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  • Cited by 25
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Lai, Chien-Han 2018. The neural markers of MRI to differentiate depression and panic disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry,
    Zhang, Fei-Fei Peng, Wei Sweeney, John A. Jia, Zhi-Yun and Gong, Qi-Yong 2018. Brain structure alterations in depression: Psychoradiological evidence. CNS Neuroscience & Therapeutics,
    Martínez-Amorós, Erika Goldberg, Ximena Gálvez, Verònica de Arriba- Arnau, Aida Soria, Virginia Menchón, José M. Palao, Diego J. Urretavizcaya, Mikel and Cardoner, Narcís 2018. Early improvement as a predictor of final remission in major depressive disorder: New insights in electroconvulsive therapy. Journal of Affective Disorders, Vol. 235, Issue. , p. 169.
    Morris, Gerwyn Berk, Michael and Puri, Basant K. 2018. A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?. Molecular Neurobiology, Vol. 55, Issue. 4, p. 3592.
    Dusi, Nicola Delvecchio, Giuseppe Rovera, Chiara Altamura, Carlo A. and Brambilla, Paolo 2018. Brain Morphometry. Vol. 136, Issue. , p. 385.
    Yang, Shuran Cheng, Yuqi Mo, Yin Bai, Yan Shen, Zonglin Liu, Fang Li, Na Jiang, Linling Chen, Wei Lu, Yi Sun, Xuejin and Xu, Xiufeng 2017. Childhood maltreatment is associated with gray matter volume abnormalities in patients with first-episode depression. Psychiatry Research: Neuroimaging, Vol. 268, Issue. , p. 27.
    Liu, Jia Xu, Xin Luo, Qiang Luo, Ya Chen, Ying Lui, Su Wu, Min Zhu, Hongyan Kemp, Graham J. and Gong, Qiyong 2017. Brain grey matter volume alterations associated with antidepressant response in major depressive disorder. Scientific Reports, Vol. 7, Issue. 1,
    Laux, Gerd 2017. Psychiatrie, Psychosomatik, Psychotherapie. p. 1711.
    Qin, Jiaolong Liu, Haiyan Wei, Maobin Zhao, Ke Chen, Jianhuai Zhu, Jingyu Shen, Xiangyu Yan, Rui Yao, Zhijian and Lu, Qing 2017. Reconfiguration of hub-level community structure in depressions: A follow-up study via diffusion tensor imaging. Journal of Affective Disorders, Vol. 207, Issue. , p. 305.
    Wu, Guo-Rong and Baeken, Chris 2017. Longer depressive episode duration negatively influences HF-rTMS treatment response: a cerebellar metabolic deficiency?. Brain Imaging and Behavior, Vol. 11, Issue. 1, p. 8.
    Serra-Blasco, Maria de Diego-Adeliño, Javier Vives-Gilabert, Yolanda Trujols, Joan Puigdemont, Dolors Carceller-Sindreu, Mar Pérez, Victor Álvarez, Enric and Portella, Maria J. 2016. NATURALISTIC COURSE OF MAJOR DEPRESSIVE DISORDER PREDICTED BY CLINICAL AND STRUCTURAL NEUROIMAGING DATA: A 5-YEAR FOLLOW-UP. Depression and Anxiety, Vol. 33, Issue. 11, p. 1055.
    Lu, Yi Liang, Hongmin Han, Dan Mo, Yin Li, Zongfang Cheng, Yuqi Xu, Xiufeng Shen, Zonglin Tan, Chunyan Zhao, Wei Zhu, Yun and Sun, Xuejin 2016. The volumetric and shape changes of the putamen and thalamus in first episode, untreated major depressive disorder. NeuroImage: Clinical, Vol. 11, Issue. , p. 658.
    Zhang, Huawei Li, Lei Wu, Min Chen, Ziqi Hu, Xinyu Chen, Ying Zhu, Hongyan Jia, Zhiyun and Gong, Qiyong 2016. Brain gray matter alterations in first episodes of depression: A meta-analysis of whole-brain studies. Neuroscience & Biobehavioral Reviews, Vol. 60, Issue. , p. 43.
    Laux, Gerd 2016. Psychiatrie, Psychosomatik, Psychotherapie. p. 1.
    Schwab, Nadine A. Tanner, Jared J. Nguyen, Peter T. Schmalfuss, Ilona M. Bowers, Dawn Okun, Michael and Price, Catherine C. 2015. Proof of principle: Transformation approach alters caudate nucleus volume and structure-function associations. Brain Imaging and Behavior, Vol. 9, Issue. 4, p. 744.
    Tang, Juanjuan Xue, Wenda Xia, Baomei Ren, Li Tao, Weiwei Chen, Chang Zhang, Hailou Wu, Ruyan Wang, Qisheng Wu, Haoxin Duan, Jinao and Chen, Gang 2015. Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice. Scientific Reports, Vol. 5, Issue. 1,
    Carceller-Sindreu, M. de Diego-Adeliño, J. Serra-Blasco, M. Vives-Gilabert, Y. Martí;n-Blanco, A. Puigdemont, D. Álvarez, E. Pérez, V. and Portella, M.J. 2015. Volumetric MRI study of the habenula in first episode, recurrent and chronic major depression. European Neuropsychopharmacology, Vol. 25, Issue. 11, p. 2015.
    Lai, Chien-Han and Wu, Yu-Te 2015. The gray matter alterations in major depressive disorder and panic disorder: Putative differences in the pathogenesis. Journal of Affective Disorders, Vol. 186, Issue. , p. 1.
    Opel, Nils Redlich, Ronny Grotegerd, Dominik Dohm, Katharina Heindel, Walter Kugel, Harald Arolt, Volker and Dannlowski, Udo 2015. Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations. Psychoneuroendocrinology, Vol. 51, Issue. , p. 219.
    Lai, Chien-Han and Wu, Yu-Te 2014. Frontal-insula gray matter deficits in first-episode medication-naïve patients with major depressive disorder. Journal of Affective Disorders, Vol. 160, Issue. , p. 74.
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Effects of illness duration and treatment resistance on grey matter abnormalities in majordepression

  • Maria Serra-Blasco (a1), Maria J. Portella (a2), Beatriz Gómez-Ansón (a3), Javier de Diego-Adeliño (a2), Yolanda Vives-Gilabert (a4), Dolors Puigdemont (a2), Ester Granell (a5), Alicia Santos (a6), Enric Álvarez (a7) and Víctor Pérez (a7)...
Abstract
Background

Findings of brain structural changes in major depressive disorder are still inconsistent, partly because some crucial clinical variables have not been taken into account.

Aims

To investigate the effect of major depressive disorder on grey matter volumes.

Method

Voxel-based morphometry was used to compare 66 patients with depression at different illness stages (22 each with first-episode, remitted-recurrent and treatment resistant/chronic depression) with 32 healthy controls. Brain volumes were correlated with clinical variables.

Results

Voxel-based morphometry showed a significant group effect in right superior frontal gyrus, left medial frontal gyrus and left cingulate gyrus (P<0.05, family wise error-corrected). Patients whose condition was treatment resistant/chronic exhibited the smallest volumes in frontotemporal areas. Longer illness duration was negatively correlated with decreases in right medial frontal cortex and left insula.

Conclusions

Frontotemporolimbic areas are smaller in the patients with severe depression and are associated with duration of illness, but not with medication patterns, suggesting negative effects of long-lasting major depressive disorder on grey matter.

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Copyright
COPYRIGHT: © Royal College of Psychiatrists, 2013 
Corresponding author
Maria J. Portella, Department of Psychiatry, Hospital de la Santa Creu i Sant Pau, Institut d'Investigacions Biomédiques de Sant Pau (IIB-Sant Pau); Centro deInvestigación Biomedica en Red de Salud Mental (CIBERSAM), Sant Antoni Ma. Claret 167, 08025 Barcelona, Catalonia, Spain. Email: MPortella@santpau.cat
Footnotes
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Declaration of interest

V.P. has received educational honoraria from: Sanofi-Aventis, Lundbeck, Pfizer, AstraZeneca and Eli Lilly, and research funding from Boehringer-Ingelheim for this work. E.A. has received consulting and educational honoraria from several pharmaceutical companies including Eli Lilly, Sanofi-Aventis, Lundbeck and Pfizer, and he has participated as main local investigator in clinical trials from Eli Lilly, Bristol-Myers Squibb and Sanofi-Aventis and also as national coordinator of clinical trials from Servier and Lundbeck.

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References
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  • Cited by 25
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Lai, Chien-Han 2018. The neural markers of MRI to differentiate depression and panic disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry,
    Zhang, Fei-Fei Peng, Wei Sweeney, John A. Jia, Zhi-Yun and Gong, Qi-Yong 2018. Brain structure alterations in depression: Psychoradiological evidence. CNS Neuroscience & Therapeutics,
    Martínez-Amorós, Erika Goldberg, Ximena Gálvez, Verònica de Arriba- Arnau, Aida Soria, Virginia Menchón, José M. Palao, Diego J. Urretavizcaya, Mikel and Cardoner, Narcís 2018. Early improvement as a predictor of final remission in major depressive disorder: New insights in electroconvulsive therapy. Journal of Affective Disorders, Vol. 235, Issue. , p. 169.
    Morris, Gerwyn Berk, Michael and Puri, Basant K. 2018. A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?. Molecular Neurobiology, Vol. 55, Issue. 4, p. 3592.
    Dusi, Nicola Delvecchio, Giuseppe Rovera, Chiara Altamura, Carlo A. and Brambilla, Paolo 2018. Brain Morphometry. Vol. 136, Issue. , p. 385.
    Yang, Shuran Cheng, Yuqi Mo, Yin Bai, Yan Shen, Zonglin Liu, Fang Li, Na Jiang, Linling Chen, Wei Lu, Yi Sun, Xuejin and Xu, Xiufeng 2017. Childhood maltreatment is associated with gray matter volume abnormalities in patients with first-episode depression. Psychiatry Research: Neuroimaging, Vol. 268, Issue. , p. 27.
    Liu, Jia Xu, Xin Luo, Qiang Luo, Ya Chen, Ying Lui, Su Wu, Min Zhu, Hongyan Kemp, Graham J. and Gong, Qiyong 2017. Brain grey matter volume alterations associated with antidepressant response in major depressive disorder. Scientific Reports, Vol. 7, Issue. 1,
    Laux, Gerd 2017. Psychiatrie, Psychosomatik, Psychotherapie. p. 1711.
    Qin, Jiaolong Liu, Haiyan Wei, Maobin Zhao, Ke Chen, Jianhuai Zhu, Jingyu Shen, Xiangyu Yan, Rui Yao, Zhijian and Lu, Qing 2017. Reconfiguration of hub-level community structure in depressions: A follow-up study via diffusion tensor imaging. Journal of Affective Disorders, Vol. 207, Issue. , p. 305.
    Wu, Guo-Rong and Baeken, Chris 2017. Longer depressive episode duration negatively influences HF-rTMS treatment response: a cerebellar metabolic deficiency?. Brain Imaging and Behavior, Vol. 11, Issue. 1, p. 8.
    Serra-Blasco, Maria de Diego-Adeliño, Javier Vives-Gilabert, Yolanda Trujols, Joan Puigdemont, Dolors Carceller-Sindreu, Mar Pérez, Victor Álvarez, Enric and Portella, Maria J. 2016. NATURALISTIC COURSE OF MAJOR DEPRESSIVE DISORDER PREDICTED BY CLINICAL AND STRUCTURAL NEUROIMAGING DATA: A 5-YEAR FOLLOW-UP. Depression and Anxiety, Vol. 33, Issue. 11, p. 1055.
    Lu, Yi Liang, Hongmin Han, Dan Mo, Yin Li, Zongfang Cheng, Yuqi Xu, Xiufeng Shen, Zonglin Tan, Chunyan Zhao, Wei Zhu, Yun and Sun, Xuejin 2016. The volumetric and shape changes of the putamen and thalamus in first episode, untreated major depressive disorder. NeuroImage: Clinical, Vol. 11, Issue. , p. 658.
    Zhang, Huawei Li, Lei Wu, Min Chen, Ziqi Hu, Xinyu Chen, Ying Zhu, Hongyan Jia, Zhiyun and Gong, Qiyong 2016. Brain gray matter alterations in first episodes of depression: A meta-analysis of whole-brain studies. Neuroscience & Biobehavioral Reviews, Vol. 60, Issue. , p. 43.
    Laux, Gerd 2016. Psychiatrie, Psychosomatik, Psychotherapie. p. 1.
    Schwab, Nadine A. Tanner, Jared J. Nguyen, Peter T. Schmalfuss, Ilona M. Bowers, Dawn Okun, Michael and Price, Catherine C. 2015. Proof of principle: Transformation approach alters caudate nucleus volume and structure-function associations. Brain Imaging and Behavior, Vol. 9, Issue. 4, p. 744.
    Tang, Juanjuan Xue, Wenda Xia, Baomei Ren, Li Tao, Weiwei Chen, Chang Zhang, Hailou Wu, Ruyan Wang, Qisheng Wu, Haoxin Duan, Jinao and Chen, Gang 2015. Involvement of normalized NMDA receptor and mTOR-related signaling in rapid antidepressant effects of Yueju and ketamine on chronically stressed mice. Scientific Reports, Vol. 5, Issue. 1,
    Carceller-Sindreu, M. de Diego-Adeliño, J. Serra-Blasco, M. Vives-Gilabert, Y. Martí;n-Blanco, A. Puigdemont, D. Álvarez, E. Pérez, V. and Portella, M.J. 2015. Volumetric MRI study of the habenula in first episode, recurrent and chronic major depression. European Neuropsychopharmacology, Vol. 25, Issue. 11, p. 2015.
    Lai, Chien-Han and Wu, Yu-Te 2015. The gray matter alterations in major depressive disorder and panic disorder: Putative differences in the pathogenesis. Journal of Affective Disorders, Vol. 186, Issue. , p. 1.
    Opel, Nils Redlich, Ronny Grotegerd, Dominik Dohm, Katharina Heindel, Walter Kugel, Harald Arolt, Volker and Dannlowski, Udo 2015. Obesity and major depression: Body-mass index (BMI) is associated with a severe course of disease and specific neurostructural alterations. Psychoneuroendocrinology, Vol. 51, Issue. , p. 219.
    Lai, Chien-Han and Wu, Yu-Te 2014. Frontal-insula gray matter deficits in first-episode medication-naïve patients with major depressive disorder. Journal of Affective Disorders, Vol. 160, Issue. , p. 74.
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Effects of illness duration and treatment resistance on grey matter abnormalities in majordepression

  • Maria Serra-Blasco (a1), Maria J. Portella (a2), Beatriz Gómez-Ansón (a3), Javier de Diego-Adeliño (a2), Yolanda Vives-Gilabert (a4), Dolors Puigdemont (a2), Ester Granell (a5), Alicia Santos (a6), Enric Álvarez (a7) and Víctor Pérez (a7)...
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