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Abnormal Intestinal Permeability

An Aetiological Factor in Chronic Psychiatric Disorders?

Published online by Cambridge University Press:  02 January 2018

N. C. Wood ,
I. Hamilton ,
A. T. R. Axon ,
S. A. Khan ,
P. Quirke ,
R. H. S. Mindham  and
K. McGuigan
N. C. Wood
Affiliation:
Stratford upon Avon
I. Hamilton
Affiliation:
The General Infirmary, Leeds
A. T. R. Axon*
Affiliation:
The General Infirmary, Leeds
S. A. Khan
Affiliation:
High Royds Hospitals, Menston; Department of Psychiatry & Behavioural Medicine, Peoria, Illinois, 616014, USA
P. Quirke
Affiliation:
University of Leeds
R. H. S. Mindham
Affiliation:
University of Leeds
K. McGuigan
Affiliation:
H.M. Prison, Grendon Underwood, Aylesbury
*
The Gastroenterology Unit, The General Infirmary, Leeds LS1 3EX
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Abstract

Abnormal intestinal absorption has been suggested as an aetiological factor in schizophrenia. A procedure for investigating intestinal permeability was carried out in a group of chronic psychiatric in-patients. A proportion of the subjects studied showed abnormal intestinal permeability which could not be attributed to established bowel disease. Patients who were receiving neuroleptic but not anticholinergic drugs were those most often showing abnormal intestinal permeability. This work is at an early stage of development but preliminary findings suggest that further investigations should be carried out to establish the circumstances in which changes in intestinal permeability may be associated with mental illness.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 150 , Issue 6 , June 1987 , pp. 853 - 856
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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References

Cobden, I., Rothwell, J. & Axon, A. T. R. (1980) Intestinal permeability and screening tests for coeliac disease. Gut, 21, 512–518.Google Scholar
Cobden, I., Hamilton, I., Rothwell, J. & Axon, A. T. R. (1985) The cellobiose/mannitol test: physiological properties of probe molecules and influence of extraneous factors. Clinical Chimica Acta, 148, 53–62.Google Scholar
Dohan, F. L. (1970) Coeliac disease and schizophrenia. In The Lancet, 1, 897–898.Google Scholar
Dohan, F. & Grasberger, J. L. (1973) Relapsed schizophrenics; earlier discharge from hospital after cereal-free and milk-free diet. American Journal of Psychiatry, 130, 685–688.Google Scholar
Feighner, J. P., Robins, E., Guze, S. R. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.Google Scholar
Hamilton, I., Cobden, I., Rothwell, J. & Axon, A. T. R. (1982) Intestinal permeability in coeliac disease. The response to treatment and single dose gluten challenge. Gut, 23, 202–210.Google Scholar
Hekkens, WTh. J. M., Schipperijn, A. J. M. & Freed, D. L. J. (1980) Antibodies to wheat proteins in schizophrenia: relationship or coincidence? Biochemistry of Schizophrenia and Addiction, ed. Hemmings, G. Lancaster, MTP Press.Google Scholar
Ktvel, R. M., Kearns, D. H. & Liebowitz, D. (1964) Significance of antibodies to dietary proteins in the sera of patients with nontropical sprue. New England Journal of Medicine, 271, 761–772.Google Scholar
Lancet, (1983) Gluten in schizophrenia. The Lancet, i, 744–745.Google Scholar
Singh, M. M., Kay, S. R. (1976) Wheat gluten as a pathogenic factor in schizophrenia. Science, 191, 190–191.Google Scholar
Storms, L. H., Clopton, J. M., Wright, C. (1982) Effects of gluten on schizophrenics. Archives of General Psychiatry, 39, 323–327.Google Scholar
Sugarman, A. A., Southern, D. L., Curran, J. E. (1982) A study of antibody levels in alcoholic, depressive and schizophrenic patients. Annals of Allergy, 48, 166–171.Google Scholar
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