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The 25th anniversary of the launch of Prozac gives pause for thought: where did we go wrong?

  • Edward Shorter (a1)
Summary

The creation, in DSM-III, of the category ‘major depression’ can be linked to the launch, and success, of Prozac. The consequences of creating this broad diagnostic category are of concern in relation to the treatment of individuals with a diverse variety of depressive disorders.

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References
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1 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM-III). APA, 1980.
2 Shorter, E. Before Prozac: The Troubled History of Mood Disorders in Psychiatry. Oxford University Press, 2009.
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4 Anon. Desyrel advertisement. Am J Psychiatry 1982; 139: A518 (April).
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7 Scrip. SmithKline Beecham stresses product growth. Scrip 1993; 2 Mar: 7.
8 Wall Street Journal. National Institute for Health Care Management data see drug spending jumps 17%. Wall Street J 2002; 29 Mar: A3.
9 Shorter, E. How Everyone became Depressed: The Rise and Fall of the Nervous Breakdown. Oxford University Press, 2013.
10 Baldessarini, R. Interview. In Oral History of Neuropsychopharmacology, The First Fifty Years: Peer Interviews (Vol 5) (ed. Ban, T): 1336. ACNP, 2011.
11 American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder (5th edn) (DSM-5). APA, 2013.
12 Parker, G, Hadzi-Pavlovic, D. Melancholia: A Disorder of Movement and Mood. Cambridge University Press, 1996.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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The 25th anniversary of the launch of Prozac gives pause for thought: where did we go wrong?

  • Edward Shorter (a1)
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