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Aripiprazole in the treatment of the psychosis prodrome: An open-label pilot study

  • Scott W. Woods (a1), Elizabeth M. Tully (a1), Barbara C. Walsh (a1), Keith A. Hawkins (a1), Jennifer L. Callahan (a1), Shuki J. Cohen (a1), Daniel H. Mathalon (a1), Tandy J. Miller (a2) and Thomas H. McGlashan (a1)...
Abstract
Background

Research studies for the treatment of the putative prodromal phase of psychotic disorders have begun to appear

Aims

To obtain preliminary evidence of the short-term efficacy and safety of aripiprazole treatment in people with the psychosis prodrome

Method

Fifteen participants meeting prodrome criteria (mean age 17.1 years, s.d.=5.5) enrolled in an open-label, single-site trial with fixed-flexible dosing of aripiprazole (5–30 mg/day) for 8 weeks

Results

In the mixed-effects repeated-measures analysis, improvement from baseline on the Scale of Prodromal Symptoms total score was statistically significant by the first week. No participant converted to psychosis and 13 completed treatment. Neuropsychological measures showed no consistent improvement; mean weight gain was 1.2 kg. Akathisia emerged in 8 participants, but the mean Barnes Akathisia Scale score fell to baseline levels by the final visit. Adverse events were otherwise minimal

Conclusions

Aripiprazole shows a promising efficacy and safety profile for the psychosis prodrome. Placebo-controlled studies are indicated

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Copyright
Corresponding author
Dr Scott Woods, 34 Park Street, New Haven, CT 06519, USA. Email: scott.woods@yale.edu
Footnotes
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Declaration of interest

S.W.W. has received grants from Bristol-Myers Squibb, Janssen, and Eli Lilly.

Footnotes
References
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Aripiprazole in the treatment of the psychosis prodrome: An open-label pilot study

  • Scott W. Woods (a1), Elizabeth M. Tully (a1), Barbara C. Walsh (a1), Keith A. Hawkins (a1), Jennifer L. Callahan (a1), Shuki J. Cohen (a1), Daniel H. Mathalon (a1), Tandy J. Miller (a2) and Thomas H. McGlashan (a1)...
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