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Effects of a History of Heavy Alcohol Consumption on Alzheimer's Disease

  • Jules Rosen (a1), Angela Colantonio (a2), James T. Becker (a3), Oscar L. Lopez (a4), Steven T. Dᴇkosky (a3) and Howard B. Moss (a5)...


Neuropsychological and psychiatric evaluations were made of 39 subjects with possible Alzheimer's disease and a history of excessive alcohol consumption (AD + ETOH), who had been abstinent or had drunk minimally for at least three months before evaluation, and 225 patients with probable Alzheimer's disease (PAD) of comparable age, years of education, and baseline global impairment. At baseline, there were no significant differences between the groups in terms of age of onset of dementia, neuropsychological test scores, or current behavioural or psychiatric symptoms. One year later, no differences in rates of decline between 20 abstinent AD + ETOH patients and 88 PAD subjects could be shown. Thus, past heavy alcohol consumption does not appear to modify the presentation of dementia of the Alzheimer's type, nor does it modify progression over a one-year interval.


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Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA


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American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM-III-R). Washington, DC: APA.
Ancoli-Israel, S., Klauber, M. R., Butters, N., et al (1991) Dementia in institutionalized elderly: relation to sleep apnea. Journal of the American Geriatrics Society, 39, 258263.
Arendt, T., Henning, D., Gray, J. A., et al (1988) Loss of neurons in the rat basal brain cholinergic projection system after prolonged intake of ethanol. Brain Research Bulletin, 21, 563569.
Barclay, L. L., Zemcov, A., Blass, J. P., et al (1985) Factors associated with duration of survival in Alzheimer's disease. Biological Psychiatry, 20, 8693.
Benton, A. L., Hamsher, K., Varney, N. R., et al (1983) Contributions to Neuropsychological Assessment: A Clinical Manual. New York: Oxford University Press.
Boller, F., Lopez, O. L. & Moossy, J. (1989) Diagnosis of dementia: clinicopathologic correlations. Neurology, 39, 7679.
Brandt, J., Butters, N., Ryan, C., et al (1983) Cognitive loss and recovery in long-term alcohol abusers. Archives of General Psychiatry, 40, 435442.
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975) ‘Mini Mental State’: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Hachinski, V. C., Iliff, L. D., Zilhka, E., et al (1975) Cerebral blood flow in dementia. Archives of Neurology, 32, 632637.
Hansen, L. A., Natelson, B. H., Lemere, C., et al (1991) Alcohol-induced brain changes in dogs. Archives of Neurology, 48, 939942.
Huff, F. J., Corkin, S. & Growdon, J. H. (1986) Semantic impairment and anomia in Alzheimer's disease. Brain and Language, 28, 235249.
Huff, F. J., Corkin, S. & Growdon, J. H., Mack, L., Mahlman, J., et al (1988a) A comparison of lexical semantic impairments in left hemisphere stroke and Alzheimer's disease. Brain and Language, 34, 262278.
Huff, F. J., Corkin, S. & Growdon, J. H., Mack, L., Mahlman, J., Protetch, J., Saxton, J., et al (1988b) Subscales of the Mattis Dementia Rating Scale: development and application in patients with Alzheimer's and vascular dementia. Journal of the American Geriatrics Society, 36, 672675.
Hughes, C. P., Berg, L., Danziger, W. L., et al (1982) A new clinical scale for the staging of dementia. British Journal of Psychiatry, 140, 566572.
Jones, B. & Parsons, O. A. (1971) Impaired subtracting ability in chronic alcoholics. Archives of General Psychiatry, 24, 7175.
Jones, B. & Parsons, O. A. (1972) Specific vs. generalized deficits of abstracting ability in chronic alcoholics. Archives of General Psychiatry, 26, 380384.
Kaszniak, A. W., Wilson, R. S., Fox, J. H., et al (1986) Cognitive assessment in Alzheimer's disease: cross-sectional and longitudinal perspectives. Canadian Journal of Neurological Science, 13, 420423.
Lishman, W. A. (1986) Alcoholic dementia: a hypothesis. Lancet, i, 11841186.
Lopez, O. L., Swihart, A. A., Becker, J. T., et al (1990) Reliability of NINCDS-ADRDA clinical criteria for the diagnosis of Alzheimer's disease. Neurology, 40, 15171522.
Mattis, S. (1976) Mental status examination for organic mental syndrome in the elderly patient. In Geriatric Psychiatry: A Handbook for Psychiatrists and Primary Care Physicians (eds Beliak, L. & Karasu, T. B.), pp. 77121. New York: Grune & Stratton.
McKhann, G., Drachman, D., Folstein, M., et al (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939944.
Mezzich, J. E., Dow, J. T., Rich, C. L., et al (1981) Developing an efficient clinical information system for a comprehensive psychiatric institute: II. Initial evaluation form. Behavioural Research Methods and Instruments, 13, 464478.
Mezzich, J. E., Dow, J. T., Rich, C. L., Fabrega, H., Coffman, G. A., et al (1987) Comprehensively diagnosing geriatric patients. Comprehensive Psychiatry, 28, 6876.
Raven, J. C. (1956) Coloured Progressive Matrices. Los Angeles, CA: Western Psychological Services.
Rocca, W. A., Amaducci, L. A. & Schoenberg, B. S. (1986) Epidemiology of clinically diagnosed Alzheimer's disease. Annals of Neurology, 19, 415424.
Rosen, J. & Zubenko, G. S. (1991) Emergence of psychosis and depression in the longitudinal evaluation of Alzheimer's disease. Biological Psychiatry, 29, 224232.
Ryan, C. & Butters, N. (1980) Learning and memory impairments in young and old alcoholics: evidence for the premature-aging hypothesis. Alcoholism: Clinical and Experimental Research, 4, 288293.
Salmon, D. P., Kwo-on-Yuen, P. F., Heindel, W. C., et al (1989) Differentiation of Alzheimer's disease and Huntington's disease with the Dementia Rating Scale. Archives of Neurology, 46, 12041208.
Saunders, P. A., Copeland, J. R. M., Dewey, M. E., et al (1991) Heavy drinking as a risk factor for depression and dementia in elderly men: findings from the Liverpool longitudinal community study. British Journal of Psychiatry, 159, 213216.
Stern, Y., Mayeux, R., Sano, M., et al (1987) Predictors of disease course in patients with probable Alzheimer's disease. Neurology, 37, 16491653.
Tarter, R. E. (1975) Brain damage associated with chronic alcoholism. Diseases of the Nervous System, 36, 185187.
Tarter, R. E. & Parsons, O. (1971) Conceptual shifting in chronic alcoholics. Journal of Abnormal Psychology, 77, 7175.
Tarter, R. E. & Parsons, O., Van Thiel, D. H., Arria, A. M., et al (1988) Impact of cirrhosis on the neuropsychological test performances of alcoholics. Alcoholism: Clinical and Experimental Research, 12, 619621.
Teri, L., Hughes, J. P. & Larson, E. B. (1990) Cognitive deterioration in Alzheimer's disease: behavioural and health factors. Journal of Gerontology, 45, 5863.
Victor, M. & Adams, R. D. (1985) The alcoholic dementias. In Handbook of Clinical Neurology, Vol. 2 (ed. Frederiks, J. A. M.), pp. 335352. Amsterdam: Elsevier.
Victor, M. & Adams, R. D. & Collins, G. H. (1989) The Wernicke-Korsakoff syndrome and related neurologic disorders due to alcoholism and malnutrition. Contemporary Neurology Series, Vol. 3, pp. 119128. Philadelphia: F. A. Davis.
Wechsler, D. (1945) A standardized memory scale for clinical use. Journal of Psychology, 19, 8795.


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Effects of a History of Heavy Alcohol Consumption on Alzheimer's Disease

  • Jules Rosen (a1), Angela Colantonio (a2), James T. Becker (a3), Oscar L. Lopez (a4), Steven T. Dᴇkosky (a3) and Howard B. Moss (a5)...
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