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Antipsychotic Drug-Induced Dysphoria

  • D. J. King (a1), M. Burke (a2) and R. A. Lucas (a3)
Abstract
Background

Dysphoric reactions to antipsychotic medication are well recognised in association with akathisia, but can also occur independently.

Method

Fifty-one healthy volunteers were given haloperidol 5 mg in two consecutive pharmacokinetic studies.

Results

Dysphoria occurred in about 40% of the subjects on both occasions, but akathisia was only detected in 8% (first study) and 16% (second study). All adverse effects were transient and were abolished in nine of the ten subjects given procyclidine.

Conclusions

While dysphoria is a well-recognised reaction in healthy volunteers, it is probably insufficiently recognised in patients, particularly if it occurs in the absence of akathisia. Better detection could improve compliance in patients.

Copyright
Corresponding author
Dr King, Department of Therapeutics and Pharmacology, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL
References
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Antipsychotic Drug-Induced Dysphoria

  • D. J. King (a1), M. Burke (a2) and R. A. Lucas (a3)
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