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Research on ageing and longevity in Estonia

  • Riin Tamm (a1), Kai Saks (a2) and Mati Pääsuke (a3)

Due to demographic changes, the population ageing process in Estonia accelerated rapidly at the end of the 20th century. In Estonia, research in gerontology and geriatrics has no long-standing tradition. In the beginning, social aspects like the pension system, coping strategies and well-being of aged people, were the research focus. More recently, epidemiological studies of diseases seen in the older population have been extensively conducted. In clinical medicine, the main research topics have been osteoporosis, Parkinson's disease, dementia and stroke.

In this review, changes in neuromuscular function and hormonal regulation during ageing, and the genetic aspects of the Estonian Longevity Study will be described. The aim of the current paper is to introduce the main fields of gerontological research in Estonia to allow better integration with other research groups.

Corresponding author
Address for correspondence: Riin Tamm, Institute of Molecular and Cell Biology, University of Tartu, 23 Riia Street, 51010, Tartu, Estonia. Email:
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9K Saks , E Tiit , E Käärik , K Jaanson . Depressive symptoms in older Estonians: Prevalence and models. J Am Geriatr Soc 2002; 50: 1164–65.

10K Saks , H Kolk , A Soots , U Takker , M Vask . Prevalence of cardiovascular disorders among the elderly in primary care in Estonia. Scand J Prim Health Care 2003; 21: 106–9.

15P Taba , T Asser . Incidence of Parkinson's disease in Estonia. Neuroepidemiology 2003; 22: 4145.

17K Häkkinen , Pakarinen. Muscle strength and serum testosterone, cortisol and SHBG concentrations in middle-aged and elderly men and women. Acta Physiol Scand 1993; 148: 199207.

18M Pääsuke , J Ereline , H Gapeyeva , S Sirkel , P Sander . Age-related differences in twitch contractile properties of plantarflexor muscles in women. Acta Physiol Scand 2000; 170: 5157.

19M Pääsuke , J Ereline , H Gapeyeva , H Maamägi . Comparison of twitch-contractile properties of plantar-flexor muscles in young and 52- to 63-year-old men. J Aging Phys Activ 2002; 10: 160–8.

20S Kuu , H Gapeyeva , J Ereline , M Pääsuke . Twitch contractile properties of plantarflexor muscles in young and middle-aged recreationally physically active and non-active women. Aging Clin Exp Res 2009; 19: 4854.

22M Pääsuke , J Ereline , H Gapeyeva , K Joost , K Mõttus , P Taba . Leg-extension strength and chair-rise performance in elderly women with Parkinson's disease. J Aging Phys Activ 2004; 12: 511–24.

25J Jürimäe , T Jürimäe . Plasma adiponectin concentration in healthy pre- and postmenopüausal women: relationship with body composition, bone mineral, and metabolic variables. Am J Physiol Endocrinol Metab 2007; 293: E4247.

26J Jürimäe , T Kums , T Jürimäe . Plasma ghrelin concentration is a signal of decreased fat free mass in healthy elderly females. Am J Hum Biol 2009; 21: 404–6.

27J Jürimäe , T Kums , T Jürimäe . Adipocytokine and ghrelin levels in relation to bone mineral density in physically active older women: longitudinal associations. Eur J Endocrinol 2009; 160: 381–85.

30P Kapahi , BM Zid , T Harper , D Koslover , V Sapin , S Benzer . Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 2004; 14: 885–90.

31JP Phillips , TL Parkes , AJ Hilliker . Targeted neuronal gene expression and longevity in Drosophila. Exp Gerontol 2000; 35: 1157–64.

32TE Johnson , WB Wood . Genetic analysis of life-span in Caenorhabditis elegans. Proc Natl Acad Sci USA 1982; 79: 6603–7.

34M Esteller . Epigenetics in cancer. N Engl J Med 2008; 358: 1148–59.

35J Hjelmborg , I Iachine , A Skytthe Genetic influence on human lifespan and longevity. Hum Genet 2006; 119: 312–21.

36DB Hancock , ER Martin , JM Vance , WK Scott . Nitric oxide synthase genes and their interactions with environmental factors in Parkinson's disease. Neurogenetics 2008; 9: 249–62.

37AV Polonikov , VP Ivanov , MA Solodilova . Genetic variation of genes for xenobiotic-metabolizing enzymes and risk of bronchial asthma: the importance of gene–gene and gene–environment interactions for disease susceptibility. J Hum Genet 2009; 54: 440–49.

38R Hitt , Y Young-Xu , M Silver , T Perls . Centenarians: the older you get, the healthier you have been. Lancet 1999; 354: 652.

39SJ Lin , M Kaeberlein , AA Andalis Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002; 418: 344–48.

40RS Sohal , R Weindruch . Oxidative stress, caloric restriction, and aging. Science 1996; 273: 5963.

41J Marchini , LR Cardon , MS Phillips , P Donnelly . The effects of human population structure on large genetic association studies. Nat Genet 2004; 36: 512–17.

43O Lao , TT Lu , M Nothnagel Correlation between genetic and geographic structure in Europe. Curr Biol 2008; 18: 1241–48.

44M Nelis , T Esko , R Mägi Genetic structure of Europeans: a view from the North-East. PLoS One 2009; 4: e5472.

45J Novembre , T Johnson , K Bryc Genes mirror geography within Europe. Nature 2008; 456: 98101.

46BG Choi , MA McLaughlin . Why men's hearts break: cardiovascular effects of sex steroids. Endocrinol Metab Clin North Am 2007; 36: 365–77.

47K Andersen , LJ Launer , ME Dewey Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies. EURODEM Incidence Research Group. Neurology 1999; 53: 1992–97.

48R Gater , M Tansella , A Korten , BG Tiemens , VG Mavreas , MO Olatawura . Sex differences in the prevalence and detection of depressive and anxiety disorders in general health care settings: report from the World Health Organization Collaborative Study on Psychological Problems in General Health Care. Arch Gen Psychiatry 1998; 55: 405–13.

49A Aleman , RS Kahn , JP Selten . Sex differences in the risk of schizophrenia: evidence from meta-analysis. Arch Gen Psychiatry 2003; 60: 565–71.

50GF Wooten , LJ Currie , VE Bovbjerg , JK Lee , J Patrie . Are men at greater risk for Parkinson's disease than women? J Neurol Neurosurg Psychiatry 2004; 75: 637–39.

51LA Hindorff , P Sethupathy , HA Junkins . Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci USA 2009; 106: 9362–67.

52V Novelli , C Viviani Anselmi Lack of replication of genetic associations with human longevity. Biogerontology 2008; 9: 8592.

53JD Smith . Apolipoproteins and aging: emerging mechanisms. Ageing Res Rev 2002; 1: 345–65.

54CV Anselmi , A Malovini , R Roncarati Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. Rejuvenation Res 2009; 12: 95104.

55F Flachsbart , A Caliebe , R Kleindorp Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci USA 2009; 106: 2700–5.

56Y Li , WJ Wang , H Cao Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet 2009; 18: 4897–904.

57BJ Willcox , TA Donlon , Q He FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci USA 2008; 105: 13987–92.

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Reviews in Clinical Gerontology
  • ISSN: 0959-2598
  • EISSN: 1469-9036
  • URL: /core/journals/reviews-in-clinical-gerontology
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