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Handedness, language lateralisation and anatomical asymmetry in schizophrenia: Meta-analysis

  • Iris Sommer (a1), André Aleman (a2), Nick Ramsey (a1), Anke Bouma (a3) and René Kahn (a1)...

Abstract

Background

Cerebral lateralisation appears to be decreased in schizophrenia. Results of studies investigating this, however, are equivocal.

Aims

To review quantitatively the literature on decreased lateralisation in schizophrenia.

Method

Meta-analyses were conducted on 19 studies on handedness, 10 dichotic listening studies and 39 studies investigating anatomical asymmetry in schizophrenia.

Results

The prevalence of mixed- and left-handedness (‘non-right-handedness’) was significantly higher in patients with schizophrenia as compared to healthy controls, and also as compared to psychiatric controls. The analysis of dichotic listening studies revealed no significant difference in lateralisation in schizophrenia. However, when analysis was restricted to studies using consonant-vowel or fused word tasks, significantly decreased lateralisation in schizophrenia emerged. Asymmetry of the planum temporale and the Sylvian fissure was significantly decreased in schizophrenia, while asymmetry of the temporal horn of the lateral ventricle was not.

Conclusion

Strong evidence is provided for decreased cerebral lateralisation in schizophrenia.

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Copyright

Corresponding author

Iris Sommer, Department of Psychiatry, University Medical Centre Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands. Tel: + + 31 30 2508352; fax: ++31 302505443; e-mail: I.Sommer@AZU.nl

Footnotes

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Declaration of interest

None

Footnotes

References

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Handedness, language lateralisation and anatomical asymmetry in schizophrenia: Meta-analysis

  • Iris Sommer (a1), André Aleman (a2), Nick Ramsey (a1), Anke Bouma (a3) and René Kahn (a1)...
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