Xie, Yijun Huang, Di Wei, Li and Luo, Xiong-Jian 2018. Further evidence for the genetic association between CACNA1I and schizophrenia. Hereditas, Vol. 155, Issue. 1,
He, Kuanjun Guo, Chuang He, Lin and Shi, Yongyong 2018. MiRNAs of peripheral blood as the biomarker of schizophrenia. Hereditas, Vol. 155, Issue. 1,
Liu, Jie Zhang, Hong-Xin Li, Zhi-Qiang Li, Tao Li, Jun-Yan Wang, Ti Li, You Feng, Guo-Yin Shi, Yong-Yong and He, Lin 2017. The YWHAE gene confers risk to major depressive disorder in the male group of Chinese Han population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 77, p. 172.
Cui, Xuelian Niu, Wei Kong, Lingming He, Mingjun Jiang, Kunhong Chen, Shengdong Zhong, Aifang Li, Wanshuai Lu, Jim and Zhang, Liyi 2017. Long noncoding RNA expression in peripheral blood mononuclear cells and suicide risk in Chinese patients with major depressive disorder. Brain and Behavior, Vol. 7, Issue. 6, p. e00711.
Cui, Xuelian Niu, Wei Kong, Lingming He, Mingjun Jiang, Kunhong Chen, Shengdong Zhong, Aifang Li, Wanshuai Lu, Jim and Zhang, Liyi 2017. Can lncRNAs be indicators for the diagnosis of early onset or acute schizophrenia and distinguish major depressive disorder and generalized anxiety disorder?-A cross validation analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 174, Issue. 4, p. 335.
Yue, Weihua Yu, Xin and Zhang, Dai 2017. Progress in genome-wide association studies of schizophrenia in Han Chinese populations. npj Schizophrenia, Vol. 3, Issue. 1,
Zhang, Sheng-Yu Hu, Qiang Tang, Tao Liu, Chao Li, Cheng-Chong Yang, Xiao-Guang Zang, Yin-Yin and Cai, Wei-Xiong 2017. Role of CACNA1C gene polymorphisms and protein expressions in the pathogenesis of schizophrenia: a case-control study in a Chinese population. Neurological Sciences, Vol. 38, Issue. 8, p. 1393.
Ou, Jianjun Li, Ming and Xiao, Xiao 2017. The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders. The World Journal of Biological Psychiatry, Vol. 18, Issue. 7, p. 557.
Cariaga-Martinez, Ariel and Alelú-Paz, Raúl 2017. Rethinking the Epigenetic Framework to Unravel the Molecular Pathology of Schizophrenia. International Journal of Molecular Sciences, Vol. 18, Issue. 12, p. 790.
Mallas, E. Carletti, F. Chaddock, C. A. Shergill, S. Woolley, J. Picchioni, M. M. McDonald, C. Toulopoulou, T. Kravariti, E. Kalidindi, S. Bramon, E. Murray, R. Barker, G. J. and Prata, D. P. 2017. The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder1. Genes, Brain and Behavior, Vol. 16, Issue. 4, p. 479.
Cui, Xuelian Niu, Wei Kong, Lingming He, Mingjun Jiang, Kunhong Chen, Shengdong Zhong, Aifang Zhang, Qiaoli Li, Wanshuai Lu, Jim and Zhang, Liyi 2017. Long noncoding RNA as an indicator differentiating schizophrenia from major depressive disorder and generalized anxiety disorder in nonpsychiatric hospital. Biomarkers in Medicine, Vol. 11, Issue. 3, p. 221.
Khan, Raja Amjad Waheed Chen, Jianhua Wang, Meng Li, Zhiqiang Shen, Jiawei Wen, Zujia Song, Zhijian Li, Wenjin Xu, Yifeng Wang, Lishan and Shi, Yongyong 2016. A new risk locus in the ZEB2 gene for schizophrenia in the Han Chinese population. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 66, p. 97.
Wen, Zujia Chen, Jianhua Khan, Raja Amjad Waheed Wang, Meng Song, Zhijian Li, Zhiqiang Shen, Jiawei Li, Wenjin and Shi, Yongyong 2016. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population. Journal of Affective Disorders, Vol. 194, p. 180.
Liu, C Saffen, D Schulze, T G Burmeister, M Sham, P C Yao, Y-g Kuo, P-H Chen, C An, Y Dai, J Yue, W Li, M X Xue, H Su, B Chen, L Shi, Y Qiao, M Liu, T Xia, K and Chan, R C K 2016. Psychiatric genetics in China: achievements and challenges. Molecular Psychiatry, Vol. 21, Issue. 1, p. 4.
Huang, Liang Mo, Yin Sun, Xuejin Yu, Hualin Li, Hao Wu, Lichuan and Li, Ming 2016. The impact ofCACNA1Callelic variation on regional gray matter volume in Chinese population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 171, Issue. 3, p. 396.
Rao, Shuquan Yao, Yao Zheng, Chuan Ryan, Joanne Mao, Canquan Zhang, Fuquan Meyre, David and Xu, Qi 2016. Common variants inCACNA1Cand MDD susceptibility: A comprehensive meta-analysis. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Vol. 171, Issue. 6, p. 896.
Quan, Yuan and Zhang, Hong-Yu 2016. A Chemical–Genetic Criterion for Identifying Disease Biomarkers. Trends in Molecular Medicine, Vol. 22, Issue. 6, p. 447.
Pinggera, Alexandra Lieb, Andreas Benedetti, Bruno Lampert, Michaela Monteleone, Stefania Liedl, Klaus R. Tuluc, Petronel and Striessnig, Jörg 2015. CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels. Biological Psychiatry, Vol. 77, Issue. 9, p. 816.
Shelton, Micah A. Newman, Jason T. Gu, Hong Sampson, Allan R. Fish, Kenneth N. MacDonald, Matthew L. Moyer, Caitlin E. DiBitetto, James V. Dorph-Petersen, Karl-Anton Penzes, Peter Lewis, David A. and Sweet, Robert A. 2015. Loss of Microtubule-Associated Protein 2 Immunoreactivity Linked to Dendritic Spine Loss in Schizophrenia. Biological Psychiatry, Vol. 78, Issue. 6, p. 374.
Jiang, Hongyan Qiao, Fei Li, Zongfang Zhang, Yaping Cheng, Yuqi Xu, Xiufeng and Yu, Li 2015. Evaluating the association betweenCACNA1Crs1006737 and schizophrenia risk: A meta-analysis. Asia-Pacific Psychiatry, Vol. 7, Issue. 3, p. 260.
Common psychiatric disorders are highly heritable, indicating that genetic factors play an important role in their aetiology. The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder.
To investigate whether CACNA1C is a susceptibility gene for schizophrenia and major depressive disorder in the Han Chinese population.
We carried out a case–control study of 1235 patients with schizophrenia, 1045 with major depressive disorder and 1235 healthy controls. A tag single nucleotide polymorphism (SNP) rs1006737 along with another 10 tag SNPs in the CACNA1C gene were genotyped in all samples.
We found that rs1006737 was associated with both schizophrenia (P allele = 0.0014, P genotype = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134–1.690) and major depressive disorder (P allele = 0.0007, P genotype = 0.003, OR = 1.425, 95% CI 1.160–1.752).
Our findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.
These authors contributed equally to the work.
This work was supported by the Natural Science Foundation of China (81130022, 81272302, 31000553, 81121001), the National 863 project (2012AA02A515), the 973 Program (2010CB529600), Program for Changjiang Scholars and Innovative Research Team in University (IRT1025), the Foundation for the Author of National Excellent Doctoral Dissertation of China (201026), Shanghai Rising-Star Program (12QA1401900) and ‘Shu Guang’ project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation (12SG17).
Declaration of interest
Email your librarian or administrator to recommend adding this journal to your organisation's collection.
Full text views reflects the number of PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.
* Views captured on Cambridge Core between 2nd January 2018 - 20th March 2018. This data will be updated every 24 hours.