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Continuing Clozapine Despite Neutropenia

  • Michael L. Wesson (a1), David M. Finnegan (a1) and Peter I. Clark (a2)

A 40-year-old chronic schizophrenic patient whose psychosis and associated violent behaviour resolved on clozapine, required chemotherapy for a testicular teratoma with pulmonary metastases. His treatment was initially delayed due to refusal to consent.


The patient finally agreed to orchidectomy and cytotoxic therapy, and following agreement by the CPMS, clozapine continued to be dispensed despite neutropenia and ‘red alert’ status on full blood count.


This is the only patient to continue clozapine despite ‘red alert’ status, and as such is an exceptional case, but may open the way for such patients in the future.

Corresponding author
Michael L. Wesson, Mossley House, Mossley Hill Hospital, Park Avenue, Mossley Hill, Liverpool L18 8BU
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Alvir, J. M. J., Lieberman, J. A., Safferman, A. Z., et al (1993) Clozapine induced agranulocytosis: incidence and risk factors in the United States. New England Journal of Medicine, 329, 162167.
Atkin, K. & Veys, P. (1994) Clozapine-induced neutropenia, or not (letter). British Journal of Psychiatry, 165, 407408.
Beer, D., Cope, S., Paton, C., et al (1994) Clozapine-induced neutropenia – or not (letter). British Journal of Psychiatry, 164, 850.
Re C High Court of Justice (Family Division) (1993) Case number 6703/93.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Continuing Clozapine Despite Neutropenia

  • Michael L. Wesson (a1), David M. Finnegan (a1) and Peter I. Clark (a2)
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