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A Genetic Study of Affective Illness in Patients over 50

  • G. Hopkinson (a1)
Extract

The genetic evidence concerning affective illness of later life is still conflicting and the relationship of such conditions to the manic-depressive psychosis unclear. Kallman (1955) believed that, genetically, involutional melancholia bore a closer relationship to schizophrenia than to the manic-depressive psychosis. An increased risk for schizophrenia amongst the relatives of such patients was not observed by Kay (1959) and Stenstedt (1952). Both these writers do however describe a lower loading for manic-depressive psychosis than would be found amongst the relations of manic-depressive patients, though a much higher incidence than in the general population. Both Stenstedt and Kay assumed that they were dealing with a heterogeneous group of patients containing both psychotic and neurotic depressions.

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Kallman, F. J. (1953). Heredity in Health and Mental Disorder. New York: Norton.
Kallman, F. J. and Barroff, L. (1955). “Abnormalities of behaviour (in the light of psychogenetic studies)”, Ann. Rev. Psychol., 6, 297.
Kay, D. (1959). “Observations on the natural history and genetics of old age psychoses”, Proc. Roy. Soc. Med., 52, 791.
Petrilowitsch, N., and Heinrich, K. (1961). “Zur klinischen Differenzierung endogen-depressiver Erkrankungen”, Z. ges. Neurol. Psychiat., 202, 371.
Schulz, B. (1951). “Auszahlungen in der Verwandtschaft von nach Erkrankungsalter und Geschlecht gruppierten Manisch-depressiven”, Arch. f. Psych, u. Z. Neurol., 186, 560.
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Stenstedt, A. (1952). “A study in manic-depressive psychosis: clinical, social and genetic investigations”, Acta psychiat. Scand. Suppl. 79.
Stenstedt, A. “Involutional melancholia: an aetiologic, clinical and social study of endogenous depression in later life, with special reference to genetic factors”, ibid., 127.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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A Genetic Study of Affective Illness in Patients over 50

  • G. Hopkinson (a1)
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