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Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

  • Akihiro Takamiya (a1), Jun Ku Chung (a2), Kuo-ching Liang (a3), Ariel Graff-Guerrero (a4), Masaru Mimura (a3) and Taishiro Kishimoto (a5)...

Abstract

Background

Electroconvulsive therapy (ECT) is one of the most effective treatments for depression, although the underlying mechanisms remain unclear. Animal studies have shown that electroconvulsive shock induced neuroplastic changes in the hippocampus.

Aims

To summarise volumetric magnetic resonance imaging studies investigating the effects of ECT on limbic brain structures.

Method

A systematic review and meta-analysis was conducted to assess volumetric changes of each side of the hippocampus and amygdala before and after ECT. Standardised mean difference (SMD) was calculated.

Results

A total of 8 studies (n = 193) were selected for our analyses. Both right and left hippocampal and amygdala volumes increased after ECT. Meta-regression analyses revealed that age, percentage of those responding and percentage of those in remission were negatively associated with volume increases in the left hippocampus.

Conclusions

ECT increased brain volume in the limbic structures. The clinical relevance of volume increase needs further investigation.

Declaration of interest

None.

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Copyright

Corresponding author

Correspondence: Dr Taishiro Kishimoto, Keio University School of Medicine, Department of Neuropsychiatry, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. Email: tkishimoto@keio.jp

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Effect of electroconvulsive therapy on hippocampal and amygdala volumes: systematic review and meta-analysis

  • Akihiro Takamiya (a1), Jun Ku Chung (a2), Kuo-ching Liang (a3), Ariel Graff-Guerrero (a4), Masaru Mimura (a3) and Taishiro Kishimoto (a5)...
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