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Bipolar depression and treatment with antidepressants

  • Guy M. Goodwin (a1)

Summary

Treatment of bipolar disorder with antidepressants tested almost exclusively in unipolar cases is common but unsupported by an appropriate body of evidence. This anomaly is highlighted by a large Taiwanese study, which implies that patients with depression difficult to treat with antidepressants are quite likely to be diagnosed subsequently with bipolar disorder.

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References

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1 Angst, J. The bipolar spectrum. Br J Psychiatry 2007; 190: 189–91.
2 Angst, J, Cui, L, Swendsen, J, Rothen, S, Cravchik, A, Kessler, RC, et al. Major depressive disorder with subthreshold bipolarity in the National Comorbidity Survey Replication. Am J Psychiatry 2010; 167: 1194–201.
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5 Sachs, GS, Nierenberg, AA, Calabrese, JR, Marangell, LB, Wisniewski, SR, Gyulai, L, et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med 2007; 356: 1711–22.
6 Goodwin, GM. Evidence-based guidelines for treating bipolar disorder: revised second edition – recommendations from the British Association for Psychopharmacology. J Psychopharmacol 2009; 23: 346–88.
7 Li, C-T, Bai, Y-M, Huang, Y-L, Chen, Y-S, Chen, T-J, Cheng, J-Y, et al. Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study. Br J Psychiatry 2012; 200: 4551.
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Bipolar depression and treatment with antidepressants

  • Guy M. Goodwin (a1)

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Bipolar depression and treatment with antidepressants

  • Guy M. Goodwin (a1)
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