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The Long-Term Outcome of Depressive Illness

  • L. G. Kiloh (a1), Gavin Andrews (a2) and Megan Neilson (a2)


One hundred and forty-five patients with primary depressive illness admitted to a university hospital between 1966 and 1970 were followed up an average of 15 years later. Adequate data were obtained on 133 (92%) of the 145. During the follow-up period, 7% of the 133 had suicided, 12% had remained incapacitated by illness and only 20% had remained continuously well. Patients for whom the index admission was not their first were especially likely to be readmitted during the follow-up period. Patients with endogenous depression, none of whom developed schizophrenia during the follow-up period, were more likely to need readmission than patients with an index diagnosis of neurotic depression. In all other respects the prognosis for the two types of depression was the same, with considerable morbidity evident in both.


Corresponding author

Clinical Research Unit for Anxiety Disorders, 299 Forbes Street, Darlinghurst, NSW 2010, Australia


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Andrews, G., Kiloh, L. G. & Neilson, M. (1973) Patterns of depressive illness: the compatibility of disparate points of view. Archives of General Psychiatry, 29, 670673.
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 111, 659674.
Gillespie, R. D. (1929) The clinical differentiation of types of depression. Guy's Hospital Reports, 79.
Kendell, R. E. (1968) The Classification of Depressive Illnesses. London: Oxford University Press.
Kiloh, L. G. & Garside, R. F. (1963) The independence of neurotic depression and endogenous depression. British Journal of Psychiatry, 109, 451463.
Kiloh, L. G., Andrews, G., Bianchi, G. N. & Neilson, M. (1972a) On studying depression. Australian and New Zealand Journal of Psychiatry, 6, 8598.
Kiloh, L. G., Andrews, G., Neilson, M. & Bianchi, G. N. (1972b) The relationship of the syndromes called endogenous and neurotic depression. British Journal of Psychiatry, 121, 183196.
Kiloh, L. G., Andrews, G., & Neilson, M. (1974) The influence of diagnosis on the treatment of depressed patients. In Depression in Everyday Practice (ed. Kielholz, O.). Berne: Hans Huber.
Kiloh, L. G., & Garside, R. F. (1977) Depression: a multivariate study of Sir Aubrey Lewis's data on melancholia. Australian and New Zealand Journal of Psychiatry, 11, 149156.
Kraepelin, E. (1913) Psychiatrie Vol. 3, 8th edn Leipzig.
Lee, A. S. & Murray, R. M. (1988) The long term outcome of Maudsley depressives. British Journal of Psychiatry, 153, 741751
Lewis, A. J. (1934a) Melancholia: a historical review. Journal of Mental Science, 80, 142.
Lewis, A. J. (1934b) Melancholia: a clinical survey of depressive states. Journal of Mental Science, 80, 277378.
Lewis, A. J. (1936) Melancholia: prognostic studies and case material. Journal of Mental Science, 82, 488558.
Lewis, A. J. (1938) States of depression: their clinical and aetiological differentiation. British Medical Journal, ii, 875878.
Mapother, E. (1926) Discussion on manic-depressive psychosis. British Medical Journal, ii, 872879.
Mapother, E. & Lewis, A. J. (1937). Psychological medicine. In A Textbook of the Practice of Medicine (5th edn)(ed. Price, F. W.). London: Oxford University Press.
Quality Assurance Project (1983) A treatment outline for depressive disorders. Australian and New Zealand Journal of Psychiatry, 17, 129146.
Vaillant, G. E. & Schnurr, P. (1988) A forty-five year study of psychiatric impairment within a college sample selected for mental health. Archives of General Psychiatry, 45, 313319.
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  • EISSN: 1472-1465
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The Long-Term Outcome of Depressive Illness

  • L. G. Kiloh (a1), Gavin Andrews (a2) and Megan Neilson (a2)
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