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  • Cited by 18
  • Cited by
    Crossref Citations
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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Veselinović, Tanja Vernaleken, Ingo Janouschek, Hildegard Kellermann, Thilo Paulzen, Michael Cumming, Paul and Gründer, Gerhard 2015. Effects of anticholinergic challenge on psychopathology and cognition in drug-free patients with schizophrenia and healthy volunteers. Psychopharmacology, Vol. 232, Issue. 9, p. 1607.
    Matsuzawa, Daisuke Shirayama, Yukihiko Niitsu, Tomihisa Hashimoto, Kenji and Iyo, Masaomi 2015. Deficits in emotion based decision-making in schizophrenia; a new insight based on the Iowa Gambling Task. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 57, Issue. , p. 52.
    Ogino, Shin Miyamoto, Seiya Miyake, Nobumi and Yamaguchi, Noboru 2014. Benefits and limits of anticholinergic use in schizophrenia: Focusing on its effect on cognitive function. Psychiatry and Clinical Neurosciences, Vol. 68, Issue. 1, p. 37.
    Gieling, Elise Wehkamp, Welmoed Willigenburg, Remco Nordquist, Rebecca E Ganderup, Niels-Christian and van der Staay, Franz Josef 2013. Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden. Behavioral and Brain Functions, Vol. 9, Issue. 1, p. 4.
    Kitajima, Rei Miyamoto, Seiya Tenjin, Tomomi Ojima, Kazuaki Ogino, Shin Miyake, Nobumi Fujiwara, Keisuke Funamoto, Yasuyuki Arai, Jun Tsukahara, Sachiko Ito, Yukie Tadokoro, Masanori Anai, Kiriko Kaneda, Yasuhiro and Yamaguchi, Noboru 2012. Effects of tapering of long-term benzodiazepines on cognitive function in patients with schizophrenia receiving a second-generation antipsychotic. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 36, Issue. 2, p. 300.
    Grootens, K. P. van Veelen, N. M. J. Peuskens, J. Sabbe, B. G. C. Thys, E. Buitelaar, J. K. Verkes, R. J. and Kahn, R. S. 2011. Ziprasidone Vs Olanzapine in Recent-Onset Schizophrenia and Schizoaffective Disorder: Results of an 8-Week Double-Blind Randomized Controlled Trial. Schizophrenia Bulletin, Vol. 37, Issue. 2, p. 352.
    Ogino, Shin Miyamoto, Seiya Tenjin, Tomomi Kitajima, Rei Ojima, Kazuaki Miyake, Nobumi Funamoto, Yasuyuki Arai, Jun Tsukahara, Sachiko Ito, Yukie Tadokoro, Masanori Anai, Kiriko Tatsunami, Shinobu Kubota, Hiroshi Kaneda, Yasuhiro and Yamaguchi, Noboru 2011. Effects of discontinuation of long-term biperiden use on cognitive function and quality of life in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 35, Issue. 1, p. 78.
    van Veelen, Nicoletta M.J. Grootens, Koen. P. Peuskens, J. Sabbe, B.G.C. Salden, Miriam E. Verkes, R.J. Kahn, René S. and Sitskoorn, Margriet M. 2010. Short term neurocognitive effects of treatment with ziprasidone and olanzapine in recent onset schizophrenia. Schizophrenia Research, Vol. 120, Issue. 1-3, p. 191.
    Shirayama, Yukihiko Obata, Takayuki Matsuzawa, Daisuke Nonaka, Hiroi Kanazawa, Yoko Yoshitome, Eiji Ikehira, Hiroo Hashimoto, Kenji and Iyo, Masaomi 2010. Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: A preliminary study. NeuroImage, Vol. 49, Issue. 3, p. 2783.
    Brébion, Gildas Bressan, Rodrigo A. David, Anthony S. and Pilowsky, Lyn S. 2009. Role of processing speed and premorbid IQ on visual recognition in patients with schizophrenia. Journal of Clinical and Experimental Neuropsychology, Vol. 31, Issue. 3, p. 302.
    Silver, Henry Goodman, Craig Isakov, Victoria Knoll, Gabriela and Modai, Ilan 2005. A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients. International Clinical Psychopharmacology, Vol. 20, Issue. 6, p. 319.
    Myers, Todd M. Galbicka, Gregory Sipos, Maurice L. Varadi, Suzanne Oubre, John L. and Clark, Matthew G. 2002. Effects of anticholinergics on serial-probe recognition accuracy of rhesus macaques (Macaca mulatta). Pharmacology Biochemistry and Behavior, Vol. 73, Issue. 4, p. 829.
    Silver, Henry and Shlomo, Nili 2001. Perception of facial emotions in chronic schizophrenia does not correlate with negative symptoms but correlates with cognitive and motor dysfunction. Schizophrenia Research, Vol. 52, Issue. 3, p. 265.
    Kimura, Yasuhiro Ohue, Mika Kitaura, Teruaki and Kihira, Kenji 1999. Amnesic effects of the anticholinergic drugs, trihexyphenidyl and biperiden: differences in binding properties to the brain muscarinic receptor. Brain Research, Vol. 834, Issue. 1-2, p. 6.
    Silver, Henry and Geraisy, Nabil 1996. Amantadine Does not Exacerbate Positive Symptoms in Medicated, Chronic Schizophrenic Patients. Journal of Clinical Psychopharmacology, Vol. 16, Issue. 6, p. 463.
    Albus, M. Hubmann, W. Wahlheim, C. Sobizack, N. Franz, U. and Mohr, F. 1996. Contrasts in neuropsychological test profile between patients with first-eoisode schizophienia and first-episohe affective disorders. Acta Psychiatrica Scandinavica, Vol. 94, Issue. 2, p. 87.
    SILVER, HENRY and GERAISY, NABIL 1996. On Prescribing an Antiparkinsonian Drug. Human Psychopharmacology: Clinical and Experimental, Vol. 11, Issue. 6, p. 517.
    Silver, Henry and Geraisy, Nabil 1995. No difference in the effect of biperiden and amantadine on negative symptoms in medicated chronic schizophrenic patients. Biological Psychiatry, Vol. 38, Issue. 6, p. 413.
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Effects of Biperiden and Amantadine on Memory in Medicated Chronic Schizophrenic Patients: A Double-blind Cross-over Study

  • H. Silver (a1) and N. Geraisy (a1)
Abstract
Background

The effects on memory of an anticholinergic (biperiden) and a dopaminergic (amantadine) anti-Parkinsonian agent were compared.

 Method

Twenty-six chronically medicated schizophrenic (DSM–III–R) in-patients received amantadine (200 mg/day) or biperiden (4 mg/day) for two weeks in a double-blind cross-over design.

 Results

Biperiden treatment was associated with significantly lower scores on Benton Visual Retention Test (P < 0.003) and the visual subscale of Wechsler Memory Scale (WMS) (P ≤ 0.02), with a trend to poorer scores on WMS total (P = 0.086) and the digit span (P = 0.07) and logical memory (P = 0.06) subscales.

 Conclusions

In usual clinical doses, biperiden interferes with memory, particularly visual, more than amantadine.
Copyright
COPYRIGHT: © 1995 The Royal College of Psychiatrists 
Corresponding author
Dr H. Silver, Flugelman (Mazra) Psychiatric Hospital, Doar Na Ashrat, Israel
References
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American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.
Caley, A. (1983) Anticholinergic drugs and memory. British Journal of Psychiatry, 143, 422–423.
Fayen, M., Goldman, M. B., Moulthrop, M. A., et al (1988) Differential memory function with dopaminergic versus anticholinergic treatment of drug induced extrapyramidal symptoms. American Journal of Psychiatry, 145, 483–486.
Gelenberg, A. J., Van Putten, T., Lavori, P. W. W., et al (1989) Anticholinergic effects on memory: benztropine versus amantadine. Journal of Clinical Psychopharmacology, 9, 180–185.
Green, M. & Walker, E. (1986) Attentional performance in positive and negative symptom schizophrenia. Journal of Nervous and Mental Disease, 174, 208–213.
King, D. J. (1990) The effect of neuroleptics on cognitive and psychomotor function. British Journal of Psychiatry, 157, 799–811.
Lezak, M. D. (1983) Neuropsychological Assessment (2nd edn). Oxford: Oxford University Press.
McEvoy, J. P. (1987) A double-blind crossover comparison of antiparkinsonian drug therapy: amantadine versus anticholinergics in 90 normal volunteers, with an emphasis on differential effects on memory function. Journal of Clinical Psychiatry, 48 (suppl. 9), 20–23.
Patamianos, G. & Kellett, J. M. (1982) Anticholinergic drugs and memory. The effects of benzhexol on memory in a group of geriatric patients. British Journal of Psychiatry, 140, 470–472.
Saykin, A. J., Gur, R. C., Gur, R. E., et al (1991) Neuropsychological function in schizophrenia. Selective impairment in memory and learning. Archives of General Psychiatry, 48, 618–624.
Tamlyn, D., McKenna, R. J., Mortimer, A. M., et al (1992) Memory impairment in schizophrenia: its extent, affiliations and neuropsychological character. Psychological Medicine, 22, 101–115.
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  • EISSN: 1472-1465
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  • Cited by 18
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Veselinović, Tanja Vernaleken, Ingo Janouschek, Hildegard Kellermann, Thilo Paulzen, Michael Cumming, Paul and Gründer, Gerhard 2015. Effects of anticholinergic challenge on psychopathology and cognition in drug-free patients with schizophrenia and healthy volunteers. Psychopharmacology, Vol. 232, Issue. 9, p. 1607.
    Matsuzawa, Daisuke Shirayama, Yukihiko Niitsu, Tomihisa Hashimoto, Kenji and Iyo, Masaomi 2015. Deficits in emotion based decision-making in schizophrenia; a new insight based on the Iowa Gambling Task. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 57, Issue. , p. 52.
    Ogino, Shin Miyamoto, Seiya Miyake, Nobumi and Yamaguchi, Noboru 2014. Benefits and limits of anticholinergic use in schizophrenia: Focusing on its effect on cognitive function. Psychiatry and Clinical Neurosciences, Vol. 68, Issue. 1, p. 37.
    Gieling, Elise Wehkamp, Welmoed Willigenburg, Remco Nordquist, Rebecca E Ganderup, Niels-Christian and van der Staay, Franz Josef 2013. Performance of conventional pigs and Göttingen miniature pigs in a spatial holeboard task: effects of the putative muscarinic cognition impairer Biperiden. Behavioral and Brain Functions, Vol. 9, Issue. 1, p. 4.
    Kitajima, Rei Miyamoto, Seiya Tenjin, Tomomi Ojima, Kazuaki Ogino, Shin Miyake, Nobumi Fujiwara, Keisuke Funamoto, Yasuyuki Arai, Jun Tsukahara, Sachiko Ito, Yukie Tadokoro, Masanori Anai, Kiriko Kaneda, Yasuhiro and Yamaguchi, Noboru 2012. Effects of tapering of long-term benzodiazepines on cognitive function in patients with schizophrenia receiving a second-generation antipsychotic. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 36, Issue. 2, p. 300.
    Grootens, K. P. van Veelen, N. M. J. Peuskens, J. Sabbe, B. G. C. Thys, E. Buitelaar, J. K. Verkes, R. J. and Kahn, R. S. 2011. Ziprasidone Vs Olanzapine in Recent-Onset Schizophrenia and Schizoaffective Disorder: Results of an 8-Week Double-Blind Randomized Controlled Trial. Schizophrenia Bulletin, Vol. 37, Issue. 2, p. 352.
    Ogino, Shin Miyamoto, Seiya Tenjin, Tomomi Kitajima, Rei Ojima, Kazuaki Miyake, Nobumi Funamoto, Yasuyuki Arai, Jun Tsukahara, Sachiko Ito, Yukie Tadokoro, Masanori Anai, Kiriko Tatsunami, Shinobu Kubota, Hiroshi Kaneda, Yasuhiro and Yamaguchi, Noboru 2011. Effects of discontinuation of long-term biperiden use on cognitive function and quality of life in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 35, Issue. 1, p. 78.
    van Veelen, Nicoletta M.J. Grootens, Koen. P. Peuskens, J. Sabbe, B.G.C. Salden, Miriam E. Verkes, R.J. Kahn, René S. and Sitskoorn, Margriet M. 2010. Short term neurocognitive effects of treatment with ziprasidone and olanzapine in recent onset schizophrenia. Schizophrenia Research, Vol. 120, Issue. 1-3, p. 191.
    Shirayama, Yukihiko Obata, Takayuki Matsuzawa, Daisuke Nonaka, Hiroi Kanazawa, Yoko Yoshitome, Eiji Ikehira, Hiroo Hashimoto, Kenji and Iyo, Masaomi 2010. Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: A preliminary study. NeuroImage, Vol. 49, Issue. 3, p. 2783.
    Brébion, Gildas Bressan, Rodrigo A. David, Anthony S. and Pilowsky, Lyn S. 2009. Role of processing speed and premorbid IQ on visual recognition in patients with schizophrenia. Journal of Clinical and Experimental Neuropsychology, Vol. 31, Issue. 3, p. 302.
    Silver, Henry Goodman, Craig Isakov, Victoria Knoll, Gabriela and Modai, Ilan 2005. A double-blind, cross-over comparison of the effects of amantadine or placebo on visuomotor and cognitive function in medicated schizophrenia patients. International Clinical Psychopharmacology, Vol. 20, Issue. 6, p. 319.
    Myers, Todd M. Galbicka, Gregory Sipos, Maurice L. Varadi, Suzanne Oubre, John L. and Clark, Matthew G. 2002. Effects of anticholinergics on serial-probe recognition accuracy of rhesus macaques (Macaca mulatta). Pharmacology Biochemistry and Behavior, Vol. 73, Issue. 4, p. 829.
    Silver, Henry and Shlomo, Nili 2001. Perception of facial emotions in chronic schizophrenia does not correlate with negative symptoms but correlates with cognitive and motor dysfunction. Schizophrenia Research, Vol. 52, Issue. 3, p. 265.
    Kimura, Yasuhiro Ohue, Mika Kitaura, Teruaki and Kihira, Kenji 1999. Amnesic effects of the anticholinergic drugs, trihexyphenidyl and biperiden: differences in binding properties to the brain muscarinic receptor. Brain Research, Vol. 834, Issue. 1-2, p. 6.
    Silver, Henry and Geraisy, Nabil 1996. Amantadine Does not Exacerbate Positive Symptoms in Medicated, Chronic Schizophrenic Patients. Journal of Clinical Psychopharmacology, Vol. 16, Issue. 6, p. 463.
    Albus, M. Hubmann, W. Wahlheim, C. Sobizack, N. Franz, U. and Mohr, F. 1996. Contrasts in neuropsychological test profile between patients with first-eoisode schizophienia and first-episohe affective disorders. Acta Psychiatrica Scandinavica, Vol. 94, Issue. 2, p. 87.
    SILVER, HENRY and GERAISY, NABIL 1996. On Prescribing an Antiparkinsonian Drug. Human Psychopharmacology: Clinical and Experimental, Vol. 11, Issue. 6, p. 517.
    Silver, Henry and Geraisy, Nabil 1995. No difference in the effect of biperiden and amantadine on negative symptoms in medicated chronic schizophrenic patients. Biological Psychiatry, Vol. 38, Issue. 6, p. 413.
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  • Get access
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Effects of Biperiden and Amantadine on Memory in Medicated Chronic Schizophrenic Patients: A Double-blind Cross-over Study

  • H. Silver (a1) and N. Geraisy (a1)
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