It has been estimated (Zellweger, 1961) that less than 5 per cent of all cases of mental subnormality have a hereditary metabolic defect. This is a figure which requires confirmation, and is one that is likely to vary in different parts of the world. We have accordingly carried out a systematic clinical and biochemical screening of the cases of mental subnormality (IQ lower than 70) attending the out-patient department of the Mental Hospital, Bangalore. A total of 729 patients (439 males and 290 females) were available for this study.
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