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Predictors and consequences of anaemia among antiretroviral-naïve HIV-infected and HIV-uninfected children in Tanzania

  • Anirban Chatterjee (a1), Ronald J Bosch (a2), Roland Kupka (a3), David J Hunter (a1) (a3), Gernard I Msamanga (a4) and Wafaie W Fawzi (a1) (a3)
  • DOI: http://dx.doi.org/10.1017/S1368980009990802
  • Published online: 04 August 2009
Abstract
AbstractObjective

Predictors and consequences of childhood anaemia in settings with high HIV prevalence are not well known. The aims of the present study were to identify maternal and child predictors of anaemia among children born to HIV-infected women and to study the association between childhood anaemia and mortality.

Design

Prospective cohort study. Maternal characteristics during pregnancy and Hb measurements at 3-month intervals from birth were available for children. Information was also collected on malaria and HIV infection in the children, who were followed up for survival status until 24 months after birth.

Setting

Dar es Salaam, Tanzania.

Subjects

The study sample consisted of 829 children born to HIV-positive women.

Results

Advanced maternal clinical HIV disease (relative risk (RR) for stage ≥2 v. stage 1: 1·31, 95 % CI 1·14, 1·51) and low CD4 cell counts during pregnancy (RR for <350 cells/mm3v. ≥350 cells/mm3: 1·58, 95 % CI 1·05, 2·37) were associated with increased risk of anaemia among children. Birth weight <2500 g, preterm birth (<34 weeks), malaria parasitaemia and HIV infection in the children also increased the risk of anaemia. Fe-deficiency anaemia in children was an independent predictor of mortality in the first two years of life (hazard ratio 1·99, 95 % CI 1·06, 3·72).

Conclusions

Comprehensive care including highly active antiretroviral therapy to eligible HIV-infected women during pregnancy could reduce the burden of anaemia in children. Programmes for the prevention of mother-to-child transmission of HIV and antimalarial treatment to children could improve child survival in settings with high HIV prevalence.

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*Corresponding author: Email achatterjee24@post.harvard.edu
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1.M Ezzati , AD Lopez , A Rodgers , S Vander Hoorn & CJ Murray ; Comparative Risk Assessment Collaborating Group (2002) Selected major risk factors and global and regional burden of disease. Lancet 360, 13471360.

3.PS Belperio & DC Rhew (2004) Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: a systematic review of the literature. Am J Med 116, Suppl. 7A, 27S43S.

9.RK Chandra (1973) Reduced bactericidal activity of polymorphs in iron deficiency. Arch Dis Child 48, 864867.

11.A Mocroft , O Kirk , S Barton , M Dietrich , R Proenca , R Colebunders , C Pradier , A dArminio Monforte , B Ledergerber & JD Lundgren (1999) Anaemia is an independent predictive marker for clinical prognosis in HIV-infected patients from across Europe. EuroSIDA Study Group. AIDS 13, 943950.

12.ME O’Brien , R Kupka , GI Msamanga , E Saathoff , DJ Hunter & WW Fawzi (2005) Anemia is an independent predictor of mortality and immunologic progression of disease among women with HIV in Tanzania. J Acquir Immun Defic Syndr 40, 219225.

13.WW Fawzi , GI Msamanga , D Spiegelman (1998) Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 351, 14771482.

17.S Blanche , C Rouzioux , ML Moscato (1989) A prospective study of infants born to women seropositive for human immunodeficiency virus type 1. HIV Infection in Newborns French Collaborative Study Group. N Engl J Med 320, 16431648.

18.S Blanche , MJ Mayaux , C Rouzioux (1994) Relation of the course of HIV infection in children to the severity of the disease in their mothers at delivery. N Engl J Med 330, 308312.

19.G Lambert , DM Thea , V Pliner (1997) Effect of maternal CD4+ cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection. New York City Perinatal HIV Transmission Collaborative Study Group. J Pediatr 130, 890897.

20.EJ Abrams , J Wiener , R Carter , L Kuhn , P Palumbo , S Nesheim , F Lee , P Vink & M Bulterys ; Perinatal AIDS Collaborative Transmission Study (PACTS) Group (2003) Maternal health factors and early pediatric antiretroviral therapy influence the rate of perinatal HIV-1 disease progression in children. AIDS 17, 867877.

21.S Chearskul , T Chotpitayasunondh , RJ Simonds .; Bangkok Collaborative Perinatal HIV Transmission Study Group (2002) Survival, disease manifestation and early predictors of disease progression among children with perinatal human immunodeficiency virus infection in Thailand. Pediatrics 110, 2530.

22.A Chatterjee , RJ Bosch , DJ Hunter , MR Fataki , GI Msamanga & WW Fawzi (2007) Maternal disease stage and child undernutrition in relation to mortality among children born to HIV-infected women in Tanzania. J Acquir Immun Defic Syndr 46, 599606.

23.EM Widdowson & CM Spray (1951) Chemical development in utero. Arch Dis Child 26, 205214.

24.PN Singla , VK Gupta & KN Agarwal (1985) Storage iron in human fetal organs. Acta Pediatr Scand 74, 701706.

25.Y Burnstein , WK Rashbaum , WC Hatch , T Calvelli , M Golodner , R Soeiro & WD Lyman (1992) Alterations in human fetal erythropoiesis are associated with maternal HIV infection. Pediatr Res 32, 155159.

29.N Shaffer , K Hedberg , F Davachi , B Lyamba , JG Breman , OS Masisa , F Behets , A Hightower & P Nguyen-Dinh (1990) Trends and risk factors for HIV-1 seropositivity among outpatient children, Kinshasa, Zaire. AIDS 4, 12311236.

31.BS Eley , AA Sive , M Shuttleworth & GD Hussey (2002) A prospective, cross-sectional study of anemia and peripheral iron status in antiretroviral naïve, HIV-infected children in Cape Town, South Africa. BMC Infect Dis 2, 3.

33.RD Semba & GE Gray (2001) The pathogenesis of anemia during human immunodeficiency virus infection. J Invest Med 49, 225239.

34.TD Clark , F Mmiro , C Ndugwa , RT Perry , JB Jackson , G Melikian & RD Semba (2002) Risk factors and cumulative incidence of anaemia among human immunodeficiency virus-infected children in Uganda. Ann Trop Pediatr 22, 1117.

35.M Ellaurie , ER Burns & M Rubinstein (1990) Hematologic manifestations in pediatric HIV infection: severe anemia as a prognostic factor. Am J Pediatr Hematol Oncol 12, 449453.

36.Cross Continents Collaborative for Kids (3Cs4kids) Analysis and Writing Committee (2008) Markers for predicting mortality in untreated HIV-infected children in resource-limited settings: a meta-analysis. AIDS 22, 97105.

37.S Sazawal , RE Black , M Ramsan (2006) Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomized, placebo-controlled trial. Lancet 367, 133143.

38.JM Tielsch , SK Khatry , RJ Stotlzfus , J Katz , SC LeClerq , R Adhikari , LC Mullany , S Shresta & RE Black (2006) Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: community-based cluster-randomized, placebo-controlled trial. Lancet 367, 144152.

39.PH Pinkerton , I Spence , JC Ogilvie , WA Ronald , P Marchant & PK Ray (1970) An assessment of the Coulter counter model S. J Clin Pathol 23, 6876.

40.SN Massawe , EN Urassa , M Mmari , G Ronquist , G Lindmark & L Nystrom (1999) The complexity of pregnancy anemia in Dar-es-Salaam. Gynecol Obstet Invest 47, 7682.

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Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
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