrew N Hoofnagle (a5) (a6), Ian H de Boer (a1) (a6), Bryan Kestenbaum (a1) (a6), David S Siscovick (a1) (a3) (a6), Yechiel Friedlander (a2) and Daniel A Enquobahrie (a1) (a3) (a7)...
Abstract
Objective

To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults.

Design

Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC–tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors.

Setting

Individuals born in Jerusalem during 1974–1976.

Subjects

Participants of the Jerusalem Perinatal Study (n 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity.

Results

Mean total 25(OH)D concentration among participants was 21·7 (sd 8·9) ng/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, β=−0·011, P=0·004) after adjustment for BMI. However, these associations were not present among females (P for sex interaction=0·005).

Conclusions

We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Email danenq@uw.edu
References
Hide All
1. Holick, MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80, 6 Suppl., 1678S16788S.
2. Cranney, A, Weiler, H, O’Donnell, S et al. (2008) Summary of evidence-based review on vitamin D efficacy and safety in relation to bone health. Am J Clin Nutr 88, issue 2, 513S519S.
3. Holick, MF (2007) Vitamin D deficiency. N Engl J Med 357, 266281.
4. Giovannucci, E, Liu, Y, Hollis, B et al. (2008) 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med 168, 11741180.
5. Zittermann, A, Gummert, JF & Borgermann, J (2009) Vitamin D deficiency and mortality. Curr Opin Clin Nutr Metab Care 12, 634639.
6. Wang, TJ, Pencina, MJ, Booth, SL et al. (2008) Vitamin D deficiency and risk of cardiovascular disease. Circulation 117, 503511.
7. Judd, SE & Tangpricha, V (2009) Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci 338, 4044.
8. Fiscella, K & Franks, P (2010) Vitamin D, race, and cardiovascular mortality: findings from a national US sample. Ann Fam Med 8, 1118.
9. van Lennep, JER, Westerveld, HT, Erkelens, DW et al. (2002) Risk factors for coronary heart disease: implications of gender. Cardiovasc Res 53, 538549.
10. Hochner, H, Friedlander, Y, Calderon-Margalit, R et al. (2012) Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the Jerusalem Perinatal Family Follow-up Study. Circulation 125, 13811389.
11. Holick, MF, Binkley, NC, Bischoff-Ferrari, HA et al. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96, 19111930.
12. Jorde, R & Grimnes, G (2011) Vitamin D and metabolic health with special reference to the effect of vitamin D on serum lipids. Prog Lipid Res 50, 303312.
13. Kayaniyil, S, Vieth, R, Harris, SB et al. (2011) Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components. J Clin Endocrinol Metab 96, 168175.
14. Zittermann, A, Frisch, S, Berthold, HK et al. (2009) Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr 89, 13211327.
15. Jorde, R, Sneve, M, Torjesen, P et al. (2010) No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med 267, 462472.
16. Heikkinen, A-M, Tuppurainen, MT, Niskanen, L et al. (1997) Long-term vitamin D3 supplementation may have adverse effects on serum lipids during postmenopausal hormone replacement therapy. Eur J Endocrinol 137, 495502.
17. Andersen, R, Brot, C, Mejborn, H et al. (2009) Vitamin D supplementation does not affect serum lipids and lipoproteins in Pakistani immigrants. Eur J Clin Nutr 63, 11501153.
18. Nagpal, J, Pande, JN & Bhartia, A (2009) A double-blind, randomized, placebo-controlled trial of the short-term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle-aged, centrally obese men. Diabet Med 26, 1927.
19. Reid, IR, Mason, B, Horne, A et al. (2002) Effects of calcium supplementation on serum lipid concentrations in normal older women: a randomized controlled trial. Am J Med 112, 343347.
20. Zemel, MB, Shi, H, Greer, B et al. (2000) Regulation of adiposity by dietary calcium. FASEB J 14, 11321138.
21. Kamycheva, E, Jorde, R, Figenschau, Y et al. (2007) Insulin sensitivity in subjects with secondary hyperparathyroidism and the effect of a low serum 25-hydroxyvitamin D level on insulin sensitivity. J Endocrinol Invest 30, 126132.
22. Yin, X, Sun, Q, Zhang, X et al. (2012) Serum 25(OH)D is inversely associated with metabolic syndrome risk profile among urban middle-aged Chinese population. Nutr J 11, 68.
23. Delvin, EE, Lambert, M, Levy, E et al. (2010) Vitamin D status is modestly associated with glycemia and indicators of lipid metabolism in French-Canadian children and adolescents. J Nutr 140, 987991.
24. Husemoen, LL, Thuesen, BH, Fenger, M et al. (2012) Serum 25(OH)D and type 2 diabetes association in a general population: a prospective study. Diabetes Care 35, 16951700.
25. Choi, YJ, Kim, HC, Kim, HM et al. (2009) Prevalence and management of diabetes in Korean adults: Korea National Health and Nutrition Examination Surveys 1998–2005. Diabetes Care 32, 20162020.
26. Fraser, A, Williams, D & Lawlor, DA (2010) Associations of serum 25-hydroxyvitamin D, parathyroid hormone and calcium with cardiovascular risk factors: analysis of 3 NHANES cycles (2001–2006). PLoS One 5, e13882.
27. Liu, E, Meigs, JB, Pittas, AG et al. (2009) Plasma 25-hydroxyvitamin D is associated with markers of the insulin resistant phenotype in nondiabetic adults. J Nutr 139, 329334.
28. Del Gobbo, LC, Song, Y, Dannenbaum, DA et al. (2011) Serum 25-hydroxyvitamin D is not associated with insulin resistance or β cell function in Canadian Cree. J Nutr 141, 290295.
29. Geer, EB & Shen, W (2009) Gender differences in insulin resistance, body composition, and energy balance. Gend Med 6, Suppl. 1, 6075.
30. Lipscombe, LL & Hux, JE (2007) Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995–2005: a population-based study. Lancet 369, 750756.
31. Collaboration TERF (2010) Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 375, 22152222.
32. Forouhi, NG, Luan, J, Cooper, A et al. (2008) Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990–2000. Diabetes 57, 26192625.
33. Mattila, C, Knekt, P, Mannisto, S et al. (2007) Serum 25-hydroxyvitamin D concentration and subsequent risk of type 2 diabetes. Diabetes Care 30, 25692570.
34. Belenchia, AM, Tosh, AK, Hillman, LS et al. (2013) Correcting vitamin D insufficiency improves insulin sensitivity in obese adolescents: a randomized controlled trial. Am J Clin Nutr 97, 774781.
35. Pittas, AG, Lau, J, Hu, FB et al. (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92, 20172029.
36. Scragg, R, Sowers, M & Bell, C (2004) Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care 27, 28132818.
37. Alemzadeh, R, Kichler, J, Babar, G et al. (2008) Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism 57, 183191.
38. Manco, M, Calvani, M, Nanni, G et al. (2005) Low 25-hydroxyvitamin D does not affect insulin sensitivity in obesity after bariatric surgery. Obes Res 13, 16921700.
39. Johnson, J, Grande, J, Roche, P et al. (1994) Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol Endocrinol Metab 267, E356E360.
40. Bland, R, Markovic, D, Hills, CE et al. (2004) Expression of 25-hydroxyvitamin D3-1α-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol 89–90, 121125.
41. Maestro, B, Dávila, N, Carranza, MC et al. (2003) Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol 84, 223230.
42. Maestro, B, Molero, S, Bajo, S et al. (2002) Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D3 . Cell Biochem Funct 20, 227232.
43. Zeitz, U, Weber, K, Soegiarto, D et al. (2003) Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J 17, 509511.
44. Cade, C & Norman, AW (1986) Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo . Endocrinology 119, 8490.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed