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Fast oscillations in activated neocortical brain slices: an in vitro continuation of the pioneering in vivo studies of Mircea Steriade and colleagues

Published online by Cambridge University Press:  23 January 2008

Roger D. Traub ,
Mark Cunningham  and
Miles A. Whittington
Roger D. Traub*
Affiliation:
Depts of Physiology and Pharmacology, and Neurology, SUNY Downstate Medical Center, Brooklyn, NY, USA
Mark Cunningham
Affiliation:
School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle, UK
Miles A. Whittington
Affiliation:
School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle, UK
*
Correspondence shoud be addressed to: Roger D. Traub, MD, SUNY Downstate Medical Center, 450 Clarkson Ave., Box 31, Brooklyn, NY 11203U.S.A. email: roger.traub@downstate.edu
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Abstract

The seminal in vivo work of Mircea Steriade and his colleagues has, as is always the case with the most insightful and creative scientists, raised many serious questions: questions, for example, of the detailed cellular and molecular mechanisms of the phenomena they discovered. In our tribute to this great investigator, we shall present some examples, based on our in vitro and modeling work, that shed light on some of his remarkable breakthroughs: the slow oscillation of sleep (<1 Hz); the several types of fast oscillations that are superimposed on the intracellular depolarizing, or active, phases of the slow oscillation; and the transition from slow oscillation to seizure via a period of very fast (>70 Hz) oscillations.

Keywords

slow oscillationvery fast oscillationgap junctionspikeletkainate
Type
Review Article
Information
Thalamus & Related Systems , Volume 4 , Issue 1 , March 2008 , pp. 79 - 86
Copyright
Copyright © Cambridge University Press 2008

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