Skip to main content
×
×
Home

Generic clozapine: outcomes after switching formulations

  • Carol Paton (a1)
Summary

Two generic preparations of clozapine have been licensed in the UK. The bioequivalence of these products compared with Clozaril® has not been unequivocally demonstrated. Clinical equivalence has also been questioned. The objective of this study was to determine clinical outcomes for all patients switched from Clozaril® to a generic formulation in one mental health service. We examined dosage data and Clinical Global Impression (CGI) of Severity of Illness scores for 337 patients before and after the switch and CGI change scores after the switch. There was no evidence of clinical deterioration or need to use higher dosages. Generic clozapine is not inferior to Clozaril®.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Generic clozapine: outcomes after switching formulations
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Generic clozapine: outcomes after switching formulations
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Generic clozapine: outcomes after switching formulations
      Available formats
      ×
Copyright
References
Hide All
Anon (2001) Comparison of the bioequivalence of generic versus branded clozapine. Journal of Clinical Psychiatry, 62 (suppl. 5), 2324.
Ereshefsky, L. & Glazer, W. M. (2001) Comparison of the bioequivalence of generic versus branded clozapine. Journal of Clinical Psychiatry, 62 (suppl. 5), 2528.
Guy, W. (ed.) (1976) ECDEU Assessment Manual for Psychopharmacology: Publication ADM 76-338, pp. 217222. Rockville, MD: US Department of Health, Education and Welfare.
Kluznik, J. C., Walbek, N. H., Farnsworth, M. G., et al (2001) Clinical effects of a randomised switch of patients from Clozaril to a generic clozapine. Journal of Clinical Psychiatry, 62 (suppl. 5), 1417.
Lam, Y. W., Ereshefsky, L., Toney, G. B., et al (2001) Branded versus generic clozapine: bioavailability comparison and interchangeability issues. Journal of Clinical Psychiatry, 62 (suppl. 5), 1822.
Makela, E. H., Cutlip, W. D., Stevenson, J. M., et al (2003) Branded versus generic clozapine for treatment of schizophrenia. Annals of Pharmacotherapy, 37, 350353.
Mofsen, R. & Balter, J. (2001) Case reports of the re-emergence of psychotic symptoms after conversion from brand name clozapine to a generic formulation. Clinical Therapeutics, 23, 17201731.
National Institute for Clinical Excellence (2003) Atypical Antipsychotics in the Treatment of Schizophrenia. Health Technology Appraisal No 43. London: National Institute for Clinical Excellence.
Sajbel, T. A., Carter, G. W. & Wiley, R. B. (2001) Converting patients from brand-name clozapine to generic clozapine. Annals of Pharmacotherapy, 35, 281284.
Stoner, S. C., Lea, J. W., Dubisar, B., et al (2003) A program to convert patients from trade-name to generic clozapine. Pharmacotherapy, 23, 806810.
Wahlbeck, K., Cheine, M. & Essali, M. A. (1999) Clozapine versus typical neuroleptic medication for schizophrenia. The Cochrane Database of Systematic Reviews. Issue 4 (accessed August 2005). Oxford: Update Software.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 17 *
Loading metrics...

Abstract views

Total abstract views: 119 *
Loading metrics...

* Views captured on Cambridge Core between 2nd January 2018 - 25th June 2018. This data will be updated every 24 hours.

Generic clozapine: outcomes after switching formulations

  • Carol Paton (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *