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I. Rationale and methods

  • Robert M. Post (a1), Kirk D. Denicoff (a1), Gabriele S. Leverich (a1), Willem A. Nolen (a2), Ralph W. Kupka (a2), Paul E. Keck (a3), Susan L. McElroy (a3), A. John Rush (a4), Trisha Suppes (a4), Lori L. Altshuler (a5), Mark A. Frye (a5), Heinz Grunze (a6) and Jörg Walden (a7)...
Abstract
Background

The Stanley Foundation Bipolar Network (SFBN) was created to address the paucity of help studies in bipolar illness.

Aims

To describe the rationale and methods of the SFBN.

Method

The SFBN includes five core sites and a number of affiliated sites that have adopted consistent methodology for continuous longitudinal monitoring of patients. Open and controlled studies are performed as patients' symptomatology dictates.

Results

The reliability of SFBN raters and the validity of the rating instruments have been established. More than 500 patients are in continuous daily longitudinal follow-up. More than 125 have been randomised to one of three of the newer antidepressants (bupropion, sertraline and venlafaxine) as adjuncts in a study of mood stabilisers and 93 to omega-3 fatty acids. A number of open clinical case series have been published.

Conclusions

Well-characterised patients are followed in a detailed continuous longitudinal fashion in both opportunistic case series and double-blind, randomised controlled trials with reliable and validated measures.

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Copyright
Corresponding author
Dr Robert M. Post, Biological Psychiatry Branch, NIMH Building 10, Room 35239, 10 Center Drive MSC 1272, Bethesda, MD 20892-1272, USA. Tel: +1 301 496 4805
Footnotes
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See Paper 2, pp. s177–s183.

Declaration of interest

Support received from the Theodore and Vada Stanley Foundation.

Footnotes
References
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I. Rationale and methods

  • Robert M. Post (a1), Kirk D. Denicoff (a1), Gabriele S. Leverich (a1), Willem A. Nolen (a2), Ralph W. Kupka (a2), Paul E. Keck (a3), Susan L. McElroy (a3), A. John Rush (a4), Trisha Suppes (a4), Lori L. Altshuler (a5), Mark A. Frye (a5), Heinz Grunze (a6) and Jörg Walden (a7)...
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