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Cognitive–behavioural therapy with post-session d-cycloserine augmentation for paediatric obsessive–compulsive disorder: pilot randomised controlled trial

  • David Mataix-Cols (a1), Cynthia Turner (a1), Benedetta Monzani (a1), Kayoko Isomura (a1), Caroline Murphy (a1), Georgina Krebs (a1) and Isobel Heyman (a1)...
Summary

A partial N-methyl-d-aspartate agonist, d-cycloserine, enhances fear extinction when given before or shortly after exposure to feared stimuli in animals. In this pilot double-blind placebo-controlled trial (trial number: ISRCTN70977225), 27 youth with obsessive–compulsive disorder were randomised to either 50mg d-cycloserine or placebo administered immediately after each of ten cognitive–behavioural therapy (CBT) sessions, primarily consisting of exposure and ritual prevention. Both groups improved significantly and maintained their gains at 1-year follow-up, with no significant advantage of d-cycloserine over placebo at any time point. The effects of CBT may not be augmented or accelerated when d-cycloserine is administered after sessions.

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      Cognitive–behavioural therapy with post-session d-cycloserine augmentation for paediatric obsessive–compulsive disorder: pilot randomised controlled trial
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Copyright
Corresponding author
David Mataix-Cols, PhD. King's College London, Institute of Psychiatry, Box PO69, De Crespigny Park, London SE5 8AF, UK. Email: david.mataix-cols@kcl.ac.uk
Footnotes
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The authors acknowledge financial support from the Department of Health via the National Institute for Health Research (NIHR) Specialist Biomedical Research Centre for Mental Health award to South London and Maudsley NHS Foundation Trust (SLaM) and the Institute of Psychiatry at King's College London.

Declaration of interest

None.

Footnotes
References
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Cognitive–behavioural therapy with post-session d-cycloserine augmentation for paediatric obsessive–compulsive disorder: pilot randomised controlled trial

  • David Mataix-Cols (a1), Cynthia Turner (a1), Benedetta Monzani (a1), Kayoko Isomura (a1), Caroline Murphy (a1), Georgina Krebs (a1) and Isobel Heyman (a1)...
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