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    Kindler, Jochen Schultze-Lutter, Frauke Hauf, Martinus Dierks, Thomas Federspiel, Andrea Walther, Sebastian Schimmelmann, Benno G and Hubl, Daniela 2018. Increased Striatal and Reduced Prefrontal Cerebral Blood Flow in Clinical High Risk for Psychosis. Schizophrenia Bulletin, Vol. 44, Issue. 1, p. 182.

    Plewnia, Christian Brendel, Bettina Schwippel, Tobias Martus, Peter Cordes, Joachim Hasan, Alkomiet and Fallgatter, Andreas J. 2017. Treatment of auditory hallucinations with bilateral theta burst stimulation (cTBS): protocol of a randomized, double-blind, placebo-controlled, multicenter trial. European Archives of Psychiatry and Clinical Neuroscience,

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Cerebral blood flow alterations specific to auditory verbal hallucinations in schizophrenia

  • Chuanjun Zhuo (a1), Jiajia Zhu (a2), Wen Qin (a2), Hongru Qu (a3), Xiaolei Ma (a3) and Chunshui Yu (a4)...
Abstract
Background

Auditory verbal hallucinations (AVHs) have been associated with deficits in auditory and speech-related networks. However, the resting-state cerebral blood flow (CBF) alterations specific to AVHs in schizophrenia remain unknown.

 Aims

To explore AVH-related CBF alterations in individuals with schizophrenia.

 Method

In total, 35 individuals with schizophrenia with AVHs, 41 individuals with schizophrenia without AVHs and 50 controls underwent arterial spin labelling magnetic resonance imaging. The CBF differences were voxel-wise compared across the three groups.

 Results

We found AVH-specific CBF increase in the right superior temporal gyrus and caudate, and AVH-specific CBF decrease in the bilateral occipital and left parietal cortices. We also observed consistent CBF changes in both schizophrenia subgroups (i.e. those with and without AVHs) including decreased CBF in the bilateral occipital regions, the left lateral prefrontal and insular cortices, and the right anterior cingulate cortex and increased CBF in the bilateral lateral temporal regions and putamen, the left middle cingulate cortex and the right thalamus.

 Conclusions

The AVH-specific CBF increases in the auditory and striatal areas and CBF reductions in the visual and parietal areas suggest that there exists a CBF redistribution associated with AVHs.
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Copyright
COPYRIGHT: © Royal College of Psychiatrists, 2017 
Corresponding author
Chunshui Yu, MD, Department of Radiology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin 300052, China. Email: chunshuiyu@tijmu.edu.cn
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*

These authors contributed equally to this work.

Declaration of interest

None.

Footnotes
References
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  • Cited by 2
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Kindler, Jochen Schultze-Lutter, Frauke Hauf, Martinus Dierks, Thomas Federspiel, Andrea Walther, Sebastian Schimmelmann, Benno G and Hubl, Daniela 2018. Increased Striatal and Reduced Prefrontal Cerebral Blood Flow in Clinical High Risk for Psychosis. Schizophrenia Bulletin, Vol. 44, Issue. 1, p. 182.

    Plewnia, Christian Brendel, Bettina Schwippel, Tobias Martus, Peter Cordes, Joachim Hasan, Alkomiet and Fallgatter, Andreas J. 2017. Treatment of auditory hallucinations with bilateral theta burst stimulation (cTBS): protocol of a randomized, double-blind, placebo-controlled, multicenter trial. European Archives of Psychiatry and Clinical Neuroscience,

    ×
  • Access

Cerebral blood flow alterations specific to auditory verbal hallucinations in schizophrenia

  • Chuanjun Zhuo (a1), Jiajia Zhu (a2), Wen Qin (a2), Hongru Qu (a3), Xiaolei Ma (a3) and Chunshui Yu (a4)...
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