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Difficulties of diagnosing and managing dementia in people with Down syndrome

  • David Smith (a1) and Brian Chicoine (a2)
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1Eady, N, Sheehan, R, Rantell, K, Sinai, A, Bernal, J, Bohnen, I, et al. Impact of cholinesterase inhibitors or memantine on survival in adults with Down syndrome and dementia: clinical cohort study. Br J Psychiatry 2018; 212: 155–60.
2Mohan, M, Carpenter, PK, Bennett, C. Donepezil for dementia in people with Down syndrome. Cochrane Database Syst Rev 2009; 1: CD007178.
3Mohan, M, Bennett, C, Carpenter, PK. Rivastigmine for dementia in people with Down syndrome. Cochrane Database Syst Rev 2009; 1: CD007658.
4McShane, R, Areosa Sastre, A, Minakaran, N. Memantine for dementia. Cochrane Database Syst Rev 2006; 2: CD003154.
5Hanney, M, Prasher, V, Williams, N, Jones, EL, Aarsland, D, Corbett, A, et al. Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial. Lancet 2012; 379: 528–36.
6Mohan, M, Bennett, C, Carpenter, PK. Galantamine for dementia in people with Down syndrome. Cochrane Database Syst Rev 2009; 1: CD007656.
7Livingstone, N, Hanratty, J, McShane, R, Macdonald, G. Pharmacological interventions for cognitive decline in people with Down syndrome. Cochrane Database Syst Rev 2015; 10: CD011546.
8Chicoine, B, McGuire, D, Hebein, S, Gilly, D. Development of a clinic for adults with Down syndrome. Ment Retard 1994; 32: 100–6.
9Wisniewski, KE, Wisniewski, HM, Wen, GY. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann Neurol 1985; 17: 278–82.
10Wisniewski, HM, Rabe, A. Discrepancy between Alzheimer-type neuropathology and dementia in persons with Down's syndrome. Ann N Y Acad Sci 1986; 477: 247–60.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Difficulties of diagnosing and managing dementia in people with Down syndrome

  • David Smith (a1) and Brian Chicoine (a2)
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