1Dell'Osso, L, Del Grande, C, Gesi, C, Carmassi, C, Musetti, L. A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts. Neuropsychiatr Dis Treat 2016; 12: 1687–703.
2Forlenza, OV, Aprahamian, I, de Paula, VJ, Hajek, T. Lithium, a therapy for AD: current evidence from clinical trials of neurodegenerative disorders. Curr Alzheimer Res 2016; 13: 879–86.
3Nunes, PV, Forlenza, OV, Gattaz, WF. Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder. Br J Psychiatry 2007; 190: 359–60.
4Kessing, LV, Søndergård, L, Forman, JL, Andersen, PK. Lithium treatment and risk of dementia. Arch Gen Psychiatry 2008; 65: 1331–5.
5Moore, GJ, Bebchuk, JM, Wilds, IB, Chen, G, Manji, HK. Lithium-induced increase in human brain grey matter. Lancet 2000; 356: 1241–2.
6Zung, S, Souza-Duran, FL, Soeiro-de-Souza, MG, Uchida, R, Bottino, CM, Busatto, GF, et al. The influence of lithium on hippocampal volume in elderly bipolar patients: a study using voxel-based morphometry. Transl Psychiatry 2016; 6: e846.
7Hajek, T, Bauer, M, Pfennig, A, Cullis, J, Ploch, J, O'Donovan, C, et al. Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study. J Psychiatry Neurosci 2012; 37: 185–92.
8Kessing, LV, Gerds, TA, Knudsen, NN, Jørgensen, LF, Kristiansen, SM, Voutchkova, D, et al. Association of lithium in drinking water with the incidence of dementia. JAMA Psychiatry 2017; 74: 1005–10.
9Fajardo, VA, Fajardo, VA, LeBlanc, PJ, MacPherson, REK. Examining the relationship between trace lithium in drinking water and the rising rates of age-adjusted Alzheimer's disease mortality in Texas. J Alzheimers Dis 2018; 61: 425–34.
10Morris, G, Berk, M. The putative use of lithium in Alzheimer's disease. Curr Alzheimer Res 2016; 13: 853–61.
11Macdonald, A, Briggs, K, Poppe, M, Higgins, A, Velayudhan, L, Lovestone, S. A feasibility and tolerability study of lithium in Alzheimer's disease. Int J Geriatr Psychiatry 2008; 23: 704–11.
12Hampel, H, Ewers, M, Burger, K, Annas, P, Mortberg, A, Bogstedt, A, et al. Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo- controlled, multicenter 10-week study. J Clin Psychiatry 2009; 70: 922–3.
13Forlenza, OV, Diniz, BS, Radanovic, M, Santos, FS, Talib, LL, Gattaz, WF. Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br J Psychiatry 2011; 198: 351–6.
14Nunes, MA, Viel, TA, Buck, HS. Microdose lithium treatment stabilized cognitive impairment in patients with Alzheimer's disease. Curr Alz Res 2013; 10: 104–7.
15Matsunaga, S, Kishi, T, Annas, P, Basun, H, Hampel, H, Iwata, N. Lithium as a treatment for Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis 2015; 48: 403–10.
16Petersen, RC, Smith, GE, Waring, SC, Ivnik, RJ, Tangalos, EG, Kokmen, E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999; 56: 303–8.
17Lingjaerde, O, Ahlfors, UG, Bech, P, Dencker, SJ, Elgen, K. The UKU side effect rating scale. A new comprehensive rating scale for psychotropic drugs and a cross-sectional study of side effects in neuroleptic-treated patients. Acta Psychiatr Scand 1987; 334 (suppl): 1–100.
18Rosen, WG, Mohs, RC, Davis, KL. A new rating scale for Alzheimer's disease. Am J Psychiatry 1984; 141: 1356–64.
19Morris, JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993; 43: 2412–4.
20Army Individual Test Battery, . Manual of Directions and Scoring. , 1944.
21Wechsler, D. Wechsler Adult Intelligence Scale-III (WAIS-III) Manual. , 1977.
22Aprahamian, I, Santos, FS, Santos, B, Talib, L, Diniz, BS, Radanovic, M, et al. Long-term, low-dose lithium treatment does not impair renal function in the elderly: a two-year placebo-controlled trial followed by single-blind extension. J Clin Psychiatry 2014; 75: 672–8.
23Forlenza, OV, Radanovic, M, Talib, LL, Aprahamian, I, Diniz, BS, Zetterberg, H, et al. Cerebrospinal fluid biomarkers in Alzheimer's disease: diagnostic accuracy and prediction of dementia. Alzheimers Dement 2015; 1: 455–63.
24Chen, G, Rajkowska, G, Du, F, Seraji-Bozorgzad, N, Manji, HK. Enhancement of hippocampal neurogenesis by lithium. J Neurochem 2000; 75: 1729–34.
25Forlenza, OV, De-Paula, VJ, Diniz, BS. Neuroprotective effects of lithium: implications for the treatment of Alzheimer's disease and related neurodegenerative disorders. ACS Chem Neurosci 2014; 5: 443–50.
26Phiel, CJ, Wilson, CA, Lee, VM, Klein, PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 2003; 423: 435–9.