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MDMA-assisted psychotherapy in major depression: critical considerations for clinical translation: commentary, Kvam et al

Published online by Cambridge University Press:  06 March 2026

Tor-Morten Kvam Open the ORCID record for Tor-Morten Kvam [Opens in a new window] ,
Ivar Walderhaug Goksøyr ,
Justyna Rog ,
Ingrid Autran ,
Mark Berthold-Losleben  and
Ole Andreas Andreassen Open the ORCID record for Ole Andreas Andreassen [Opens in a new window]
Tor-Morten Kvam*
Affiliation:
DPS Nord, Østfold Hospital Trust, Grålum, Norway Institute of Clinical Medicine, University of Oslo, Norway
Ivar Walderhaug Goksøyr
Affiliation:
DPS Nord, Østfold Hospital Trust, Grålum, Norway
Justyna Rog
Affiliation:
DPS Nord, Østfold Hospital Trust, Grålum, Norway
Ingrid Autran
Affiliation:
DPS Nord, Østfold Hospital Trust, Grålum, Norway
Mark Berthold-Losleben
Affiliation:
DPS Nord, Østfold Hospital Trust, Grålum, Norway Department of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway
Ole Andreas Andreassen
Affiliation:
Institute of Clinical Medicine, University of Oslo, Norway Centre for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Norway
*
Correspondence: Tor-Morten Kvam. Email: tor-morten.kvam@so-hf.no
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Abstract

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Keywords

Depressive disordersclinical trialspsychological medicinepsychotherapypsychopharmacology

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Type
Commentary
Information
The British Journal of Psychiatry , First View , pp. 1 - 2
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Copyright
© The Author(s), 2026. Published by Cambridge University Press on behalf of Royal College of Psychiatrists

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References

Ai, Y, Xie, J, Hou, X. MDMA-assisted psychotherapy in major depression: critical considerations for clinical translation: commentary, Ai et al. Br J Psychiatry [Epub ahead of print] 10 Dec 2025. Available from: https://doi.org/10.1192/bjp.2025.10474.Google ScholarPubMed
European Medicines Agency. ICH Topic E 9 Statistical Principles for Clinical Trials . European Medicines Agency, 1998 (www.ema.europa.eu).Google Scholar
Kvam, T-M, Goksøyr, IW, Stewart, LH, Repantis, D, Røssberg, JI, Andreassen, OA. Study protocol for ‘MDMA-assisted therapy as a treatment for major depressive disorder: a proof of principle study’. Front Psychiatry 2022; 13: 954388.10.3389/fpsyt.2022.954388CrossRefGoogle ScholarPubMed
Kvam, TM, Goksoyr, IW, Rog, J, van de Vooren, IJ, Stewart, LH, Autran, I, et al. MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study. Br J Psychiatry 2025; 227: 1–7.10.1192/bjp.2025.10320CrossRefGoogle ScholarPubMed
Johnson, M, Richards, W, Griffiths, R. Human hallucinogen research: guidelines for safety. J Psychopharmacol 2008; 22: 603–20.10.1177/0269881108093587CrossRefGoogle ScholarPubMed

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