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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Schats, Roel and A. F. Huirne, Judith 2012. Textbook of Assisted Reproductive Techniques, Volume Two: Clinical Perspectives. p. 115.
    Huirne, Judith and Schats, Roel 2008. Textbook of Assisted Reproductive Technologies. p. 529.
    Fluker, Margo Grifo, James Leader, Arthur Levy, Michael Meldrum, David Muasher, Suheil J Rinehart, John Rosenwaks, Zev Scott, Richard T Schoolcraft, William Shapiro, Daniel B and Gordon, Keith 2001. Efficacy and safety of ganirelix acetate versus leuprolide acetate in women undergoing controlled ovarian hyperstimulation. Fertility and Sterility, Vol. 75, Issue. 1, p. 38.
    West, Christine P 1993. GnRH analogues in the treatment of fibroids. Reproductive Medicine Review, Vol. 2, Issue. 03, p. 181.
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Will GNRH antagonists be worth the wait?

  • Keith Gordon (a1) and Gary D Hodgen (a1)
Extract

Gonadotropin-releasing hormone (GnRH) is also known as luteinizing hormone-releasing hormone (LHRH), formerly luteinizing hormone releasing factor (LRF). Since this hormone regulates the secretion of both FSH and LH, we prefer to call it GnRH. GnRH antagonists, as the name implies, are a class of compounds that actively compete with GnRH for the GnRH receptor, thereby neutralizing the effects of GnRH by competitive receptor occupancy. In order to fully appreciate their potential clinical utility, it is first important to comprehend the critical role of GnRH in the regulation of the pituitary-gonadal axis and secondly to familiarize ourselves with the mechanisms of action of GnRH, GnRH agonists and GnRH antagonists.

Copyright
COPYRIGHT: © Cambridge University Press 1992
Corresponding author
Keith Gordon, The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA.
References
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Reproductive Medicine Review
  • ISSN: 0962-2799
  • EISSN: 1469-9028
  • URL: /core/journals/reproductive-medicine-review
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