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Peptidyl transferase activity catalyzed by protein-free 23S ribosomal RNA remains elusive

  • PHILIPP KHAITOVICH (a1), TANEL TENSON (a2), ALEXANDER S. MANKIN (a1) and RACHEL GREEN (a3)
  • Published online: 01 May 1999
Abstract

In two recent articles by Nitta et al. (1998a, 1998b), evidence was presented that in vitro-transcribed protein-free 23S rRNA of Escherichia coli (and its individual domains) can catalyze peptide bond formation. The implications of these studies are considerable because demonstration of catalytic activity associated with protein-free 23S rRNA would be fundamental to our understanding of the mechanism and evolution of protein synthesis (Noller et al., 1992; Khaitovich et al., 1999).

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Copyright
Corresponding author
Reprint requests to: Dr. Alexander S. Mankin, Center for Pharmaceutical Biotechnology—m/c 870, University of Illinois, 900 South Ashland Avenue, Chicago, Illinois 60607, USA; e-mail: shura@uic.edu.
or reprint requests to: Dr. Rachel Green, Department of Molecular Biology and Genetics, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA; email: ragreen@jhmi.edu.
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RNA
  • ISSN: 1355-8382
  • EISSN: 1469-9001
  • URL: /core/journals/rna
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