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A Controlled Trial of L-Tryptophan in Mania

Published online by Cambridge University Press:  29 January 2018

C. A. Chambers
Royal Dundee Liff Hospital, By Dundee
G. J. Naylor
Department of Psychiatry, The University, Dundee


A double-blind placebo-controlled trial of L-tryptophan, with pyridoxine and ascorbic acid, was carried out in 10 female patients suffering from mania.

In contrast to earlier studies led by Prange and Murphy, L-tryptophan was found to be no better than placebo.

Copyright © Royal College of Psychiatrists, 1978 

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