Gottesman, II, Laursen, TM, Bertelsen, A, Mortensen, PB. Severe mental disorders in offspring with 2
psychiatrically ill parents. Arch Gen
2010; 67: 252–7.
Farmer, A, Elkin, A, McGuffin, P. The genetics of bipolar affective
disorder. Curr Opin Psychiatry
Hamshere, ML, O'Donovan, MC, Jones, IR, Jones, L, Kirov, G, Green, EK, et al.
Polygenic dissection of the bipolar
phenotype. Br J Psychiatry
2011; 198: 284–8.
The early natural history of bipolar disorder: what we have
learned from longitudinal high-risk research. Can
2010; 55: 477–85.
Leboyer, M, Henry, C, Paillere-Martinot, ML, Bellivier, F. Age at onset in bipolar affective disorders: a
review. Bipolar Disord
2005; 7: 111–8.
Angst, J, Sellaro, R.
Historical perspectives and natural history of bipolar
disorder. Biol Psychiatry
2000; 48: 445–57.
Shaw, JA, Egeland, JA, Endicott, J, Allen, CR, Hostetter, AM. A 10-year prospective study of prodromal patterns
for bipolar disorder among Amish youth. J Am Acad
Child Adolesc Psychiatry
2005; 44: 1104–11.
McGuffin, P, Perroud, N, Uher, R, Butler, A, Aitchison, KJ, Craig, I, et al.
The genetics of affective disorder and
suicide. Eur Psychiatry
2010; 25: 275–7.
The phenotypic spectra of bipolar disorder.
2004; 14: 94–9.
Sixty years of lithium responders.
Grof, P, Duffy, A, Alda, M, Hajek, T. Lithium response across generations.
Acta Psychiatr Scand
2009; 120: 378–85.
Duffy, A, Doucette, S, Lewitzka, U, Alda, M, Hajek, T, Grof, P. Findings from bipolar offspring studies: methodology
matters. Early Interv Psychiatry
2011; 5: 181–91.
DelBello, MP, Geller, B. Review of studies of child and adolescent offspring
of bipolar parents. Bipolar Disord
2001; 3: 325–34.
Hillegers, MH, Reichart, CG, Wals, M, Verhulst, FC, Ormel, J, Nolen, WA. Five-year prospective outcome of psychopathology in
the adolescent offspring of bipolar parents.
2005; 7: 344–50.
Duffy, A, Alda, M, Hajek, T, Grof, P. Early course of bipolar disorder in high-risk
offspring: prospective study. Br J
2009; 195: 457–8.
The nature of the association between childhood ADHD and the
development of bipolar disorder: a review of prospective high-risk
studies. Am J Psychiatry
2012; 169: 1247–55.
Duffy, A, Alda, M, Hajek, T, Sherry, SB, Grof, P. Early stages in the development of bipolar
disorder. J Affect Disord
2010; 121: 127–35.
Duffy, A, Alda, M, Crawford, L, Milin, R, Grof, P. The early manifestations of bipolar disorder: a
longitudinal prospective study of the offspring of bipolar
parents. Bipolar Disord
2007; 9: 828–38.
American Psychiatric Association.
Diagnostic and Statistical Manual of Mental Disorders
(4th edn) .
Endicott, J, Spitzer, RL.
A diagnostic interview: the schedule for affective disorders
and schizophrenia. Arch Gen Psychiatry
1978; 35: 837–44.
Kalbfleisch, JP, Prentice, RL.
The Statistical Analysis of Failure Time Data (2nd
edn). John Wiley & Sons,
MSM: Multi-state Markov and hidden Markov models in continuous time
(computer program). .
Sakamoto, Y, Ishiguro, M, Kitagawa, G. Akaike Information Criterion Statistics.
Team, RDC. A language and Environment for Statistical
Computing. R Foundation for Statistical
Commentary on “the indiscriminate state of social class
measurement”. Social Forces
1971; 49: 563–7.
Duffy, A, Horrocks, J, Milin, R, Doucette, S, Persson, G, Grof, P. Adolescent substance use disorder during the early
stages of bipolar disorder: a prospective high-risk
study. J Affect Disord
Nurnberger, JI Jr, McInnis, M, Reich, W, Kastelic, E, Wilcox, HC, Glowinski, A, et al.
A high-risk study of bipolar disorder. Childhood clinical
phenotypes as precursors of major mood disorders.
Arch Gen Psychiatry
2011; 68: 1012–20.
St Clair, D.
Structural and copy number variants in the human genome:
implications for psychiatry. Br J
Grof, P, Alda, M, Grof, E, Zvolsky, P, Walsh, M. Lithium response and genetics of affective
disorders. J Affect Disord
McGorry, PD, Nelson, B, Goldstone, S, Yung, AR. Clinical staging: a heuristic and practical strategy
for new research and better health and social outcomes for psychotic and
related mood disorders. Can J Psychiatry
2010; 55: 486–97.