Care is an important analytical concept in social policy because of what its social organisation reveals about social formations and the nature of welfare states. To date, social policy analyses of care have focused on the social (re)organisation of care within nation states, which are largely treated as ‘sealed’ entities. Consequently these analyses neglect to examine the impact of transnational processes on the socio-organisational shifts observed. This article outlines the contours of a global political economy (GPE) of care with a view to elucidating the transnational dimensions to care restructuring. It focuses in particular on domestic care labour because of the extensive internationalisation of domestic services and its significance for the social relations of production and the division of labour. The discussion reflects on analytical issues for the academic study of social policy and care raised by a GPE approach.