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    Fardet, A. and Rock, E. 2014. The search for a new paradigm to study micronutrient and phytochemical bioavailability: From reductionism to holism. Medical Hypotheses, Vol. 82, Issue. 2, p. 181.


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Supplemented zinc does not alter mood in healthy older European adults – a randomised placebo-controlled trial: the Zenith study

  • Barbara J Stewart-Knox (a1), Gordon Rae (a2), Ellen EA Simpson (a2), Chris McConville (a2), Jacqueline O’Connor (a1), Angela Polito (a3), Maud Andriollo-Sanchez (a4), Charles Coudray (a5) and JJ Strain (a1)
  • DOI: http://dx.doi.org/10.1017/S1368980010002764
  • Published online: 28 January 2011
Abstract
AbstractObjective

Older people are vulnerable to zinc deficiency, which may impact upon their mood. This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans.

Subjects

Healthy volunteers (n 387) aged 55–87 years were recruited.

Setting

Volunteers in Rome (Italy; n 108) and Grenoble (France; n 91) were aged 70–87 years and those in Coleraine (Northern Ireland; n 93) and Clermont-Ferrand (France; n 95) were aged 55–70 years.

Design

Mood was measured using the Positive and Negative Affect Scale on four occasions per day over 4 d at baseline, 3 and 6 months post-intervention.

Results

Mixed ANOVA indicated that neither positive nor negative affect altered in response to zinc (15 mg/d or 30 mg/d) compared to placebo in either the 55–70 years or the ≥70 years age group.

Conclusions

These results suggest that zinc does not benefit mood in healthy older people.

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*Corresponding author: Email b.knox@ulster.ac.uk
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