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3H-Imipramine Binding to Previously Frozen Platelet Membranes from Depressed Patients, Before and After Treatment

Published online by Cambridge University Press:  02 January 2018

David Healy ,
Andreas E. Theodorou ,
Andrew M. Whitehouse ,
Kevin M. Lawrence ,
William White ,
Helen Wilton-Cox ,
Sally M. Kerry ,
Roger W. Horton  and
Eugene S. Paykel
David Healy
Affiliation:
Department of Psychiatry, University of Cambridge
Andreas E. Theodorou
Affiliation:
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London
Andrew M. Whitehouse
Affiliation:
Department of Psychiatry, University of Cambridge
Kevin M. Lawrence
Affiliation:
Research Technician, Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London
William White
Affiliation:
Department of Psychiatry, University of Cambridge
Helen Wilton-Cox
Affiliation:
Department of Psychiatry, University of Cambridge
Sally M. Kerry
Affiliation:
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London
Roger W. Horton*
Affiliation:
Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London SW17 0RE
Eugene S. Paykel
Affiliation:
Department of Psychiatry, University of Cambridge
*
∗Correspondence
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Extract

3H-imipramine binding in 39 drug-free patients with major depression and 44 healthy controls did not differ significantly between the two groups, in male or female subjects or in subgroups of depressed patients divided by endogenicity or dexamethasone suppression test result. 3H-imipramine binding in depressed patients drug-free for less than three weeks did not differ from those drug-free for longer intervals or from controls. A significant seasonal variation of 3H-imipramine Bmax was found, with lower values in summer and autumn. Treatment of depressed patients with imipramine or lofepramine for six weeks increased KD and Bmax. Methodological modification (in preparation and storage of platelets) does not explain the major differences in results between this study (using frozen platelets), a previous one (using freshly prepared platelets) and others in general, although it might contribute to the range of values reported.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 2 , August 1990 , pp. 208 - 215
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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References

Arora, R. C. & Meltzer, H. Y. (1984) Imipramine binding in subpopulations of normal human platelets. Biological Psychiatry, 19, 257–262.Google Scholar
Arora, R. C., Wunnicke, V. & Meltzer, H. Y. (1985) Effect of protein concentration on kinetic constants (kd and Bmax) of 3H-imipramine binding in blood platelets. Biological Psychiatry, 20, 116–119.CrossRefGoogle ScholarPubMed
Arora, R. C. & Meltzer, H. Y. (1988) Effects of desipramine treatment on 3H-imipramine binding in the blood platelets of depressed patients. Biological Psychiatry, 23, 397–404.CrossRefGoogle ScholarPubMed
Baron, M., Barkai, A., Gruen, R., et al (1986) Platelet [3H] imipramine binding in affective disorders: trait versus state characteristics. American Journal of Psychiatry, 143, 711–717.Google ScholarPubMed
Bech, P., Eplov, L., Gastpar, M., et al (1988) WHO pilot study on the validity of imipramine platelet receptor binding sites as a biological marker of endogenous depression. Pharmacopsychiatry, 21, 147–150.CrossRefGoogle ScholarPubMed
Braddock, L. E., Cowen, P. J., Elliott, J. M., et al (1984) Changes in the binding to platelets of [3H] imipramine and [3H] yohimbine in normal subjects taking amitriptyline. Neuropharmacology, 23, 285–286.CrossRefGoogle ScholarPubMed
Braddock, L. E., Cowen, P. J., Elliott, J. M., et al (1986) Binding of yohimbine and imipramine to platelets in depressive illness. Psychological Medicine, 16, 765–773.CrossRefGoogle ScholarPubMed
Briley, M. S., Langer, S. Z., Raisman, R., et al (1980) Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients. Science, 209, 303–305.CrossRefGoogle ScholarPubMed
Carney, M. W. P., Roth, M. & Garside, E. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 149, 659–674.CrossRefGoogle Scholar
Carstens, M. E., Engelbrecht, A. H., Russell, V. A., et al (1986) Imipramine binding sites on platelets of patients with major depressive disorder. Psychiatry Research, 18, 333–342.CrossRefGoogle ScholarPubMed
Corash, L. (1980) Platelet heterogeneity; relevance to the use of platelets to study psychiatric disorders. Schizophrenia Bulletin, 6, 254–258.CrossRefGoogle Scholar
Cowen, P. J., Geany, D. P., Schachter, M., et al (1986). Desipramine treatment in normal subjects. Effects on neuroendocrine responses to tryptophan and on platelet serotonin (5–HT)-related receptors. Archives of General Psychiatry, 43, 61–67.CrossRefGoogle ScholarPubMed
Egrise, D., Rubinstein, M., Schoutens, A., et al (1986) Seasonal variation of platelet serotonin uptake and 3H-imipramine binding in normal and depressed subjects. Biological Psychiatry, 21, 283–292.CrossRefGoogle ScholarPubMed
Galzin, A-M., Loo, H., Sechter, D., et al (1986) Lack of seasonal variation in platelet [3H] imipramine binding in humans. Biological Psychiatry, 21, 876–882.CrossRefGoogle ScholarPubMed
Gentsch, C., Lichtsteiner, M., Gaspar, M., et al (1985) 3H-imipramine binding sites in platelets of hospitalised psychiatric patients. Psychiatry Research, 14, 177–187.CrossRefGoogle Scholar
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–296.CrossRefGoogle ScholarPubMed
Healy, D., Whitehouse, A. M., White, W., et al (1990) Platelet α2-adrenoceptor and 3H-imipramine binding during desipramine administration and withdrawal in healthy volunteers. Neuropsychopharmacology (in press).Google Scholar
Hrdina, P. D., Lapierre, Y. D., Horn, E. R., et al (1985) Platelet 3H imipramine binding: a possible predictor of response to antidepressant treatment. Progress in Neuropsychopharmacology and Biological Psychiatry, 9, 619–623.CrossRefGoogle Scholar
Innis, R. B., Charney, D. S. & Heninger, G. R. (1987) Differential 3H-imipramine platelet binding in patients with panic disorder and depression. Psychiatry Research, 21, 33–41.CrossRefGoogle ScholarPubMed
Kanof, P. D., Coccaro, E. F., Johns, C. A., et al (1987) Platelet [3H] imipramine binding in psychiatric disorders. Biological Psychiatry, 22, 278–286.CrossRefGoogle ScholarPubMed
Lancer, S. Z., Zarifian, E., Briley, M., et al (1982) High-affinity 3H-imipramine binding: a new biological marker in depression. Pharmacopsychiatry, 15, 4–10.Google Scholar
Lewis, D. A. & McChesney, C. (1985) Tritiated imipramine binding distinguishes amongst subtypes of depression. Archives of General Psychiatry, 42, 485–488.CrossRefGoogle Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L., et al (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry, 193, 265–275.CrossRefGoogle ScholarPubMed
Maj, M., Mastronardi, P., Cerreta, A., et al (1988) Changes in platelet 33H-imipramine binding in depressed patients receiving electroconvulsive therapy. Biological Psychiatry, 24, 469–472.CrossRefGoogle ScholarPubMed
Mellerup, E. T., Plenge, P. & Rosenberg, R. (1982) 3H-imipramine binding sites in platelets from psychiatric patients. Psychiatry Research, 7, 221–227.CrossRefGoogle ScholarPubMed
Mellerup, E. T. & Plenge, P. (1988) Imipramine binding in depression and other psychiatric disorders. Acta Psychiatrica Scandinavica, 78 (suppl. 345), 61–68.CrossRefGoogle Scholar
Nemeroff, C. B., Knight, D. L., Krishnan, R. R., et al (1988) Marked reduction in the number of platelet-tritiated imipramine binding sites in geriatric depression. Archives of General Psychiatry, 45, 919–923.CrossRefGoogle ScholarPubMed
Paul, S. M., Rehavi, M., Skolnick, P., et al (1981) Depressed patients have decreased binding of tritiated imipramine to platelet serotonin “transporter”. Archives of General Psychiatry, 38, 1315–1317.CrossRefGoogle ScholarPubMed
Paykel, E. S. (1985) The clinical interview for depression. Development, reliability and validity. Journal of Affective Disorders, 9, 85–96.CrossRefGoogle ScholarPubMed
Plenge, P., Mellerup, E. T. & Gjerris, A. (1988) Imipramine binding in depressed patients diagnosed according to different criteria. Acta Psychiatrica Scandinavica, 78, 156–161.CrossRefGoogle ScholarPubMed
Poirier, M-F., Benkelfat, C., Loo, H., et al (1986) Reduced Bmax of [3H]-imipramine binding to platelets of depressed patients free of previous medication with 5HT uptake inhibitors. Psychopharmacology, 89, 456–461.CrossRefGoogle ScholarPubMed
Poirier, M-F., Galzin, A-M., Loo, H., et al (1987) Changes in [3H]5–HT uptake and [3H] imipramine binding in platelets after chlorimipramine in healthy volunteers. Comparison with maprotiline and amineptine. Biological Psychiatry, 22, 287–302.CrossRefGoogle ScholarPubMed
Raisman, R., Sechter, D., Briley, M. S., et al (1981) High-affinity 3H-imipramine binding in platelets from untreated and treated depressed patients compared to healthy volunteers. Psychopharmacology, 75, 368–371.CrossRefGoogle ScholarPubMed
Raisman, R., Briley, M. S., Bouchami, F., et al (1982) 3H-Imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers. Psychopharmacology, 77, 332–335.CrossRefGoogle ScholarPubMed
Roy, A., Everett, D., Pickar, D., et al (1987) Platelet tritiated imipramine binding and serotonin uptake in depressed patients and controls. Relationship to plasma Cortisol levels before and after dexamethasone administration. Archives of General Psychiatry, 44, 320–327.CrossRefGoogle ScholarPubMed
Statistical Analytical Systems (1982) SAS User's Guide: Basic Statistics. Cary, USA: SAS Institute Inc.Google Scholar
Schneider, L. S., Fredrickson, E. R., Severson, J. A., et al (1986) 3H-Imipramine binding in depressed elderly: relationship to family history and clinical response. Psychiatry Research, 19, 257–266.CrossRefGoogle ScholarPubMed
Spitzer, R. L. & Endicott, J. (1978) Research Diagnostic Criteria for a Selected Group of Functional Disorders (3rd edn). New York: New York Psychiatric Institute.Google Scholar
Suranyi-Cadotte, B. E., Lafaille, F., Schwartz, G., et al (1985) Unchanged platelet 3H-imipramine binding in normal subjects after imipramine administration. Biological Psychiatry, 20, 1237–1240.CrossRefGoogle ScholarPubMed
Theodorou, A. E., Katona, C. L. E., Davies, S. L., et al (1989) 3H-Imipramine binding to freshly prepared platelet membranes in depression. Psychiatry Research, 29, 87–103.CrossRefGoogle ScholarPubMed
Wagner, A., Abero-Wistedt, A., Asberg, M., et al (1985) Lower 3H-imipramine binding in platelets from untreated depressed patients compared to healthy controls. Psychiatry Research, 16, 131–139.CrossRefGoogle ScholarPubMed
Wagner, A., Abero-Wistedt, A., Asberg, M., et al (1987) Effects of antidepressant treatments on platelet tritiated imipramine binding in major depressive disorder. Archives of General Psychiatry, 44, 870–877.CrossRefGoogle ScholarPubMed
Whitaker, P. M., Warsh, J. J., Stacer, H. C., et al (1984) Seasonal variation in platelet 3H-imipramine binding: comparable values in control and depressed populations. Psychiatry Research, 11, 127–131.CrossRefGoogle ScholarPubMed
World Health Organization (1977) The International Classification of Diseases (9th edn). Geneva: WHO.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. S. (1974) Measurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press Google Scholar
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