Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 66
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    de Witte, Wilhelmus E.A. Danhof, Meindert van der Graaf, Piet H. and de Lange, Elizabeth C.M. 2016. In vivo Target Residence Time and Kinetic Selectivity: The Association Rate Constant as Determinant. Trends in Pharmacological Sciences,


    Buranda, Tione Swanson, Scarlett Bondu, Virginie Schaefer, Leah Maclean, James Mo, Zhenzhen Wycoff, Keith Belle, Archana and Hjelle, Brian 2014. Equilibrium and Kinetics of Sin Nombre Hantavirus Binding at DAF/CD55 Functionalized Bead Surfaces. Viruses, Vol. 6, Issue. 3, p. 1091.


    Paramanathan, Thayaparan Reeves, Daniel Friedman, Larry J. Kondev, Jane and Gelles, Jeff 2014. A general mechanism for competitor-induced dissociation of molecular complexes. Nature Communications, Vol. 5, p. 5207.


    Li, Hongjia Qing, Qing Kumar, Rajeev and Wyman, Charles E. 2013. Chromatographic determination of 1, 4-β-xylooligosaccharides of different chain lengths to follow xylan deconstruction in biomass conversion. Journal of Industrial Microbiology & Biotechnology, Vol. 40, Issue. 6, p. 551.


    Rozovsky, Sharon Forstner, Martin B. Sondermann, Holger and Groves, Jay T. 2012. Single Molecule Kinetics of ENTH Binding to Lipid Membranes. The Journal of Physical Chemistry B, Vol. 116, Issue. 17, p. 5122.


    Lee, Woo-Jin Kim, Ji-Hyun and Lee, Sang-Youb 2011. Inertial Dynamic Effect on the Rates of Diffusion-Controlled Ligand-Receptor Reactions. Bulletin of the Korean Chemical Society, Vol. 32, Issue. spc8, p. 2973.


    ElSawy, Karim M. Caves, Leo S.D. and Twarock, Reidun 2010. The Impact of Viral RNA on the Association Rates of Capsid Protein Assembly: Bacteriophage MS2 as a Case Study. Journal of Molecular Biology, Vol. 400, Issue. 4, p. 935.


    Matos, Pedro M. Franquelim, Henri G. Castanho, Miguel A.R.B. and Santos, Nuno C. 2010. Quantitative assessment of peptide–lipid interactions.. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1798, Issue. 11, p. 1999.


    Monine, Michael I. Posner, Richard G. Savage, Paul B. Faeder, James R. and Hlavacek, William S. 2010. Modeling Multivalent Ligand-Receptor Interactions with Steric Constraints on Configurations of Cell-Surface Receptor Aggregates. Biophysical Journal, Vol. 98, Issue. 1, p. 48.


    Peters, Reiner 2009. Functionalization of a nanopore: The nuclear pore complex paradigm. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol. 1793, Issue. 10, p. 1533.


    Royer, Leandro and Ríos, Eduardo 2009. Deconstructing calsequestrin. Complex buffering in the calcium store of skeletal muscle. The Journal of Physiology, Vol. 587, Issue. 13, p. 3101.


    Barisas, B. George Smith, Steven M. Liu, Jingjing Song, Jinming Hagen, Guy M. Pecht, Israel and Roess, Deborah A. 2007. Compartmentalization of the Type I Fcε receptor and MAFA on mast cell membranes. Biophysical Chemistry, Vol. 126, Issue. 1-3, p. 209.


    Goldstein, Byron Levine, Harold and Torney, David 2007. Diffusion Limited Reactions. SIAM Journal on Applied Mathematics, Vol. 67, Issue. 4, p. 1147.


    Castanho, Miguel A.R.B. and Fernandes, Miguel X. 2006. Lipid membrane-induced optimization for ligand–receptor docking: recent tools and insights for the “membrane catalysis” model. European Biophysics Journal, Vol. 35, Issue. 2, p. 92.


    Launikonis, B. S. Zhou, J. Royer, L. Shannon, T. R. Brum, G. and Rios, E. 2006. Depletion "skraps" and dynamic buffering inside the cellular calcium store. Proceedings of the National Academy of Sciences, Vol. 103, Issue. 8, p. 2982.


    Gavutis, Martynas Lata, Suman Lamken, Peter Müller, Pia and Piehler, Jacob 2005. Lateral Ligand-Receptor Interactions on Membranes Probed by Simultaneous Fluorescence-Interference Detection. Biophysical Journal, Vol. 88, Issue. 6, p. 4289.


    Lin, Shiming and Hsu, Su-Ming 2005. Recent advances in capillary electrophoretic immunoassays. Analytical Biochemistry, Vol. 341, Issue. 1, p. 1.


    Dudko, Olga K. Berezhkovskii, Alexander M. and Weiss, George H. 2004. Rate constant for diffusion-influenced ligand binding to receptors of arbitrary shape on a cell surface. The Journal of Chemical Physics, Vol. 121, Issue. 3, p. 1562.


    Hlavacek, William S. Faeder, James R. Blinov, Michael L. Perelson, Alan S. and Goldstein, Byron 2003. The complexity of complexes in signal transduction. Biotechnology and Bioengineering, Vol. 84, Issue. 7, p. 783.


    Metzger, Henry 2002. Molecular versatility of antibodies. Immunological Reviews, Vol. 185, Issue. 1, p. 186.


    ×

The biophysics of ligand–receptor interactions

  • Charles DeLisi (a1)
  • DOI: http://dx.doi.org/10.1017/S0033583500001657
  • Published online: 01 March 2009
Abstract

For the cells of an organism to act in the coordinated fashion necessary for complex functioning, they must be able to receive and transmit information. Information transfer is mediated by molecules released by the cells and may be local, as in the case of neurotransmitters, or long range, as in the case of hormones. It is apparent, however, that irrespective of the range of interaction, a cell must be able to distinguish, with a high degree of precision, the signals relevant to it from an enormous flow of background noise.

Molecular recognition at the cell surface is mediated by receptors: cell surface glycoproteins that usually form an integral part of the plasma membrane (see, for example, Cuatrecasas & Greaves, 1978). Typically, receptors bind the ligands they are designed to recognize with affinities of the order of 108 M-1, and they translate that interaction into a sequence of signals that ultimately lead to biological activity.

Copyright
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

H. C. Berg & E. M. Purcell (1977). Physics of chemoreception. Biophys. J. 20, 193219.

G. I. Bell (1978). Models for the specific adhesion of cells to cells. Science, N.Y.200, 618627.

P. Cuatrecasas & M. F. Greaves (eds.) (1978). Receptors and Recognition ser. A and B. London: Chapman and Hall.

C. DeLisi & A. Perelson (1976). The kinetics of aggregation phenomena I. Minimal models for patch formation on lymphocyte membranes. J. theor. Biol. 62, 159210.

M. Eigen (1974) In Quantum Statistical Mechanics in the Natural Sciences (ed. S. L. Minz and S. M. Wiedermayer ). New York: Plenum Press.

T. Heidman & J. P. Changeux (1978). Structural and functional properties of the acetylcholine receptor protein in its purified and membrane bound states. A. Rev. Biochem. 47, 317357.

T. L. Hill (1975). Effect of rotation on the diffusion-controlled rate of ligand-protein association. Proc. natn. Acad. Sci. U.S.A72, 49184922.

C. R. Kahn , K. L. Baird , D. B. Jarrett & J. S. Flier (1976). Direct demonstration that receptor cross-linking or aggregation is important in insulin action. Proc. natn. Acad. Sci. U.S.A.75, 42094213.

D. E. Koshland Jr (1970). The molecular basis for enzyme regulation. In The Enzymes, vol. vi (ed. D. Boyer Paul ). New York: Academic Press.

D. Lawson , C. Fewtrell , B. Gomperts & M. Raff (1975). Antiimmunoglobulin-induced histamine secretion by rat peritoneal mast cells studied by immunoferritin electron microscopy. J. exp. Med. 142, 391398.

H. Metzger (1978). The IgE mast cell system as a paradigm for the study of antibody mechanisms. Immunological Reviews 41, 186199.

A. Perelson & C. DeLisi (1980). Receptor clustering on a cell surface. I. Theory of receptor cross-links by ligands bearing two chemically identical functional groups. Math. Biosci. 48, 71110.

P. G. Saffman & M. Delbruck (1975). Brownian motion in biological membranes. Proc. natn Acad. Sci. U.S.A.72, 3111.

Y. Schechter , L. Hernaez , J. Schlessinger & P. Cuatrecasas (1979). Local aggregation of hormone receptor complexes is required for activation of epidermial growth factor. Nature, Lond.278, 835838.

J. Schlessinger , W. W. Webb , E. L. Elson & H. Metzger (1976). Lateral motion and valence of Fc receptors on rat peritoneal mast cells. Nature, Lond.264, 550.

K. S. Schmitz & J. M. Schurr (1972). The rate of orientation constraints and rotational diffusion in bimolecular solution kinetics. J. Phys. Chem. 76, 534545.

R. P. Siraganian , W. A. Hook & R. B. Levine (1975). Specific in vitro histamine release from basophils by bivalent haptens: evidence for activation by simple bridging of membrane bound antibody. Immunochem. 12, 149157.

K. Solc & W. H. Stockmayer (1971). Kinetics of diffusion-controlled reaction between chemically asymmetric molecules: General theory. J. chem. Phys. 54, 29812986.

I. Yahara & G. M. Edelman (1975). Modulation of lymphocyte receptor mobility by locally bound Con A. Proc. natn Acad. Sci. U.S.A.72, 15791583.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Quarterly Reviews of Biophysics
  • ISSN: 0033-5835
  • EISSN: 1469-8994
  • URL: /core/journals/quarterly-reviews-of-biophysics
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×