Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-19T06:44:41.691Z Has data issue: false hasContentIssue false
  • English
  • Français

Correlations Between Akathisia and Residual Psychopathology: A By-product of Neuroleptic-Induced Dysphoria

Published online by Cambridge University Press:  02 January 2018

John W. Newcomer ,
L. Stephen Miller ,
William O. Faustman ,
Martin W. Wetzel ,
George P. Vogler  and
John G. Csernansky
John W. Newcomer*
Affiliation:
Department of Psychiatry, Washington University School of Medicine, 4940 Children's Place, St Louis, Missouri 63110, USA
L. Stephen Miller
Affiliation:
Department of Psychology, University of Georgia, Athens GA
William O. Faustman
Affiliation:
Department of Veteran Affairs Medical Center, Palo Alto, CA, and the Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, Stanford, CA
Martin W. Wetzel
Affiliation:
Department of Psychiatry, Washington University School of Medicine
George P. Vogler
Affiliation:
Department of Biostatistics, Washington University School of Medicine
John G. Csernansky
Affiliation:
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

Patients developing neuroleptic-induced akathisia have been reported to show higher levels of psychopathology. We sought to replicate this finding and determine its symptom specificity. We confirmed a significant relationship between ratings of akathisia and total score on the Brief Psychiatric Rating Scale (BPRS) during both acute and maintenance neuroleptic treatment. Using stepwise regression models, BPRS anxious-depressive subscale scores were the strongest predictors of akathisia during both treatment conditions. Paranoid subscale scores predicted akathisia only during maintenance treatment. These results suggest that neuroleptic-induced dysphoria largely explains the relationship between akathisia and residual psychopathology during both acute and maintenance neuroleptic treatment.

Type
Short papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 6 , June 1994 , pp. 834 - 838
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Barnes, T. R. E. & Braude, W. M. (1985) Akathisia variants and tardive dyskinesia. Archives of General Psychiatry, 42, 874–878.Google Scholar
Gerlach, J. (1979) Tardive dyskinesia. Danish Medical Bulletin, 26, 209–254.Google Scholar
Levinson, D. F., Simpson, G. M., Singh, H., et al (1990) Fluphenazine dose, clinical response, and extrapyramidal symptoms during acute treatment. Archives of General Psychiatry, 47, 761–768.CrossRefGoogle ScholarPubMed
Marder, S. R., Van Putten, T., Mintz, J., et al (1984) Costs and benefits of two doses of fluphenazine. Archives of General Psychiatry, 41, 1025–1029.Google Scholar
Newcomer, J. W., Riney, S. J., Vinogradov, S., et al (1992) Plasma prolactin and homovanillic acid as markers for psychopathology and abnormal movements after neuroleptic dose decrease. Psychopharmacology Bulletin, 28, 101–107.Google Scholar
Overall, J. E. (1974) A Brief Psychiatric Rating Scale in psychopharmacology research. In Psychological Measurements in Psychopharmacology, Modern Problems in Pharmacopsychiatry, Volume 7 (ed. Pichot, P.), pp. 67–78. Basel: Karger.Google Scholar
Petrie, E. C., Faustman, W. O., Moses, J. A., et al (1990) Correlates of rapid neuroleptic response in male patients with schizophrenia. Psychiatry Research, 33, 171–177.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: Rationale and reliability. Archives of General Psychiatry, 35, 773–791.Google Scholar
Van Putten, T. & May, P. R. A. (1978) Subjective response as a predictor of outcome in pharmacotherapy. Archives of General Psychiatry, 35, 477–480.Google Scholar
Van Putten, , Marder, S. R., May, P. R. A., et al (1985) Plasma levels of haloperidol and clinical response. Psychopharmacology Bulletin, 21, 69–72.Google ScholarPubMed
Van Putten, , Marder, S. R., & Mintz, J. (1990) A controlled dose comparison of haloperidol in newly admitted schizophrenic patients. Archives of General Psychiatry, 47, 754–758.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.