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Klinefelter's syndrome (karyotype 47, XXY) and schizophrenia-spectrum pathology

  • Sophie van Rijn (a1), André Aleman (a2), Hanna Swaab (a3) and René S. Kahn (a4)

Summary

Klinefelter's syndrome, characterised by a 47, XXY chromosomal pattern, has largely been associated with physical abnormalities. Here, we report high levels of schizophrenia-spectrum pathology in 32 men with this syndrome in comparison with 26 healthy controls. This may have implications for treatment of Klinefelter's syndrome and suggests that the X chromosome may be involved in the aetiology of schizophrenia.

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Copyright

Corresponding author

Sophie van Rijn, Experimental Psychology, Helmholtz Instituut, Universiteit Utrecht, PO Box 80125, 3508 TC Utrecht, The Netherlands. Tel: +31 30 253 1866; fax: +31 30 253 4511; email: s.vanrijn@fss.uu.nl

References

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Klinefelter's syndrome (karyotype 47, XXY) and schizophrenia-spectrum pathology

  • Sophie van Rijn (a1), André Aleman (a2), Hanna Swaab (a3) and René S. Kahn (a4)
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