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Folate Deficiency in Depressive Illness

  • E. H. Reynolds (a1), J. M. Preece (a2), J. Bailey (a3) and Alec Coppen (a4)

Two reports have shown that a substantial proportion of patients suffering from various psychiatric syndromes have low serum folate concentrations (Hunter, Jones Jones and Matthews, 1967; Carney, 1967). The present investigation was concerned to examine further the prevalence of low serum folate in a series of depressive patients on admission to hospital. As folate deficiency contributes to the development of mental symptoms in epileptic patients (Reynolds, 1968), we also examined the relationship of low serum folate concentrations to the severity of the depressive illness, certain personality traits, and the response to anti-depressant treatment. The relationship of low serum folate to variables which could influence it such as diet and drugs was also examined. In a proportion of these patients serum folate measurements were repeated just before the patient's discharge. Serum B12 concentrations were also estimated.

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Baker, H., Herbert, V., Frank, O., Pasher, I., Hutner, S. H., Wasserman, L. R., and Sobotka, H. (1959). ‘A microbiologic method for detecting folic acid deficiency in man.’ Clin, Chem., 5, 275–80.
Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., Erbaugh, J. (1961). ‘An inventory for measuring depression.’ Arch. gen. Psychiat., 4, 561–71.
Carney, M. W. P. (1967). ‘Serum folate values in 423 psychiatric patients.’ Brit. med. J., 4, 512–16.
Coppen, A., and Metcalfe, M. (1965). ‘Effect of a depressive illness on M.P.I. scores.’ Brit. J. Psychiat., 3, 236–9.
Coppen, A. (1966). ‘The Marke-Nyman temperament scale: an English translation.’ Brit. J. med. Psychol., 39, 5559.
Coppen, A. (1968). ‘Depressed states and indolealkylamines.’ Advances in Pharmacology, 6, 283–91.
Coppen, A., Shaw, D. M., Herzberg, B., and Maggs, R. (1967). ‘Tryptophan in the treatment of depression.’ Lancet, ii, 1178–80.
Edwin, E., Holten, K., Norum, K. R., Schrumpf, A., and Skaug, O. E. (1965). ‘Vitamin B12 hypovitaminosis in mental diseases.’ Acta med. Scand., 177, 689–99.
Eysenck, H. J., and Eysenck, S. B. G. (1964). Manual of the Eysenck Personality Inventory. London.
Girdwood, R. H., Thomson, A. D., and Williamson, J. (1967). ‘Folate status in the elderly.’ Brit. med. J., ii, 670–2.
Henderson, J. G., Strachan, R. W., Beck, J. S., Dawson, A., and Daniel, M. (1966). ‘The antigastric-antibody test as a screening procedure for vitamin B12 deficiency in psychiatric practice.’ Lancet, ii, 809–13.
Hunter, R., Jones, M., Jones, T. G., and Matthews, D. M. (1967). ‘Serum B12 and folate concentrations in mental patients.’ Brit. J. Psychiat., 113, 1291–5.
Lovenberg, W., Jequire, E., and Sjoerdsma, A. (1968). ‘Tryptophan hydroxylation in mammalian systems.’ Advances in Pharmacology, 6, 2136.
Metcalfe, M., and Goldman, E. (1965). ‘Validation of an inventory for measuring depression.’ Brit. J. Psychiat., 111, 240–2.
Reynolds, E. H., Chanarin, I., Milner, G., and Matthews, D. M. (1966). ‘Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms.’ Epilepsia, 7, 261–70.
Reynolds, E. H. (1967a). ‘Effects of folic acid on the mental state and fit frequency of drug-treated epileptic patients.’ Lancet, i, 1086–8.
Reynolds, E. H. (1967b). ‘Vitamin B12 and folate deficiencies.’ Brit. J. Psychiat., 113, 681–3.
Reynolds, E. H. (1968). ‘Mental effects of anticonvulsants and folate metabolism.’ Brain, 91, 197214.
Schildkraut, J. J. (1965). ‘The catecholamine hypothesis of affective disorders: a review of supporting evidence.’ Amer. J. Psychiat., 122, 509–22.
Udenfriend, S. (1966). ‘Biosynthesis of the sympathetic neurotransmitter, norepinephrine.’ The Harvey Lectures, Series 60, 5783.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Folate Deficiency in Depressive Illness

  • E. H. Reynolds (a1), J. M. Preece (a2), J. Bailey (a3) and Alec Coppen (a4)
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