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Genome-wide association studies in psychiatry: what have we learned?

  • Ann L. Collins (a1) and Patrick F. Sullivan (a1)
Summary

Genome-wide association studies (GWAS) have been the focus of considerable effort in psychiatry. These efforts have markedly increased knowledge of the genetic basis of psychiatric disorders, and yielded empirical data on genetic architecture critical to addressing long-standing debates in the field. There is a now a clear path to increased knowledge of the ‘parts lists’ for these disorders.

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Copyright
Corresponding author
Patrick F. Sullivan, Department of Genetics, CB#7264, 5097 Genomic Medicine Building, University of North Carolina, Chapel Hill, NC 27599-7264, USA. Email: pfsulliv@med.unc.edu
References
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1 Corvin, A, Craddock, N, Sullivan, PF. Genome-wide association studies: a primer. Psychol Med 2010; 40: 1063–77.
2 National Human Genome Reseach Institute. A Catalog of Published Genome-Wide Association Studies. National Human Genome Reseach Institute, no date (http://www.genome.gov/26525384).
3 Psychiatric GWAS Consortium. A framework for interpreting genomewide association studies of psychiatric disorders. Mol Psychiatry 2009; 14: 10–7.
4 Sullivan, P, de Geus, E, Willemsen, G, James, MR, Smit, JH, Zandbelt, T, et al Genomewide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry 2009; 14: 359–75.
5 Major Depressive Disorder Working Group of the PGC. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry 2012; April 3 (Epub ahead of print).
6 Sullivan, PF, Daly, MJ, O'Donovan, M. Genetic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet 2012; 13: 537–51.
7 Collins, AL, Kim, Y, Sklar, P, O'Donovan, MC, Sullivan, PF. Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. Psychol Med 2012; 42: 607–16.
8 Visscher, PM, Brown, MA, McCarthy, MI, Yang, J. Five years of GWAS discovery. Am J Hum Genet 2012; 90: 724.
9 Sullivan, PF. Schizophrenia as a pathway disease. Nat Med 2012; 18: 210–1.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Genome-wide association studies in psychiatry: what have we learned?

  • Ann L. Collins (a1) and Patrick F. Sullivan (a1)
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