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  • Cited by 8
  • Cited by
    Crossref Citations
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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Neugarten, J. Friedman, B. and Golestaneh, L. 2018. Comprehensive Toxicology. p. 304.
    Murck, Harald 2017. Hormones, Brain and Behavior. p. 159.
    Neugarten, J. and Golestaneh, L. 2010. Comprehensive Toxicology. p. 405.
    Xu, Jihong Scholz, Annedore Rösch, Nicole Blume, Annegret Unger, Thomas Kreutz, Reinhold Culman, Juraj and Gohlke, Peter 2005. Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats. Journal of Hypertension, Vol. 23, Issue. 12, p. 2277.
    Lehmann, Karla and Ritz, Eberhard 1995. Angiotensin-converting enzyme inhibitors may cause renal dysfunction in patients on long-term lithium treatment. American Journal of Kidney Diseases, Vol. 25, Issue. 1, p. 82.
    Lang, CC Rahman, AR and Struthers, AD 1991. Lithium does not alter the renal response to a pressor dose of tyramine in man.. British Journal of Clinical Pharmacology, Vol. 31, Issue. 6, p. 705.
    Nagahiro, S. Takada, A. Diksic, M. Sourkes, T. L. Missala, K. and Yamamoto, Y. L. 1990. A New Method to Measure Brain Serotonin Synthesis in vivo. II. A Practical Autoradiographic Method Tested in Normal and Lithium-Treated Rats. Journal of Cerebral Blood Flow & Metabolism, Vol. 10, Issue. 1, p. 13.
    Johnstone, E.C. Owens, D.G.C. Lambert, M.T. Crow, T.J. Frith, C.D. and Done, D.J. 1990. Combination tricyclic antidepressant and lithium maintenance medication in unipolar and bipolar depressed patients. Journal of Affective Disorders, Vol. 20, Issue. 4, p. 225.
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Lithium Carbonate – a Competitive Aldosterone Antagonist?

  • Paul M. Stewart (a1), Sheila M. Atherden (a1), Susan E. Stewart (a1), Lawrence Whalley (a2), Christopher R. W. Edwards (a3) and Paul L. Padfield (a3)...
Abstract

Plasma renin activity (PRA), aldosterone (aldo) levels, electrolyte levels, and blood pressures were measured in 16 patients with affective disorders taking lithium prophylactically, and in 16 age and sex-matched control subjects. PRA and aldo levels were significantly elevated in the lithium-treated group. There was no difference between the groups in plasma electrolytes or erect and supine blood pressures, arguing against secondary aldosteronism. In the lithium-treated group, there was a significant positive correlation between both PRA and plasma aldo vs serum lithium. We postulate that lithium inhibits the action of aldosterone on the distal tubule in the kidney. Activation of the renin angiotensin system maintains normal blood pressure and plasma electrolytes.

Copyright
COPYRIGHT: © Royal College of Psychiatrists, 1988 
Corresponding author
∗ Dr P. M. Stewart, Sir Stanley Davidson Lecturer in Medicine, Department of Medicine, Western General Hospital, Crewe Road South, Edinburgh EH4 2XU
References
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  • Cited by 8
  • Cited by
    Crossref Citations
    Crossref logo
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.
    Neugarten, J. Friedman, B. and Golestaneh, L. 2018. Comprehensive Toxicology. p. 304.
    Murck, Harald 2017. Hormones, Brain and Behavior. p. 159.
    Neugarten, J. and Golestaneh, L. 2010. Comprehensive Toxicology. p. 405.
    Xu, Jihong Scholz, Annedore Rösch, Nicole Blume, Annegret Unger, Thomas Kreutz, Reinhold Culman, Juraj and Gohlke, Peter 2005. Low-dose lithium combined with captopril prevents stroke and improves survival in salt-loaded, stroke-prone spontaneously hypertensive rats. Journal of Hypertension, Vol. 23, Issue. 12, p. 2277.
    Lehmann, Karla and Ritz, Eberhard 1995. Angiotensin-converting enzyme inhibitors may cause renal dysfunction in patients on long-term lithium treatment. American Journal of Kidney Diseases, Vol. 25, Issue. 1, p. 82.
    Lang, CC Rahman, AR and Struthers, AD 1991. Lithium does not alter the renal response to a pressor dose of tyramine in man.. British Journal of Clinical Pharmacology, Vol. 31, Issue. 6, p. 705.
    Nagahiro, S. Takada, A. Diksic, M. Sourkes, T. L. Missala, K. and Yamamoto, Y. L. 1990. A New Method to Measure Brain Serotonin Synthesis in vivo. II. A Practical Autoradiographic Method Tested in Normal and Lithium-Treated Rats. Journal of Cerebral Blood Flow & Metabolism, Vol. 10, Issue. 1, p. 13.
    Johnstone, E.C. Owens, D.G.C. Lambert, M.T. Crow, T.J. Frith, C.D. and Done, D.J. 1990. Combination tricyclic antidepressant and lithium maintenance medication in unipolar and bipolar depressed patients. Journal of Affective Disorders, Vol. 20, Issue. 4, p. 225.
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  • Get access
    Add to cart USD35.00
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Lithium Carbonate – a Competitive Aldosterone Antagonist?

  • Paul M. Stewart (a1), Sheila M. Atherden (a1), Susan E. Stewart (a1), Lawrence Whalley (a2), Christopher R. W. Edwards (a3) and Paul L. Padfield (a3)...
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