Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-24T18:12:09.379Z Has data issue: false hasContentIssue false
  • English
  • Français

DoReMi workshop on multidisciplinary approaches to evaluating cancer risks associated with low-dose internal contamination

Published online by Cambridge University Press:  21 March 2012

D. Laurier ,
I. Guseva Canu ,
S. Baatout ,
J.-M. Bertho ,
E. Blanchardon ,
S. Bouffler ,
E. Cardis ,
M. Gomolka ,
J. Hall  and
A. Kesminiene
...Show all authors
D. Laurier
Affiliation:
Institut de radioprotection et de sûreté nucléaire, IRSN, Fontenay-aux-Roses Cedex, France
I. Guseva Canu
Affiliation:
Institut de radioprotection et de sûreté nucléaire, IRSN, Fontenay-aux-Roses Cedex, France
S. Baatout
Affiliation:
Belgian Nuclear Research Centre, SCK-CEN, Mol, Belgium
J.-M. Bertho
Affiliation:
Institut de radioprotection et de sûreté nucléaire, IRSN, Fontenay-aux-Roses Cedex, France
E. Blanchardon
Affiliation:
Institut de radioprotection et de sûreté nucléaire, IRSN, Fontenay-aux-Roses Cedex, France
S. Bouffler
Affiliation:
Health Protection Agency, Centre for Radiation Chemical and Environmental Hazards, HPA-CRCE, Chilton, UK
E. Cardis
Affiliation:
Centre for Research in Environmental Epidemiology, CREAL, Barcelona, Spain
M. Gomolka
Affiliation:
Federal Office for Radiation Protection, Department of Radiation Protection and Health, BfS, Neuherberg, Germany
J. Hall
Affiliation:
Inserm U612, Institut Curie, Orsay, France
A. Kesminiene
Affiliation:
International Agency for Research on Cancer, Section of Environment and Radiation, IARC, Lyon, France
M. Kreuzer
Affiliation:
Federal Office for Radiation Protection, Department of Radiation Protection and Health, BfS, Neuherberg, Germany
E. Rage
Affiliation:
Institut de radioprotection et de sûreté nucléaire, IRSN, Fontenay-aux-Roses Cedex, France
Get access

Abstract

A workshop dedicated to cancer risks associated with low-dose internal contamination was organised in March 2011, in Paris, in the framework of the DoReMi (Low Dose Research towards Multidisciplinary Integration) European Network of Excellence. The aim was to identify the best epidemiological studies that provide an opportunity to develop a multidisciplinary approach to improve the evaluation of the cancer risk associated with internal contamination. This workshop provided an opportunity for in-depth discussions between researchers working in different fields including (but not limited to) epidemiology, dosimetry, biology and toxicology. Discussions confirmed the importance of research on the health effects of internal contamination. Several existing epidemiological studies provide a real possibility to improve the quantification of cancer risk associated with internal emitters. Areas for future multidisciplinary collaborations were identified, that should allow feasibility studies to be carried out in the near future. The goal of this paper is to present an overview of the presentations and discussions that took place during this workshop.

Keywords

Cancercontaminationinternalepidemiologydosimetryradiobiologytoxicityradiological
Type
Research Article
Information
Radioprotection , Volume 47 , Issue 1 , January 2012 , pp. 119 - 148
Copyright
© EDP Sciences, 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

AGIR (2010) Circulatory disease risk, Report of the Independent Advisory Group on Ionising Radiation. Health Protection Agency (HPA), Chilton. RCE 16: 1-116.
Akleev, A.V., Aleshchenko, A.V., Gotlib, V., Kudriashova, O.V., Semenova, L.P., Serebrianyi, A.M., et al. (2007) The adaptive response of first generation offsprings irradiated parents, Radiatsionnaia biologiia, radioecologiia / Rossiiskaia akademiia nauk 47 (5), 550-557.Google ScholarPubMed
Akleyev, A.V., Akushevich, I.V., Dimov, G.P., Veremeyeva, G.A., Varfolomeyeva, T.A., Ukraintseva, S.V., et al. (2010a) Early hematopoietic effects of chronic radiation exposure in humans, Health Phys 99 (3), 330-336.Google Scholar
Akleyev, A.V., Dimov, G.P., Varfolomeyeva, T.A. (2010b) Late effects in hemopoiesis and bone tissue among people with incorporated osteotropic isotope 90Sr, Health Phys 98 (6), 819-824.Google Scholar
Akushevich, I.V., Veremeyeva, G.A., Dimov, G.P., Ukraintseva, S.V., Arbeev, K.G., Akleyev, A.V., et al. (2011) Modeling hematopoietic system response caused by chronic exposure to ionizing radiation, Radiat Environ Biophys 50 (2), 299-311.Google ScholarPubMed
Atkinson, W.D., Law, D.V., Bromley, K.J., Inskip, H.M. (2004) Mortality of employess of the United Kingdom Atomic Energy Authority, 1946-97, Occup Environ Med 61 (7), 577-585.Google Scholar
BEIR-VI (1999) National Research Council, Committee on Health Risks of Exposure to Radon. Health effects of exposure to radon (BEIR VI), National Academy Press, Washington DC.
Bijwaard, H., Dekkers, F. (2007) Bone cancer risk of (239)pu in humans derived from animal models, Radiat Res 168 (5), 582-592.Google ScholarPubMed
Boice, J.D., Cohen, S.S., Mumma, M.T., Dupree Ellis, E.A., Eckerman, K.F., Leggett, R.W., et al. (2011) Mortality among Radiation Workers at Rocketdyne (Atomic International), 1948-2008, Radiat Res 175, 98-115.Google Scholar
Bonatera, G.A., Zügel, S., Kinscherf, R. (2010) Novel systemic cardiovascular disease biomarkers, Current Molecular Medicine 10, 180-205.Google Scholar
Cardis, E., Hatch, M. (2011) The Chernobyl accident--an epidemiological perspective, Clin Oncol (Royal College of Radiologists (Great Britain)) 23 (4), 251-260.Google Scholar
Cardis E., Pernot E. (2011) Overview of the existing epidemiological cohorts of European populations exposed to occupational, environmental or medical low dose radiations, DoReMi. Deliverable 4.1.
Carpenter, L.M., Higgins, C.D., Douglas, A.J., Maconochie, N.E., Omar, R.Z., Fraser, P., et al. (1998) Cancer mortality in relation to monitoring for radionuclide exposure in three UK nuclear industry workforces, Br J Cancer 78 (9), 1224-1232.Google Scholar
Chan, C., Hughes, T.S., Muldoon, S., Aldrich, T., Rice, C., Hornung, R., et al. (2010) Mortality patterns among Paducah Gaseous Diffusion Plant workers, J Occup Environ Med 52 (7), 725-732.Google ScholarPubMed
Darby, S., Hill, D., Deo, H., Auvinen, A., Barros-Dios, J.M., Baysson, H., et al. (2006) Residential radon and lung cancer--detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiologic studies in Europe, Scand J Work Environ Health 32 (Suppl 1), 1-83.Google Scholar
Drozdovitch, V., Khrouch, V., Maceika, E., Zvonova, I., Vlasov, O., Bratilova, A., et al. (2010) Reconstruction of radiation doses in a case-control study of thyroid cancer following the Chernobyl accident, Health Phys 99 (1), 1-16.Google Scholar
Erdmann, J., Linsel-Nitschke, , Schunkert, H. (2010) Genetic Causes of myocardial infarcation. New insights from genome-wide association studies, Dtsch. Ärztebl Int 107, 694-699.Google Scholar
Garsi, J.P., Schlumberger, M., Rubino, C., Ricard, M., Labbe, M., Ceccarelli, C., et al. (2008) Therapeutic administration of 131I for differentiated thyroid cancer: radiation dose to ovaries and outcome of pregnancies, J Nucl Med 49 (5), 845-852.Google Scholar
Guseva Canu, I., Ellis, E.D., Tirmarche, M. (2008a) Cancer risk in nuclear workers occupationally exposed to uranium-emphasis on internal exposure, Health Phys 94 (1), 1-17.Google Scholar
Guseva Canu, I., Molina, G., Goldberg, M., Collomb, P., David, J.C., Perez, P., et al. (2008b) Development of a job exposure matrix for the epidemiological follow-up of workers in the French nuclear industry, Rev Epidémiol Santé Publique 56 (1), 21-29.Google ScholarPubMed
Guseva Canu, I., Paquet, F., Goldberg, M., Auriol, B., Berard, P., Collomb, P., et al. (2009) Comparative assessing for radiological, chemical, and physical exposures at the French uranium conversion plant: Is uranium the only stressor?, Int J Hyg Environ Health 212, 398-413.Google ScholarPubMed
Guseva Canu, I., Jacob, S., Cardis, E., Wild, P., Caer-Lorho, S., Auriol, B., et al. (2010a) Reprocessed uranium exposure and lung cancer risk, Health Phys 99 (3), 308-313.Google Scholar
Guseva Canu, I., Laurier, D., Caër-Lorho, S., Samson, E., Tirmarche, M., Auriol, B., et al. (2010b) Characterisation of protracted low-level exposure to uranium in the workplace: A comparison of two approaches, Int J Hyg Environ Health 213, 270-277.Google Scholar
Guseva Canu I., Jacob S., Caer-Lorho S., Cardis E., Wild P., Garsi J.P., et al. (2011) Uranium carcinogenicity in humans might depend on the physical and chemical nature of uranium and its isotopic composition: Results from pilot epidemiological study of French nuclear workers, Cance Cause Control (in press).
Harrison, J. (2009) Biokinetic and dosimetric modelling in the estimation of radiation risks from internal emitters, J Radiol Prot. 29 (2A), A81-A105.Google ScholarPubMed
HLEG (2009) High Level and Expert Group (HLEG). HLEG Report on European Low Dose Risk Research. EUR 23884. Luxembourg, UK: Office for Official Publications of the European Communities; 2009.
Hofer, E. (2008) How to account for uncertainty due to measurement errors in an uncertainty analysis using Monte Carlo simulation, Health Phys 95 (3), 277-290.Google Scholar
Hofmann, W., Crawford-Brown, D.J., Fakir, H. and Monchaux, G. (2006) Modeling lung cancer incidence in rats following exposure to radon progeny, Radiat Prot Dosim 122 (1-4), 345-348.Google ScholarPubMed
Kesminiene A., Evrard A.-S., Ivanov V.K., Malakhova I.V., Kurtinaitis J., Stengrevics A., et al. Risk of thyroid cancer among Chernobyl liquidators., Radiat Res. (Submitted).
Kossenko, M.M., Thomas, T.L., Akleyev, A.V., Krestinina, L.Y., Startsev, N.V., Vyushkova, O.V., et al. (2005) The Techa River Cohort: study design and follow-up methods, Radiat Res 164 (5), 591-601.Google ScholarPubMed
Kreuzer, M., Schnelzer, M., Tschense, A., Walsh, L., Grosche, B. (2010) Cohort profile: the German uranium miners cohort study (WISMUT cohort), 1946-2003, Int J Epidemiol 39 (4), 980-987.Google ScholarPubMed
Kryuchkov, V., Chumak, V., Maceika, E., Anspaugh, L.R., Cardis, E., Bakhanova, E., et al. (2009) Radrue method for reconstruction of external photon doses for Chernobyl liquidators in epidemiological studies, Health Phys 97 (4), 275-298.Google ScholarPubMed
Leuraud, K., Billon, S., Bergot, D., Tirmarche, M., Caer, S., Quesne, B., et al. (2007) Lung cancer risk associated to exposure to radon and smoking in a case-control study of French uranium miners, Health Phys 92 (4), 371-378.Google Scholar
Leuraud, K., Schnelzer, M., Tomasek, L., Hunter, N., Timarche, M., Grosche, B., et al. (2011) Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners, Radiat Res 176, 375-387.Google Scholar
Little, M.P., Tawn, E.J., Tzoulaki, I., Wakeford, R., Hildebrandt, G., Paris, F., et al. (2010) Review and meta-analysis of epidemiological associations between low/moderate doses of ionizing radiation and circulatory disease risks, and their possible mechanisms, Radiat Environ Biophys, 49 (2), 139-153.Google ScholarPubMed
Marsh, J.W., Bessa, Y., Birchall, A., Blanchardon, E., Hofmann, W., Nosske, D., et al. (2008) Dosimetric models used in the Alpha-Risk project to quantify exposure of uranium miners to radon gas and its progeny, Radiat Prot Dosim 130 (1), 101-106.Google ScholarPubMed
Marsh J.W., Blanchardon E., Gregoratto D., Hofmann W., Karcher K., Nosske D., et al. (2011) Dosimetric Calculations for Uranium Miners for Epidemiological Studies, Radiat Prot Dosim (Epub ahead of print).
McGeoghegan, D., Binks, K., Gillies, M., Jones, S., Whaley, S. (2008) The non-cancer mortality experience of male workers at British Nuclear Fuels plc, 1946-2005, Int J Epidemiol 37 (3), 506-518.Google ScholarPubMed
Monchaux, G., Morlier, J.P., Altmeyer, S., Debroche, M., Morin, M. (1999) Influence of exposure rate on lung cancer induction in rats exposed to radon progeny, Radiat Res 152 (6 Suppl), S137-140.Google ScholarPubMed
Monchaux, G., Morlier, J.P., Morin, M., Chameaud, J., Lafuma, J., Masse, R. (1994) Carcinogenic and cocarcinogenic effects of radon and radon daughters in rats, Environ Health Perspect 102 (1), 64-73.Google ScholarPubMed
Ory, C., Ugolin, N., Levalois, C., Lacroix, L., Caillou, B., Bidart, J.M., et al. (2011) Gene expression signature discriminates sporadic from post-radiotherapy-induced thyroid tumors, Endocr Relat Cancer 18 (1), 193-206.Google ScholarPubMed
Ostroumova, E., Brenner, A., Oliynyk, V., McConnell, R., Robbins, J., Terekhova, G., et al. (2009) Subclinical hypothyroidism after radioiodine exposure: Ukrainian-American cohort study of thyroid cancer and other thyroid diseases after the Chornobyl accident (1998-2000), Environ Health Perspect 117 (5), 745-750.Google Scholar
Paquet F., Barbey P., Bardiès M., Biau A., Blanchardon E., Chetioui A., et al. (2011) L’évaluation et la gestion des risques associés aux expositions aux radionucléides émetteurs Auger et bêta. Avis et propositions de pistes de Recherche. Rapport IRSN/ DS 2010-03. Institut de Radioprotection et de Sûreté Nucléaire. Fontenay-aux-Roses.
Port, M., Boltze, C., Wang, Y., Roper, B., Meineke, V., Abend, M. (2007) A radiation-induced gene signature distinguishes post-Chernobyl from sporadic papillary thyroid cancers, Radiat Res 168 (6), 639-649.Google ScholarPubMed
Priest, N.D., Hoel, D. (2010) Determining the relative toxicity and RBE of internal emitters in animals, Health Phys 99 (3), 367-370.Google ScholarPubMed
Puncher, M., Birchall, A. (2008) A Monte Carlo method for calculating Bayesian uncertainties in internal dosimetry, Radiat Prot Dosim 132 (1), 1-12.Google ScholarPubMed
Rubino, C., de Vathaire, F., Dottorini, M.E., Hall, P., Schvartz, C., Couette, J.E., et al. (2003) Second primary malignancies in thyroid cancer patients, Br J Cancer 89 (9), 1638-1644.Google ScholarPubMed
Schnelzer, M., Hammer, G.P., Kreuzer, M., Tschense, A., Grosche, B. (2010) Accounting for smoking in the radon-related lung cancer risk among German uranium miners: results of a nested case-control study, Health Phys 98 (1), 20-28.Google ScholarPubMed
Sokolnikov, M.E., Gilbert, E.S., Preston, D.L., Ron, E., Shilnikova, N.S., Khokhryakov, V.V., et al. (2008) Lung, liver and bone cancer mortality in Mayak workers, Int J Cancer 123 (4), 905-911.Google ScholarPubMed
SOLO-project. SOLO: Epidemiological Studies of Exposed Southern Urals Populations. Integrated Project FP7-249675 (http://solo-fp7.eu).
SOUL-project. SOUL: Southern Urals Radiation Risk Research. Integrated Project FP6-516478 (http://www.helmholtz-muenchen.de/soul/index_new.htm).
Thierry-Chef I., Bérard P., Bingham D., Blanchardon E., Birchall A., Bull R., et al. (2010) Approach to derive doses for case-control studies of lung cancer and leukaemia among workers internally exposed to uranium and plutonium, IRPA-12.
Tirmarche M., Laurier D., Bergot D., Billon S., Brueske-Hohlfeld I., Collier C., et al. (2003) Quantification of lung cancer risk after low radon exposure and low exposure rate: synthesis from epidemiological and experimental data. Final scientific report, February 2000- July 2003. Contract FIGH-CT1999-00013. Brussels, European Commission DG XII. Euratom Research Projects and Training Activities (Volume I).
Tirmarche M., Laurier D., Bochicchio F., Cardis E., Binks K., Hofmann W., et al. (2010) Final scientific report of the Alpha Risk Project (web site: http://www.alpha-risk.org) funded by the European Commission EC FP6 (ref. FI6R-CT-2005-516483). Brussels, European Commission DG XII.
Tolstykh, E.I., Degteva, M.O., Peremyslova, L.M., Shagina, N.B., Shishkina, E.A., Krivoshchapov, V.A., et al. (2011) Reconstruction of long-lived radionuclide intakes for Techa riverside residents: strontium-90, Health Phys 101 (1), 28-47.Google ScholarPubMed
Tomasek, L. (2011) Interaction of radon and smoking among Czech uranium miners, Radiat Prot Dosim 145 (2-3), 238-242.Google ScholarPubMed
Tomasek, L., Rogel, A., Tirmarche, M., Mitton, N., Laurier, D. (2008) Lung cancer in French and Czech uranium miners: Radon-associated risk at low exposure rates and modifying effects of time since exposure and age at exposure, Radiat Res 169 (2), 125-137.Google ScholarPubMed
Tronko, M.D., Howe, G.R., Bogdanova, T.I., Bouville, A.C., Epstein, O.V., Brill, A.B., et al. (2006) A cohort study of thyroid cancer and other thyroid diseases after the Chernobyl accident: thyroid cancer in Ukraine detected during first screening, J Nat Cancer Instit 98 (13), 897-903.Google ScholarPubMed
Tuttle, R.M., Vaisman, F. andTronko, M.D. (2011) Clinical presentation and clinical outcomes in Chernobyl-related paediatric thyroid cancers: what do we know now? What can we expect in the future?, Clin Oncol (Royal College of Radiologists (Great Britain)) 23 (4), 268-275.Google ScholarPubMed
UNSCEAR (2008) United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). UNSCEAR 2006 Report to the General Assembly with Scientific Annexes, Effects of Ionizing Radiation. Vol. 1: Report and Annexes A and B New York, NY: United Nations.
UNSCEAR (2011) United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR 2008 Report, Annex D - Health effects due to radiation from the Chernobyl accident, United Nations, New York.
Vacquier, B., Caer, S., Rogel, A., Feurprier, M., Tirmarche, M., Luccioni, C., et al. (2008) Mortality risk in the French cohort of uranium miners: extended follow-up 1946-1999, Occup Environ Med 65 (9), 597-604.Google ScholarPubMed
van Dillen, T., Dekkers, F., Bijwaard, H., Kreuzer, M., Grosche, B. (2011) Lung cancer from radon: a two-stage model analysis of the WISMUT Cohort, 1955-1998, Radiat Res 175 (1), 119-130.Google ScholarPubMed
Weber, D.G., Casjens, S., Rozynek, P., Lehnert, M., Zilch-Schoneweis, S., Bryk, O., et al. (2010) Assessment of mRNA and microRNA Stabilization in Peripheral Human Blood for Multicenter Studies and Biobanks, Biomark Insights 5, 95-102.Google ScholarPubMed
Yiin, J.H., Anderson, J.L., Daniels, R.D., Seel, E.A., Fleming, D.A., Waters, K.M., et al. (2009) A nested case-control study of multiple myeloma risk and uranium exposure among workers at the Oak Ridge Gaseous Diffusion Plant, Radiat Res 171 (6), 637-645.Google ScholarPubMed
Zablotska, L.B., Ron, E., Rozhko, A.V., Hatch, M., Polyanskaya, O.N., Brenner, A.V., et al. (2010) Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident, Br J Cancer 104 (1), 181-187.Google ScholarPubMed
Zablotska, L.B., Ron, E., Rozhko, A.V., Hatch, M., Polyanskaya, O.N., Brenner, A.V., et al. (2011) Thyroid cancer risk in Belarus among children and adolescents exposed to radioiodine after the Chornobyl accident, Br J Cancer 104 (1), 181-187.Google ScholarPubMed