Skip to main content
×
×
Home

Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD

  • Cleo L. Crunelle (a1), Wim van den Brink (a2), Geert Dom (a3) and Jan Booij (a4)
Summary

Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD
      Available formats
      ×
Copyright
Corresponding author
C. L. Crunelle, Collaborative Antwerp Psychiatric Research Institute (CAPRI) - University of Antwerp, Campus Drie Eiken, Universiteitsplein 1-R.3.27, 2610 Antwerp (Wilrijk), Belgium. Email: cleo.crunelle@gmail.com
Footnotes
Hide All

Grant to W.v.d.B. from ZonMW.

Declaration of interest

W.v.d.B. received fees from Eli Lilly unrelated to the present work. G.D. received fees from Lundbeck, Janssen Pharmaceuticals and Eli Lilly unrelated to the present work. J.B. has received consultancy payments from GE Healthcare.

Footnotes
References
Hide All
1 Broos, N, Schmaal, L, Wiskerke, J, Kostelijk, L, Lam, T, Stoop, N, et al. The relationship between impulsive choice and impulsive action: a cross-species translational study. PLoS One 2012; 7: e36781.
2 Biederman, J, Petty, CR, Evans, M, Small, J, Faraone, SV. How persistent is ADHD? A controlled 10-year follow-up study of boys with ADHD. Psychiatry Res 2010; 177: 299304.
3 Costa, A, la Fougère, C, Pogarell, O, Möller, HJ, Riedel, M, Ettinger, U. Impulsivity is related to striatal dopamine transporter availability in healthy males. Psychiatry Res 2013; 211: 251–6.
4 Burke, SM, van de Giessen, E, de Win, M, Schilt, T, van Herk, M, van den Brink, W, et al. Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects. Psychol Med 2012; 41: 419–29.
5 Fusar-Poli, P, Rubia, K, Rossi, G, Sartori, G, Balottin, U. Striatal dopamine transporter alterations in ADHD: pathophysiology or adaptation to psychostimulants? A meta-analysis. Am J Psychiatry 2013; 169: 264–72.
6 Crunelle, CL, van den Brink, W, Veltman, DJ, van Emmerik-van Oortmerssen, K, Dom, G, Schoevers, RA, et al. Low dopamine transporter occupancy by methylphenidate as a possible reason for reduced treatment effectiveness in ADHD patients with cocaine dependence. Eur Neuropsychopharmacol 2013; 23: 1714–23.
7 Crunelle, CL, Veltman, DJ, van Emmerik-van Oortmerssen, K, Booij, J, van den Brink, W. Impulsivity in adult ADHD patients with and without cocaine dependence. Drug Alcohol Depend 2013; 129: 1824.
8 Bickel, WK, Marsch, LA. Toward a behavioral economic understanding of drug dependence: delay discounting processes. Addiction 2001; 96: 7386.
9 Logan, GD, Cowan, WB, Davis, KA. On the ability to inhibit simple and choice reaction time responses: a model and a method. J Exp Psychol Hum Percept Perform 1984; 10: 276–91.
10 Kooij, JJ, Buitelaar, JK, van den Oord, EJ, Furer, JW, Rijnders, CA, Hodiamont, PP. Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychol Med 2005; 35: 817–27.
11 Heatherton, TF, Kozlowski, LT, Frecker, RC, Fagerström, KO. The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict 1991; 86: 1119–27.
12 Patton, JH, Stanford, MS, Barratt, ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol 1995; 51: 768–74.
13 Wilbertz, G, van Elst, LT, Delgado, MR, Maier, S, Feige, B, Philipsen, A, et al. Orbitofrontal reward sensitivity and impulsivity in adult attention deficit hyperactivity disorder. NeuroImage 2012; 60: 353–61.
14 Yu, D. Additional brain functional network in adults with attention-deficit/hyperactivity disorder: a phase synchrony analysis. PLoS One 2013; 8: e54516.
15 Krause, J. SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder. Expert Rev Neurother 2008; 8: 611–25.
16 Ramos-Quiroga, JA, Montoya, A, Kutzelnigg, A, Deberdt, W, Sobanski, E. Attention deficit hyperactivity disorder in the European adult population: prevalence, disease awareness, and treatment guidelines. Curr Med Res Opin 2013; 29: 1093–104.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×
Type Description Title
PDF
Supplementary materials

Crunelle et al. supplementary material
Supplementary Figure S1

 PDF (451 KB)
451 KB

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 24 *
Loading metrics...

Abstract views

Total abstract views: 76 *
Loading metrics...

* Views captured on Cambridge Core between 3rd January 2018 - 27th April 2018. This data will be updated every 24 hours.

Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD

  • Cleo L. Crunelle (a1), Wim van den Brink (a2), Geert Dom (a3) and Jan Booij (a4)
Submit a response

eLetters

Cognitive Impulsivity in ADHD

Zoe R Ellison-Wright, Consultant Child Psychiatrist
13 June 2014

The findings of Crunelle et al (1) are interesting in providing evidence for the role of the putamen in the mechanism of methylphenidate treatment of adult ADHD, specifically in improving cognitive impulsivity assessed by a delayed discounting task. In practice, cognitive impulsivityin people with ADHD may contribute to acting for immediate rewards and risk-taking behaviour.

The putamen has also been implicated in regulation of cognitive impulsivity in a functional MRI study of healthy controls by Kayser et al (2). They found that the drug tolcapone, which raises frontal cortical dopamine levels, attenuated impulsive choice in the control subjects and this covaried with increased functional activity in the left putamen and insula.

The putamen may be a critical region in the pathology of ADHD. Meta-analyses of voxel-based structural imaging studies found regional gray matter reductions in the right putamen/globus pallidus region in subjects with ADHD (3, 4) extending to include the right caudate (4). A meta-analysis of functional studies of ADHD also identified reduced activation in networks of brain regions including the putamen in both inhibition and attention tasks (5).

The Crunelle et al paper suggests that the therapeutic modulation of putamen dopamine may have a more complex effect on cerebral network dynamics than previously realised, reflecting the role of the putamen as anode in multiple brain networks, subserving a variety of psychological processes and leading to multiple impairments for people with ADHD.

In the future, new drugs with tolcapone-like effects may more specifically reduce cognitive impulsivity in ADHD.

1. Crunelle CL, van den Brink W, Dom G, Booij J. Dopamine transporteroccupancy by methylphenidate and impulsivity in adult ADHD. Br J Psychiatry 2014; 204:486-487.

2. Kayser AS, Allen DC, Navarro-Cebrian A, Mitchell JM, Fields HL. Dopamine, Corticostriatal Connectivity, and Intertemporal Choice. Journal Neurosci 2012; 32:9402-9409.

3. Ellison-Wright I, Ellison-Wright Z, Bullmore E. Structural brain change in Attention Deficit Hyperactivity Disorder identified by meta- analysis. BMC Psychiatry 2008; 8:51.

4. Nakao T, Radua J, Rubia K, Mataix-Cols D. Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication. Am J Psychiatry 2011; 168:1154-63.

5. Hart H, Radua J, Nakao T, Mataix-Cols D, Rubia K. Meta-analysis offunctional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: exploring task-specific, stimulant medication, and age effects. JAMA Psychiatry 2013; 70:185-98.

... More

Conflict of interest: None declared

Write a reply

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *