1
Thapar, A, Rutter, M. Do prenatal risk factors cause psychiatric disorder? Be wary of causal claims. Br J Psychiatry
2009; 195: 100–1.
2
Pawlby, S, Hay, DF, Sharp, D, Waters, CS, O'Keane, V. Antenatal depression predicts depression in adolescent offspring: prospective longitudinal community based study. J Affect Disord
2009; 113: 236–43.
3
Hay, DF, Pawlby, S, Waters, CS, Perra, O, Sharp, D. Mothers' antenatal depression and their children's antisocial outcomes. Child Dev
2010; 81: 149–65.
4
O'Connor, TG, Heron, J, Golding, J, Beveridge, M, Glover, V. Maternal antenatal anxiety and children's behavioural/emotional problems at 4 years. Report from the Avon Longitudinal Study of Parents and Children. Br J Psychiatry
2002; 180: 502–8.
5
Oates, MR. Adverse effects of maternal antenatal anxiety on children: causal effect or developmental continuum?
Br J Psychiatry
2002; 180: 478–9.
6
Bifulco, A, Moran, PM, Baines, R, Bunn, A, Stanford, K. Exploring psychological abuse in childhood: II. Association with other abuse and adult clinical depression. Bull Menninger Clin
2002; 66: 241–58.
7
Cicchetti, D, Toth, S. A developmental psychopathology perspective on child abuse and neglect. J Am Acad Child Adolesc Psychiatry
1995; 34: 541–65.
8
Widom, SP, DuMont, K, Czaia, SJ. A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Arch Gen Psychiatry
2007; 64: 49–56.
9
Danese, A, Moffitt, TE, Pariante, CM, Ambler, A, Poulton, R, Caspi, A. Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry
2008; 65: 409–15.
10
Zhou, Y, Hallisey, EJ, Freymann, GR. Identifying perinatal risk factors for infant maltreatment: an ecological approach. Int J Health Geographics
2006; 5: 53–64.
11
Sharp, DJ, Hay, DF, Pawlby, SJ, Schmücker, G, Allen, H, Kumar, R. The impact of postnatal depression on boys' intellectual development. J Child Psychol Psychiatry
1995; 36: 1315–36.
12
Goldberg, D, Cooper, B, Eastwood, MT, Kedward, HB, Shepherd, M. A standardised psychiatric interview for use in community surveys. Br J Prev Soc Med
1970; 24: 18–23.
13
Spitzer, RL, Endicott, J, Robbins, E. The Schedule for Affective Disorders and Schizophrenia – Lifetime version (SADS-L) 3rd Edn. Biometric Research, 1978.
14
Angold, A, Prendergast, M, Cox, A, Harrington, R, Simonoff, E, Rutter, M. The Child and Adolescent Psychiatric Assessment (CAPA). Psychol Med
1995; 25: 739–53.
15
Angold, A, Erkanli, A, Costello, EJ, Rutter, M. Precision, reliability and accuracy in the dating of symptom onsets in child and adolescent psychopathology. J Child Psychol Psychiatry
1996; 37: 657–64.
16
Angold, A, Costello, EJ. The Child and Adolescent Psychiatric Assessment (CAPA). J Am Acad Child Adolesc Psychiatry
2000; 39: 39–48.
17
Goodman, R, Meltzer, H, Bailey, V. The strengths and difficulties questionnaire: A pilot study on the validity of the self-report version. Eur Child Adolesc Psychiatry
1998; 7: 125–30.
18
Hay, DF, Pawlby, S, Waters, CS, Sharp, D. Antepartum and postpartum exposure to maternal depression: Different effects on different adolescent outcomes. J Child Psychol Psychiatry
2008; 49: 1079–88.
19
National Research Council, Commission on Behavioral and Social Sciences and Education. Understanding Child Abuse and Neglect. National Academy Press, 1993.
20
Kaplan, SJ, Sunday, SR, Labruna, V, Pelcovitz, D, Salzinger, S. Psychiatric disorders of parents of physically abused adolescents. Fam Viol
2009; 24: 273–81.
21
Oliver, JE. Successive generations of child maltreatment: social and medical disorders in the parents. Br J Psychiatry
1985; 147: 484–90.
22
Misri, S, Kendrick, K. Perinatal depression, fetal bonding, and mother-child attachment: a review of the literature. Curr Pediatr Rev
2008; 4: 66–70.
23
Pariante, CM, Seneviratne, G, Howard, L. Should we stop using tricyclic antidepressants in pregnancy?
Psychol Med
2011; 41: 15–7.
25
Champagne, FA, Meaney, MJ. Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model. Biol Psychiatry
2006; 59: 1227–35.
26
O'Keane, V, Lightman, S, Marsh, M, Pawlby, S, Papadopoulos, AS, Taylor, A, et al. Increased pituitary-adrenal activation and shortened gestation in a sample of depressed pregnant women: a pilot study. J Affect Disord
2010; 130: 300–5.
27
Feldman, R, Weller, A, Zagoory-Sharon, O, Levine, A. Evidence for a neuroendocrinological foundation of human affiliation: plasma oxytocin levels across pregnancy and the postpartum period predict mother-infant bonding. Psychol Sci
2007; 18: 965–70.
28
Pariante, CM, Lightman, SL. The HPA axis in major depression: classical theories and new developments. Trends Neurosci
2008; 31: 464–8.
29
Kashani, J, Shekim, W, Burk, J, Beck, N. Abuse as a predictor of psychopathology in children and adolescents. J Clin Child Psychol
1987; 16: 43–50.
30
Famularo, RMD, Kinscherff, R, Fenton, T. Psychiatric diagnoses of maltreated children: Preliminary findings. J Am Acad Child Adolesc Psychiatry
1992; 31: 863–7.
31
Danese, A, Caspi, A, Williams, B, Ambler, A, Sugden, K, Mika, J, et al. Biological embedding of stress through inflammation processes in childhood. Mol Psychiatry
2011; 16: 244–6.
32
Shin, SH, Hong, HG, Hazen, AL. Childhood sexual abuse and adolescent substance use: a latent class analysis. Drug Alcohol Depend
2010; 109: 226–35.
33
Fergusson, DM, Horwood, LJ, Lynskey, MT. Childhood sexual abuse, adolescent sexual behaviors and sexual revictimization. Child Abuse Negl
1997; 21: 789–803.
34
Kaufman, J, Birmaher, B, Brent, D, Dahl, R, Bridge, J, Ryan, ND. Psychopathology in the relatives of depressed-abused children. Child Abuse Negl
1998; 22: 171–81.
35
De Bellis, MD, Broussard, ER, Herring, DJ, Wexler, S, Moritz, G, Benitez, JG. Psychiatric co-morbidity in caregivers and children involved in maltreatment: a pilot research study with policy implications. Child Abuse Negl
2001; 25: 923–44.
36
Chambers, C. Selective serotonin reuptake inhibitors and congenital malformations. BMJ
2009; 339: b3525.
37
Heim, C, Newport, DJ, Mletzko, T, Miller, AH, Nemeroff, CB. The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology
2008; 33: 693–710.
38
Danese, A, Pariante, CM, Caspi, A, Taylor, A, Poulton, R. Childhood maltreatment predicts adult inflammation in life-course study. Proc Natl Acad Sci USA
2007; 104: 1319–24.
39
Hart, J, Gunnar, M, Cicchetti, D. Salivary cortisol in maltreated children: evidence of relations between neuroendocrine activity and social competence. Dev Psychopathol
1995; 7: 11–26.
40
Glover, V, O'Connor, TG, O'Donnell, K. Prenatal stress and the programming of the HPA axis. Neurosci Biobehav Rev
2010; 35: 17–22.
41
Goldthorpe, JH, Hope, K. The Social Grading of Occupations: A New Approach and Scale. Oxford University Press, 1974.
Manjeet S. Bhatia
21 October 2011
The article by Susan Pawlby et al is an excellent one and gives new insight into many aspects of antenatal depression and offspring psychopathology. It is a prospective study and longitudinally covers many areas of antenatal depression, childhood maltreatment and subsequent psychopathology.There are. however some limitations. Firstly, there must have been a longitudinal control of subjects having depression but not associated with pregnancy and also a group of pregnant subjects without depression and then effects on childhood psychopathology, and also a control group of children facing antenatal depression but having no psychopathology. Secondly, maternal depression was first assessed at36 weeks of pregnancy and not earlier (because there may be change in severity of depression in every trimester)and then assessment was done at 3 months after delivery (as many cases of antenatal depression and postpartum depression may subside in this period)and then at 12 months postpartum ( which is longer than average duration of postpartum depression).Thirdly, children's experience of maltreatment was taken in preceding 3 months prior to interview at 11 years only. Fourthly, the reason of assessment of maternal history of childhood physical and/or sexual abuse 4 years after birth of offspring not mentioned. Fifthly, the details of rating scale for emotional security would have been more informative. Sixthly, many variables e.g. biological parent versus step parent, only parent/parent living without spouse, inclusion of both parents in study, antenatal depression as a mediator or moderator,effects of antenatal depression on different sibling order, factors associated with continuation of antenatal depression in postpartum period would have been more informative. This study however stresses many important points regarding treatment of depression in antenatal period and need of future studies about continuity of antenatal, perinatal and postnatal depression and its impact on offspring psychopathology. ... More
Conflict of interest: None declared
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